Mouse Strain: BX129-Neurod1tmAK71(lacZ)Jle/Mmcd
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MMRRC (Stock # 000367-UCD)
MMRRC (Stock # 000367-UCD)
| Mouse Information | |
|---|---|
| Official Name of Strain/Stock: | BX129-Neurod1tmAK71(lacZ)Jle/Mmcd |
| Common Name of Strain/Stock: | NeuroD/lacZ Knock-In |
| Description: | Homozygous phenotype: Postnatal lethal due to neonatal diabetes Pancreas--5% insulin production, no islet formation Gut--no CCK or secretin production Inner ear defects resulting in deafness--no cochlear ganglia and poor vestibular ganglia formation Cerebellar defect resulting in ataxia-- >90% depletion of cerebellar granule cells Hippocampal defects--no dentate gyrus. |
| Categories: | None specified |
| Genetic Alteration Information | ||
|---|---|---|
| 1) BAC or Transgene Insertion | ||
| Type of Vector: | Plasmid |
|
| Promoter: |
neurogenic differentiation 1 (Neurod1 - MGI:1339708 ) |
|
| Expressed Gene: |
LacZ-Neo (LacZ-Neo) |
|
| Description of Transgene: | Not Provided |
|
| Insertion Site : |
Not Provided |
|
| Vector Genbank File: | Unavailable |
|
| Citations: | 10398678 |
|
| Strain Information | ||
| Strain Type: | Recombinant Inbred |
|
| Chimera/Founder Genetic BG: |
129/SvJ |
|
| Current Genetic BG: |
C57BL/6J |
|
| # Gen. Backcrossed: | Not Provided |
|
| Strain Description: | None provided. |
|
| Contact Information | ||
| Donating Investigator: | Jackie Lee, University of Colorado, Boulder | |
| Preferred Contact: | Investigator | |
| Name: | Jackie Lee | |
| Institution: | University of Colorado, Boulder | |
| Phone: | 303.492.6703 | |
| Email: |
|
|
| Holding Sites | ||
| 1) | Type: | Repository |
| Name: | MMRRC - Mutant Mouse Regional Resource Centers | |
| Stock#: | 000367-UCD | |
| State: | Cryopreserved embryos, Cryopreserved or freeze-dried sperm | |
