Fat and Normal adipocytes from insulin receptor knockout mice sorted into small and large cells - Study GBCO2333

Genomics Study Specifications

Study Name

Fat and Normal adipocytes from insulin receptor knockout mice sorted into small and large cells

Contact Name

Ronald C Kahn (Joslin Diabetes Center and Harvard Medical School)

Publication

http://www.ncbi.nlm.nih.gov/pubmed/15131119

My Strategies

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Classification

Cell stimulation/injury

Links

Biomaterials Graph

ArrayExpress

BCBC Release Date

April 13, 2009

Public Release Date

April 13, 2009

Citation

Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem. 2004. 279:31891-901

Synopsis

Study Description
Goals
Approaches
Results
Conclusions
Related Studies

Mice with fat-specific disruption of the insulin receptor gene (FIRKO mice) have low fat mass, and are protected against obesity and obesity-related glucose intolerance. FIRKO mice also exhibit polarization of adipocytes into populations of large and small cells. Other PubMed identifiers for this study: 15131120,12110165,15131119

No goal information provided

No approach information provided

No result information provided

No conclusion information provided

No studies listed

Platform types

Expression microarray, Expression

Platforms

Show platform Affymetrix MG_U74A

Study Design Type

cell_type_comparison_design
genetic_modification_design

Study Factors

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Study Assays

Show study assays

ID	Assay name	Study factor name	Study factor value
8887	m_iso-W-adip-large_FIRKO_1	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8887	m_iso-W-adip-large_FIRKO_1	Adipocyte Cell Type	Large Adipocyte
8888	m_iso-W-adip-large_FIRKO_2	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8888	m_iso-W-adip-large_FIRKO_2	Adipocyte Cell Type	Large Adipocyte
8889	m_iso-W-adip-large_FIRKO_3	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8889	m_iso-W-adip-large_FIRKO_3	Adipocyte Cell Type	Large Adipocyte
8890	m_iso-W-adip-large_FIRKO_4	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8890	m_iso-W-adip-large_FIRKO_4	Adipocyte Cell Type	Large Adipocyte
8891	m_iso-W-adip-large_FIRKO_5	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8891	m_iso-W-adip-large_FIRKO_5	Adipocyte Cell Type	Large Adipocyte
8892	m_iso-W-adip-large_IRlox_1	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8892	m_iso-W-adip-large_IRlox_1	Adipocyte Cell Type	Large Adipocyte
8893	m_iso-W-adip-large_IRlox_2	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8893	m_iso-W-adip-large_IRlox_2	Adipocyte Cell Type	Large Adipocyte
8894	m_iso-W-adip-large_IRlox_3	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8894	m_iso-W-adip-large_IRlox_3	Adipocyte Cell Type	Large Adipocyte
8895	m_iso-W-adip-large_IRlox_4	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8895	m_iso-W-adip-large_IRlox_4	Adipocyte Cell Type	Large Adipocyte
8896	m_iso-W-adip-small_FIRKO_1	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8896	m_iso-W-adip-small_FIRKO_1	Adipocyte Cell Type	Small Adipocyte
8897	m_iso-W-adip-small_FIRKO_2	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8897	m_iso-W-adip-small_FIRKO_2	Adipocyte Cell Type	Small Adipocyte
8898	m_iso-W-adip-small_FIRKO_3	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8898	m_iso-W-adip-small_FIRKO_3	Adipocyte Cell Type	Small Adipocyte
8899	m_iso-W-adip-small_FIRKO_4	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8899	m_iso-W-adip-small_FIRKO_4	Adipocyte Cell Type	Small Adipocyte
8900	m_iso-W-adip-small_FIRKO_5	Insulin Receptor Knock-Out vs. Control	(Fat) Insulin Receptor Knock out
8900	m_iso-W-adip-small_FIRKO_5	Adipocyte Cell Type	Small Adipocyte
8901	m_iso-W-adip-small_IRlox_1	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8901	m_iso-W-adip-small_IRlox_1	Adipocyte Cell Type	Small Adipocyte
8902	m_iso-W-adip-small_IRlox_2	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8902	m_iso-W-adip-small_IRlox_2	Adipocyte Cell Type	Small Adipocyte
8903	m_iso-W-adip-small_IRlox_3	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8903	m_iso-W-adip-small_IRlox_3	Adipocyte Cell Type	Small Adipocyte
8904	m_iso-W-adip-small_IRlox_4	Insulin Receptor Knock-Out vs. Control	IR (lox/lox)
8904	m_iso-W-adip-small_IRlox_4	Adipocyte Cell Type	Small Adipocyte