Mouse Information
| Common Name: |
Pdx1deltaI-II-III |
| MGI Official Name: |
Pdx1tm3Cvw |
| Description: |
Area I-II-III, a conserved 5' cis-regulatory region of Pdx1, was removd by Cre mediated recombination in the germline of Pdx1tm5Cvw (Pdx1Flox123) by crossing to deleter Cre mice. This allele was shown to be a hypomorph. |
| Categories: |
None specified.
|
Genetic Alterations
| 1) Targeted Mutagenesis |
|---|
| Type of Allele |
Global Mutation
|
| Targeted Gene |
Pancreatic and Duodenal homeobox 1
(Pdx1 - NCBI GeneID:18609)
|
| Targeted Allele |
targeted mutation 3
(Pdx1{tm3(deltaI-II-III) - MGI:3702893)
|
| Description of Targeting Vector |
Not provided
|
| Targeting Vector Genbank File |
Not provided
|
| Citations |
| PubMedID |
Citation |
| 16418487 |
Targeted deletion of a cis-regulatory region reveals differential gene
dosage requirements for Pdx1 in foregut organ differentiation and pancreas
formation. (2006) Genes Dev 20: 253-66
(Added 2008-03-29 17:06:49) |
|
Strain Information
| Strain Type: |
Mixed |
| Chimera/Founder Genetic Background: |
129S6/SvEvTac |
| Current Genetic Background: |
129BL6/DAB2 Mix (date recorded: Not provided)
|
| Strain Description: |
Not provided |
Associated Images
|
No associated images have been supplied
|
Repositories
Contact Information
Associated Publications
No publications associated
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