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Dll1flox - Mouse Strain RES246


Mouse Information

Common Name: Dll1flox
MGI Official Name: Dll1tm1Hri
Description: Targeted mutation of the Notch ligand Dll1, introducing two loxP sites flanking the exons encoding the DSL domain.
Categories: Cre-lox floxed alleles


Genetic Alterations

1) Targeted Mutagenesis
Type of Allele Conditional Null
Targeted Gene Delta-like 1   (Dll1 - NCBI GeneID:13388)
Targeted Allele targeted mutation 1 (Dll1tm1Hri - MGI:104659)
Description of Targeting Vector

Introduces: 1) two loxP sites flanking the exons encoding the DSL domain, and 2) a neo cassette flanked by Flp sites.
Targeting Vector Genbank File Not provided
Citations Not Available


Strain Information

Strain Type: Inbred Strain
Chimera/Founder Genetic Background: 129
Current Genetic Background: C57BL/6 (date recorded: Not provided)
Strain Description: Originally on a mixed 129 x B6 background and now back crossed to B6 for 6 generations


Associated Images

No associated images have been supplied

Repositories

Serup Lab
No URL supplied for repository Stock #: VUMC-DF
Availability Notes: Not provided

Contact Information

Preferred Contact
Name
Institution Not provided
Phone Not provided
Email
Primary Lab Contact
Name Not provided
Institution Not provided
Phone Not provided
Email Not provided

Associated Publications

Publication Citation
22529374 Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN Mind bomb 1 is required for pancreatic β-cell formation. (2012) Proc Natl Acad Sci U S A 109: 7356-61 (Added January 31, 2013)

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Primary contributor: Palle Serup
Co-contributed by:

Resource Tags

Dll1, Dll1flox, mESC Core, mouse, mouse strain
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Resource History & Actions

Approved on Aug 21, 2008
Last modified on Aug 21, 2008
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