Nkx2.2:NK2domain mutation - Mouse Strain RES241

Mouse Information

Common Name:	Nkx2.2:NK2domain mutation
MGI Official Name:	Nkx2-2^tm4Suss
Description:	The strain carries a mutant Nkx2.2 allele in which conserved residues of the NK2 domain are mutated to alanines.
Categories:	None specified.

1) RMCE Targeted Mutagenesis
Type of Allele	Global Mutation
Targeted Gene	Nkx2.2 (Nkx2.2 - NCBI GeneID:18088)
Targeted Allele	Nkx2.2-NK2 mutation (Nkx2.2(NK2mut))
Description of Targeting Vector	The vector contains amino acid substitutions in the NK2 domain. The rest of the Nkx2.2 protein is intact and wildtype.
Targeting Vector Genbank File	production_of_exchange_vector.doc
Recombinase-Mediated Cassette Exchange Stage
Type of Allele:	Not available
Exchanged Cassette Gene	Not provided.
Exchanged Cassette Allele Name
Description of Exchange Vector	Not provided
Exchange Vector Genbank File:	Not Available
Citations	Not Available

Strain Type:	Mixed
Chimera/Founder Genetic Background:	129S6/SvEvTac
Current Genetic Background:	Mixed (date recorded: Not provided)
Strain Description:	The strain was created on a 129 background. Once the strain is transferred to the Sussel lab, it will be maintained on a Swiss Black background.

Image 1
	Description: Conserved amino acid sequence in the NK2 domain of all mouse Nkx2 family members and alanine substitutions present in the mutant allele. Reference: Not provided

Sussel Lab
Request this resource	Stock #: VUMC-KJ Availability Notes: Not provided

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Primary contributor: Sussel Lab
Co-contributed by:

mESC Core, mouse, mouse strain, Nkx2.2, Nkx2.2:NK2domain mutation, RMCE

Approved on Aug 08, 2008
Last modified on Aug 11, 2008

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