Nkx2.2:LacZ - Mouse Strain RES240

Mouse Information

Common Name:	Nkx2.2:LacZ
MGI Official Name:	Nkx2-2^tm1Suss
Description:	The lacZ gene has been knocked in to the Nkx2.2 genomic locus using RMCE, effectively replacing the two coding exons.
Categories:	LacZ

1) RMCE Targeted Mutagenesis
Type of Allele	Gene Replacement
Targeted Gene	Nkx2.2 (Nkx2.2 - NCBI GeneID:18088)
Targeted Allele	Nkx2.2:LacZ (Nkx2.2:LacZ)
Description of Targeting Vector	LacZ is knocked into the Nkx2.2 genomic locus using the Nkx2.2 endogenous ATG and deleting exon 1 and exon 2 (including intervening intron) of Nkx2.2.
Targeting Vector Genbank File	production_of_exchange_vector.doc
Recombinase-Mediated Cassette Exchange Stage
Type of Allele:	Not available
Exchanged Cassette Gene	Not provided.
Exchanged Cassette Allele Name
Description of Exchange Vector	Not provided
Exchange Vector Genbank File:	Not Available
Citations	Not Available

Strain Type:	Mixed
Chimera/Founder Genetic Background:	129S6/SvEvTac
Current Genetic Background:	Mixed (date recorded: Not provided)
Strain Description:	The strain was generated on a 129 background. Once it arrives to the Sussel lab, it will be maintained on an Swiss Black outbred background.

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Sussel Lab
Request this resource	Stock #: Not provided Availability Notes: Not provided

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Primary contributor: Sussel Lab
Co-contributed by:

LacZ, mESC Core, mouse, mouse strain, Nkx2.2, Nkx2.2:LacZ, RMCE

Approved on Jul 29, 2008
Last modified on Jan 07, 2010

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