Myt1Flox - Mouse Strain RES229
Mouse Information
| Common Name: | Myt1Flox |
|---|---|
| MGI Official Name: | Myt1tm1.1Ggu |
| Description: | Two loxP sites flank exon 6 of Myt1b. The allele behaves as wild type allele without Cre-mediated deletion. Cre-mediated deletion creates null Myt1 allele. The homozygous null is neonatal lethal. Myt1 null pancreas has abnormal islet cell differentiation, i.e. single cells produce multiple hormones. Pancreatic-specific Myt1 deletion results in glucose intolerance in males. |
| Categories: |
Cre-lox floxed alleles |
Genetic Alterations
| 1) Targeted Mutagenesis | |||||
|---|---|---|---|---|---|
| Type of Allele | Conditional Null | ||||
| Targeted Gene | Myt1 (myelin transcriptioin factor 1) (Myt1 - NCBI GeneID:1100535 ) | ||||
| Targeted Allele |
targeted mutation 1.1
(Myt1tm1.1Ggu - MGI:3765056)
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| Description of Targeting Vector | The gene target contains DTA as a negative selection marker and FRT-flanked pGK-neo as a positive selection marker. The target has an 8.2 kb 5' arm and a 4 kb 3' arm. The floxed region is 1 kb.
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| Targeting Vector Genbank File |
pMyt1.TV_constructed.gb |
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| Citations |
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Strain Information
| Strain Type: | Mixed |
|---|---|
| Chimera/Founder Genetic Background: | 129S6/SvEvTac |
| Current Genetic Background: | CD1 (date recorded: Not provided) |
| Strain Description: | Not provided |
Associated Images
| Image 1 | |
|---|---|
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Description: Exon 3 of the Myt1 gene was floxed. This creates a nonsense mutation in the Myt1 gene and is expected to produce a null allele. Reference: Not provided |
Repositories
| MMRRC | |
|---|---|
 Request via www.mmrrc.org website
|
Stock #: 030295-UNC Availability Notes: Not provided |
Contact Information
| Preferred Contact | |
|---|---|
| Name | Guoqiang Gu |
| Institution | Vanderbilt University |
| Phone | 615-936-3634 |
| guoqiang.gu@vanderbilt.edu | |
| Primary Lab Contact | |
| Name | Guoqiang Gu |
| Institution | Vanderbilt University |
| Phone | 615-936-3634 |
| guoqiang.gu@vanderbilt.edu | |
Associated Publications
No publications associated
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