Arx knockout mice - Mouse Strain RES225

Mouse Information

Common Name:	Arx knockout mice
MGI Official Name:	Arx^tm1Pgr
Description:	These mice were created by insertion of the LacZ gene (with nuclear localization signal) into the Arx locus by homologous recombination in embryonic stem cells. The Arx gene is localized on the X chromosome. Knockout mice die after birth with due to hypoglycemia. Therefore male mice die at day 2 past birth. The colony has to be propagated with female mice. Arx-deficient mice do not produce alpha cells in the islets of Langerhans.
Categories:	LacZ

1) Targeted Mutagenesis

Type of Allele

Gene Replacement

Targeted Gene

Arx (Arx - NCBI GeneID:11878)

Targeted Allele

targeted mutation 1 (Arx^tm1Pgr - MGI:2679972)

Description of Targeting Vector

The first two exons were replaced by a cassette consisting of NLSLacZ and PGKneo (flanked by LoxP sites. Total homology length is 10.5 kb

Targeting Vector Genbank File

Not provided

Citations

PubMedID	Citation
14561778	Opposing actions of Arx and Pax4 in endocrine pancreas development. (2003) Genes Dev 17: 2591-603 (Added 2005-06-21 07:27:21)

Strain Type:	Inbred Strain
Chimera/Founder Genetic Background:	129
Current Genetic Background:	129 Sv (date recorded: Not provided)
Strain Description:	more than 10 generations backcross to 129 Sv

No associated images have been supplied

MMRRC
Request via www.mmrrc.org website	Stock #: Not provided Availability Notes: Not provided

No publications associated

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Primary contributor: Ahmed Mansouri

Arx knockout mice, mouse, mouse strain

Approved on Feb 25, 2008
Last modified on Oct 30, 2009

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