not available - Mouse Strain RES214
Mouse Information
| Common Name: | not available |
|---|---|
| MGI Official Name: | NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(Ins1-EGFP/GH1)14Hara/Sz |
| Description: | NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(Ins1-EGFP/GH1)14Hara/Sz is a immunodeficient mouse carries a GFP transgene under the control of mouse insulin promoter 1, which leads to expression of eGFP in the beta cells. |
| Categories: |
HUMANE |
Genetic Alterations
| 1) Targeted Mutagenesis | |||||
|---|---|---|---|---|---|
| Type of Allele | Global Null | ||||
| Targeted Gene | interleukin 2 receptor, gamma chain (Il2rg - NCBI GeneID:16186) | ||||
| Targeted Allele |
targeted mutation 1
(Il2rgtm1Wjl - MGI:1857455)
|
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| Description of Targeting Vector | Not provided |
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| Targeting Vector Genbank File | Not provided | ||||
| Citations |
|
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| 3) BAC or Transgene Insertion | |||||
| Type of Vector | Not provided |
||||
| Promoter |
Mouse insulin I
(MIP - MGI:16333)
|
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| Expressed Gene | human growth hormone I (HGH - MGI:2688) | ||||
| Description of Transgene | This transgenic allele expresses Enhanced Green Fluorescent Protein fused to a 2.1kb fragment of human Growth Hormone under the control of Mouse Insulin Promoter 1. The transgenic construct was injected directly into NOD/LtJ oocytes. The transgene comprises a DNA fragment containing the mouse insulin 1 promoter, extending from 8.5 kb upstream of the transcription initiation site to nucleotide +12, driving expression of a fusion gene joining the 7.6-kb coding region of the enhanced green fluorescent protein (EGFP) gene to a 2.1-kb fragment of the human growth hormone 1 gene that confers high-level expression. |
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| Vector Genbank File | Not provided | ||||
| Citations | Not provided | ||||
Strain Information
| Strain Type: | Congenic Strain |
|---|---|
| Chimera/Founder Genetic Background: | Not provided |
| Current Genetic Background: | Not provided (date recorded: Not provided) |
| Strain Description: | Not provided |
Associated Images
| No associated images have been supplied | |
Repositories
| Herrera Lab | |
|---|---|
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|
Stock #: Not provided Availability Notes: Not provided |
Contact Information
| Not provided |
Associated Publications
No publications associated
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