not available - Mouse Strain RES212
Mouse Information
| Common Name: | not available |
|---|---|
| MGI Official Name: | NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/Sz |
| Description: | Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg null mice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rg null mice. |
| Categories: |
HUMANE |
Genetic Alterations
| 1) Targeted Mutagenesis | |||||
|---|---|---|---|---|---|
| Type of Allele | Global Null | ||||
| Targeted Gene | recombination activating gene 1 (Rag1 - NCBI GeneID:19373) | ||||
| Targeted Allele |
Not provided
(Rag1tm1Mom - MGI:1857241)
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| Description of Targeting Vector | Not provided |
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| Targeting Vector Genbank File | Not provided | ||||
| Citations |
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| 2) Targeted Mutagenesis | |||||
| Type of Allele | Global Null | ||||
| Targeted Gene | interleukin 2 receptor, gamma chain (Il2rg - NCBI GeneID:16186) | ||||
| Targeted Allele |
Not provided
(Il2rgtm1Wjl - MGI:1857455)
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| Description of Targeting Vector | Not provided |
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| Targeting Vector Genbank File | Not provided | ||||
| Citations |
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Strain Information
| Strain Type: | Congenic Strain |
|---|---|
| Chimera/Founder Genetic Background: | Not provided |
| Current Genetic Background: | Not provided (date recorded: Not provided) |
| Strain Description: | Not provided |
Associated Images
| Image 1 | |
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Description: Cohorts of NOD-rag1nullIL2rgnull mice were treated with varying doses of whole body irradiation and their survival determined. (survival) Reference: PMID:18785974 |
| Image 2 | |
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Description: Human RBMC engraftment. Three indicated stocks of immunodeficient mice were injected intravenously with 20x106 human peripheral blooc mononuclear cells (PBMC) ans assessed for human cell engraftment in the blood four weeks lager. symbols represent induividual animals. Bars represent the mean percentage engraftment Reference: PMID:18785974 |
Repositories
| Herrera Lab | |
|---|---|
 Request this resource
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Stock #: Not provided Availability Notes: Not provided |
Contact Information
| Not provided |
Associated Publications
No publications associated
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