Autosomal beta-cell toxigene strain - Mouse Strain RES209
Mouse Information
| Common Name: | Autosomal beta-cell toxigene strain |
|---|---|
| MGI Official Name: | NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(Ins2-HBEGF)6832Ugfm/Sz |
| Description: | NOD-Prkdcscid IL2rg null Tg(Ins2- HBEGF)6832Ugfm mice are deficient in mature lymphocytes and NK cells, survive beyond 16 months of age, and even after sublethal irradiation resist lymphoma development. They can be induced to become hypoglycemic when Diphtheria toxin is used. 100% of beta cells will be depleted upon administration of diphtheria toxin. |
| Categories: |
HUMANE |
Genetic Alterations
| 1) BAC or Transgene Insertion | |||||
|---|---|---|---|---|---|
| Type of Vector | Plasmid |
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| Promote: |
Rat insulin II
(RIP)
|
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| Expressed Gene | Diphtheria toxin receptor (DTR) | ||||
| Description of Transgene | The RIP-DTR transgene was made by Pedro Herrera by subcloning the human HB-EGF cDNA into the EcoRI/SaII sites of a plasmid containing a 0.7Kb-long fragment of the rat insulin II promoter, and a 1.6 kb-long sequence containing an intron and the polyA signal of the rabbit beta globin gene. |
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| Vector Genbank File | Not provided | ||||
| Citations | Not provided | ||||
| 2) Targeted Mutagenesis | |||||
| Type of Allele | Global Null | ||||
| Targeted Gene | interleukin 2 receptor, gamma chain (Il2rg - NCBI GeneID:16186) | ||||
| Targeted Allele |
Not provided
(Il2rgtm1Wjl - MGI:96551)
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| Description of Targeting Vector | Not provided |
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| Targeting Vector Genbank File | Not provided | ||||
| Citations |
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Strain Information
| Strain Type: | Congenic Strain |
|---|---|
| Chimera/Founder Genetic Background: | Not provided |
| Current Genetic Background: | Not provided |
| Strain Description: | Not provided |
Associated Images
| No associated images have been supplied | |
Repositories
| Herrera Lab | |
|---|---|
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|
Stock #: Not provided Availability Notes: Not provided |
Contact Information
| Not provided |
Associated Publications
No publications associated
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