Mouse Information
| Common Name: |
Pdx1-Ngn3-ER |
| MGI Official Name: |
Tg(Pdx1-Neurog3-ER)1Agb |
| Description: |
The transgene is driven by the Pdx1 promoter whcih targets it in pancreas progenitor during development. These mice express a fusion protein between the pro-endocrine transcription factor Ngn3 and the tamoxifen responsive estrogen receptor. An IRES site allows GFP to be co-expressed with Ngn3-ER. The protein is active only upon tamoxifen injection. |
| Categories: |
Fluorescent Probes
|
Genetic Alterations
| 1) BAC or Transgene Insertion |
|---|
| Type of Vector |
Plasmid
|
| Promoter |
Pancreatic and duodenal homeobox 1
(Pdx1 - MGI:18609)
|
| Expressed Gene |
Neurogenin3-Tamoxifen responsive estrogen receptor fusion
(Neurog3-ER - MGI:11925)
|
| Description of Transgene |
Tamoxifen-inducible Ngn3 under control of Ipf1 promoter
|
| Vector Genbank File |
Not provided |
| Citations |
| PubMedID |
Citation |
| 17336910 |
Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. (2007) Dev Cell 12: 457-65
(Added 2007-03-27 01:47:29) |
|
Strain Information
| Strain Type: |
Mixed |
| Chimera/Founder Genetic Background: |
B6D2F1 |
| Current Genetic Background: |
CD1 (date recorded: Not provided)
|
| Strain Description: |
Transgenic line was made by pronuclear injection into B6/D2 F1 hybrid fertilized oocytes and has since been bred to CD1 outbred mice. |
Associated Images
|
No associated images have been supplied
|
Repositories
Contact Information
| Preferred Contact |
| Name |
Not provided |
| Institution |
Not provided |
| Phone |
Not provided |
| Email |
Not provided |
Associated Publications
No publications associated
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