Mouse Information
| Common Name: |
NeuroD/lacZ Knock-In |
| MGI Official Name: |
BX129-Neurod1tmAK71(lacZ)Jle/Mmcd |
| Description: |
Homozygous phenotype: Postnatal lethal due to neonatal diabetes Pancreas--5% insulin production, no islet formation Gut--no CCK or secretin production Inner ear defects resulting in deafness--no cochlear ganglia and poor vestibular ganglia formation Cerebellar defect resulting in ataxia-- >90% depletion of cerebellar granule cells Hippocampal defects--no dentate gyrus. |
| Categories: |
None specified.
|
Genetic Alterations
| 1) BAC or Transgene Insertion |
|---|
| Type of Vector |
Plasmid
|
| Promoter |
neurogenic differentiation 1
(Neurod1 - MGI:18012)
|
| Expressed Gene |
LacZ-Neo
(LacZ-Neo)
|
| Description of Transgene |
Not provided
|
| Vector Genbank File |
Not provided |
| Citations |
| PubMedID |
Citation |
| 10398678 |
NeuroD is required for differentiation of the granule cells in the
cerebellum and hippocampus. (1999) Genes Dev 13: 1647-52
(Added 2006-11-13 07:21:38) |
|
Strain Information
| Strain Type: |
Recombinant Inbred |
| Chimera/Founder Genetic Background: |
129/SvJ |
| Current Genetic Background: |
C57BL/6J (date recorded: Not provided)
|
| Strain Description: |
None provided. |
Associated Images
|
No associated images have been supplied
|
Repositories
Contact Information
| Preferred Contact |
| Name |
Jackie Lee |
| Institution |
University of Colorado, Boulder |
| Phone |
303.492.6703 |
| Email |
jackie.lee@colorado.edu |
| Primary Lab Contact |
| Name |
Not provided |
| Institution |
Not provided |
| Phone |
Not provided |
| Email |
Not provided |
Associated Publications
No publications associated
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