ngn3-EGFP - Mouse Strain RES176

Mouse Information

Common Name:	ngn3-EGFP
MGI Official Name:	B6.129S-Neurog3^tm1(EGFP)Khk/Mmcd
Description:	A targeted mutation at the Neurogenin 3 locus where EGFP replaces entire coding region of Neurogenin3. The basic phenotype is EGFP expression in developing endocrine cells of pancreas and in glandular regions of the stomach.
Categories:	Fluorescent Probes

1) Targeted Mutagenesis

Type of Allele

Gene Replacement

Targeted Gene

Neurogenin 3 (Neurog3 - NCBI GeneID:11925)

Targeted Allele

targeted mutation 1, Klaus H Kaestner ( Neurog3^tm1(EGFP)Khk - MGI:2651394)

Description of Targeting Vector

Not provided

Targeting Vector Genbank File

Not provided

Citations

PubMedID	Citation
12080087	Neurogenin 3 is essential for the proper specification of gastric (2002) Genes Dev 16: 1488-97 (Added 2005-04-13 12:55:28)

Strain Type:	Congenic Strain
Chimera/Founder Genetic Background:	129
Current Genetic Background:	C57BL/6 (date recorded: Not provided)
Strain Description:	Not provided

Image 1
	Description: Targeting strategy for ngn3 inactivation. (A) Gene structure of the ngn3 locus (top). Targeting vector used for homologous recombination in ES cells (middle). Gene structure of the targeted allele (bottom). Not all of the restriction enzymes are depicted in the diagram. Reference: 12080087

MMRRC
Request via www.mmrrc.org website	Stock #: 000344-UCD Availability Notes: Not provided

No publications associated

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Primary contributor: Kaestner Lab

EGFP, mouse, mouse strain, Ngn3, ngn3-EGFP

Approved on Mar 07, 2006
Last modified on Jul 11, 2007

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