NOD-scidIL2gnull - Mouse Strain RES1262
Mouse Information
| Common Name: | NOD-scidIL2gnull |
|---|---|
| MGI Official Name: | NOD.Cg-PrkdcscidIl2rgtm1Wjl/Sz |
| Description: | NOD-scid IL2rgnull mice are deficient in mature lymphocytes and NK cells, survive beyond 16-month of age, and even after sublethal irradiation resist lymphoma development. Moreover, cytokine-mobilized human peripheral blood stem cells engraft at high levels in NOD-scid IL2rgnull mice and develop into human CD3+CD4+ and CD3+CD8+ T cells, Ig+B cells, myeloid cells, NK cells and plasmacytoid dentritic cells. |
| Categories: |
HUMANE |
Genetic Alterations
| 2) Targeted Mutagenesis | |||||
|---|---|---|---|---|---|
| Type of Allele | Global Null | ||||
| Targeted Gene | interleukin 2 receptor, gamma chain (Il2rg - NCBI GeneID:16186) | ||||
| Targeted Allele |
targeted mutation 1
(Il2rgtm1Wjl - MGI:96551)
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| Description of Targeting Vector | Not provided |
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| Targeting Vector Genbank File | Not provided | ||||
| Citations |
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Strain Information
| Strain Type: | Not provided |
|---|---|
| Chimera/Founder Genetic Background: | Not provided |
| Current Genetic Background: | Not provided (date recorded: Not provided) |
| Strain Description: | Not provided |
Associated Images
| Image 1 | |
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Description: Induction of diabetes in NOD-scid IL2rgnull mice. HOhorts of male (black circles) and female (white circles) NOD-scid IL2rgnull mice were randomised to receive a single i.p. injection of streptozotocin at doses of 145, 150, 155 or 160 mg/kg body weight and teh results are stratified into lower dose (145 and 150 mg/kg) and higher dose (155 and 160 mg/kg). Mazimum blood glucose readings for each recipient at up to 10 days after injection are shown. Horizontal bar, mean value. (hyperglycemia) Reference: PMID:18563383 Peason et al. (2008) Diabetologia 51:1449-1456; Fig. 3 with kind permission of Springer Science and Business Media |
| Image 2 | |
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Description: Cumulative percent survival of NOD-scid IL2rgnull and NOD-scid mice as a funciton of age. Data are based on 34 NOD-scid IL2rfnull and 35 NOD-scid mice observed form birth. (survival) Reference: PMID:15879151 Shultz. et al (2005) J. Immunol. 174, 6477-6489 Copyright 2005 The American Association of Immunologists, Inc. |
| Image 3 | |
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Description: Reversal of diabetes in NOD-scid IL2rgnull mice follwoing human islet tansplantation. Mice were rendered hyperglycemic by a single i.p. injection of 140 mg/kg STZ, randomised into four different groups and received either 1,000 (a, n=6), 2,000 (b, n=10), 3,000 (c, n=11), or 4,000 (d, n=4) IEQ of human islets into the renal subcapsular space. Blood glucose levels in individual mice at each human islet dose are shown over the follow-up period. (islet transplantation) Reference: PMID:18563383 Peason et al. (2008) Diabetologia 51:1449-1456; Fig.5 with kind permission of Springer Science and Business Media
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| Image 4 | |
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Description: Human RBMC engraftment. Three indicated stocks of immunodeficient mice were injected intravenously with 20x106 human peripheral blooc mononuclear cells (PBMC) ans assessed for human cell engraftment in the blood four weeks lager. symbols represent induividual animals. Bars represent the mean percentage engraftment Reference: PMID:18785974 |
Repositories
| Shultz Lab | |
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 Request this resource
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Stock #: Not provided Availability Notes: Not provided |
Contact Information
| Preferred Contact | |
|---|---|
| Name | Leonard Shultz |
| Institution | The Jackson Laboratory |
| Phone | 207-288-6405 |
| lenny.shultz@jax.org | |
| Primary Lab Contact | |
| Name | Leonard Shultz |
| Institution | The Jackson Laboratory |
| Phone | 207-288-6405 |
| lenny.shultz@jax.org | |
Associated Publications
No publications associated
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