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Cyclophosphamide-induced beta Cell Destruction in NOD Mice - Study GBCO2000

Genomics Study Specifications

Study Name Cyclophosphamide-induced beta Cell Destruction in NOD Mice
Contact Name Christophe Benoist (Joslin Diabetes Center and Harvard Medical School)
Publication http://www.ncbi.nlm.nih.gov/pubmed/15331540
My Strategies Return to My Strategies page
Classification Islet/beta-cell stimulation/injury; Cell stimulation/injury
BCBC Release Date October 19, 2005
Public Release Date October 19, 2005
Citation Matos M, Park R, Mathis D, Benoist C. Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview. Diabetes. 2004. 53:2310-21
Type 1 diabetes appears to progress in a highly regulated manner and insulitis can persist for long periods of time before the terminal destruction of beta cells. To study the final stage of diabetogenesis, BDC2.5/NOD mice were treated with cyclophosphamide to induce type 1 diabetes. Pancreatic islets were analyzed using the Affymetrix MU74v2A microarray platform before treatment (Eight Samples at Day 0) and as treatment progressed (Four Samples at Day 1, Three Samples at Day 2, and Three Samples at Day 3).
No goal information provided
No approach information provided
No result information provided
No conclusion information provided
Platform types Expression microarray, Expression
Platforms Show platform Affymetrix MG_U74A
Study Design Type
  • compound_treatment_design
  • time_series_design
Study Factors Show study factors
Study Assays Show study assays

Access to Study Data

This Study Data is publicly available to all users.

Gene List(s)



Stoeckert Lab
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Approved on Oct 19, 2005
Last modified on Jan 17, 2012
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