TRAFEX - TRAnscription Factor EXpression survey
A description, tutorial and FAQ will soon be available.
Click here for a sample search for PTF1A, IPF1, NeuroD1 and Neurog3
TRAFEX is a searchable database of gene expression data. To begin using TRAFEX, scroll down to the the three search options: Predefined Search, Simple Search, and Complex Search. All settings are saved as you navigate from one search option to another.
A global survey of RNA from 14 fetal and 12 adult human organs by RT-PCR determined the expression patterns of 790 genes encoding DNA-binding transcription factors. The data can be searched and sorted to identify sets of transcription factors with expression restricted to a given organ or to particular organ groups. These data are a resource to help define the spectrum of transcription factor control, contribute to the elucidation of transcription factor cascades responsible for the development and maintenance of each organ, and provide a baseline to study the effects of disease or developmental defects.
Contributed by Dr. Ray MacDonald,
as published: Kong YM, MacDonald RJ, Wen X, Yang P, Barbera VM, Swift GH.
A comprehensive survey of DNA-binding transcription factor gene expression
in human fetal and adult organs. Gene Expr Patterns, 2006
PubMed
Additional analysis is available at genomics.betacell.org
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Retrieve list of genes expressed in fetal pancreas that have an expression level
≥2, ≥3, ≥4, -
Retrieve list of genes expressed in adult pancreas and islets that have an expression level
≥2, ≥3, ≥4 -
Retrieve list of genes that are differentially expressed in the pancreas that have a differential value of
-4, -3, -2, -1, 0, 1, 2, 3, 4
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