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TRAFEX - TRAnscription Factor EXpression survey

What can I do with TRAFEX?

TRAFEX tutorial A description, tutorial and FAQ will soon be available. Click here for a sample search for PTF1A, IPF1, NeuroD1 and Neurog3

TRAFEX is a searchable database of gene expression data. To begin using TRAFEX, scroll down to the the three search options: Predefined Search, Simple Search, and Complex Search. All settings are saved as you navigate from one search option to another.

A global survey of RNA from 14 fetal and 12 adult human organs by RT-PCR determined the expression patterns of 790 genes encoding DNA-binding transcription factors. The data can be searched and sorted to identify sets of transcription factors with expression restricted to a given organ or to particular organ groups. These data are a resource to help define the spectrum of transcription factor control, contribute to the elucidation of transcription factor cascades responsible for the development and maintenance of each organ, and provide a baseline to study the effects of disease or developmental defects.

Contributed by Dr. Ray MacDonald, as published: Kong YM, MacDonald RJ, Wen X, Yang P, Barbera VM, Swift GH. A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs. Gene Expr Patterns, 2006 pubmed PubMed

Additional analysis is available at genomics.betacell.org


  • Retrieve list of genes expressed in fetal pancreas that have an expression level
    ≥2, ≥3, ≥4,
  • Retrieve list of genes expressed in adult pancreas and islets that have an expression level
    ≥2, ≥3, ≥4
  • Retrieve list of genes that are differentially expressed in the pancreas that have a differential value of
    -4, -3, -2, -1, 0, 1, 2, 3, 4

Symbol TF Family Stage CNT 34 CNT 234  
         
ABLIM1 LIM ADULT 2 2 3 3
ABLIM3 LIM ADULT 1 2 2 3
ADNP HD ADULT 2 2 3 3
AGGF1 FH ADULT 2 2 3 3
AHR HLH ADULT 1 2 3 2
APBB1 STAT ADULT 1 1 0 3
AR NR ADULT 0 1 2 0
ARID5A MISC ADULT 1 2 2 3
ARNT HLH ADULT 1 2 3 2
ARNTL HLH ADULT 2 2 3 3
ARNTL2 HLH ADULT 0 1 0 2
ASH1L MISC ADULT 2 2 3 3
ATF1 BZIP ADULT 2 2 3 3
ATF2 BZIP ADULT 2 2 3 3
ATF3 BZIP ADULT 2 2 3 3
ATF5 BZIP ADULT 2 2 3 3
ATF6 BZIP ADULT 2 2 3 3
ATF7 BZIP ADULT 1 2 3 2
ATOH7 HLH ADULT 0 0 1
ATRX RING ADULT 2 2 3 3