BCBC Core Facilities
A BCBC Core is a BCBC Investigator-supervised project that is funded for the purpose of supporting and/or facilitating research activities by multiple BCBC Investigators and Co-Investigators. BCBC Cores may be organized and funded to facilitate virtually any research activity in the BCBC although it is expected that these activities will generally fall into one of two categories: (1) provision of complex, personnel- or equipment-dependent services that lend themselves to centralization, and (2) the development of reagents that are essential to the scientific progress of multiple investigators.
BCBC Antibody Core
Director: Ole Madsen
The Core services the BCBC community by developing monoclonal antibodies directed against cell surface antigens (mouse and human). Such antibodies will allow for the unambiguous identification of the distinct cell lineages which arise during ESC development and subsequent maturation into hormone-producing endocrine cells. Monoclonal antibodies that recognize distinct subpopulations of pancreatic cells will be useful for isolating specific cell types and in both cell targeting and cell imaging of the pancreas.
BCBC Mouse / ES Cell Core
Director: Mark Magnuson
The Core services the BCBC by generating new mouse models and mESCs with practical applications in the study of pancreas development and/or regeneration. These reagents are generated primarily via gene targeting and Recombinase Mediated Cassette Exchange (RMCE) approaches.
Cell Transplantation and Assessment Core
The Core services the BCBC community by assessing the function of transplanted human progenitor cells to secrete insulin in vitro and in vivo in response to glucose and to restore normoglycemia in hyperglycemic immunodeficient mice. The Core will also perform research and development activities in an effort to develop standardized assessment procedures that will provide quantifiable metrics for transplanted “beta-like” cells.
This page was last updated on February 21, 2013.