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Cooperative Agreement Funding Mechanism

The NIDDK, through the BCBC Cooperative Agreement funding mechanisms, supports a wide range of research projects focused on understanding the underlying mechanisms of beta cell development, stem cell biology, and beta cell regeneration, with the overarching goal of developing cellular therapies for Type 1 diabetes.

The RFA page for current funding cycle is available.

View the U01 Deliverables. Please note that you must be a BCBC Investigator or a member of the Executive Committee to access this page.


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Project Descriptions (17 Grants)

Lead grant investigators are flagged with a yellow star, Team Leader.

Architecture and communication controlling the efficient generation of beta cells (U01)



Beta Cell Regeneration by Reprogramming of Adult Pancreatic Cells (U01)

Project Investigator:



Coordinating Center for Beta Cell Biology Consortium (U01)



Epigenetic and chemical approaches to generate function beta cells (U01)

Project Investigator:



Epigenetic and Genetic Control of Human and Murine Beta Cell Development and Fate (U01)



Epigenetic regulation and enhancement of beta cell differentiation (U01)

Project is no longer active.

Project Investigator:



Epigenetic strategies for the in vitro generation of replacement beta cells (U01)



Epigenomics of the regenerating and aging beta-cell (U01)

Project is no longer active.

Project Investigators:



Expanding beta-cell mass (U01)



Formation of endocrine pancreas progenitors (U01)



Generation of functional beta cells from stem and progenitor cells (U01)



Genetic control of pancreatic endocrine cell development (U01)



Molecular Mechanisms of Human and Murine Beta Cell Proliferation and Regeneration (U01)



Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication (U01)

Project Investigators:



Novel Sources of Transplantable Beta-cell Replacements (U01)



Regenerating Beta Cells by Lineage Reprogramming (U01)

Project Investigators:



Signaling and Epigenetic Control of Beta Cell Development and Regeneration (U01)

Project is no longer active.