Galvin Swift, Ph.D.

Associate Professor
UT Southwestern Medical Cent.
Molecular Biology

NA6.308 MC9148 6000 Hines Blvd.
Dallas, TX 75390-9148

p. 214-648-1942
· email

Galvin Swift, Ph.D. - Affiliate Profile

My research focuses on the transcription factors directing pancreatic development. Recent work in the lab on the roles of PTF1 and Lrh1 has taken advantage of engineered gene mutations as well as ChIP-seq and RNA-seq to determine all the gene targets of each.

Scientific Interests/Keywords

PTF1, Pdx1, Lrh1, multi-potent progenitor cells

Affiliate of

MacDonald Lab

Publications

Publication	Citation
21852532	Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. (2011) Genes Dev 25: 1674-9 (Added 2012-02-17 14:44:25.983808)
21074728	MacDonald RJ, Swift GH, Real FX Transcriptional control of acinar development and homeostasis. (2010) Prog Mol Biol Transl Sci 97: 1-40 (Added 2011-08-30 16:47:43.500481)
20398665	Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. (2010) Gastroenterology 139: 270-80 (Added 2013-04-23 09:40:34.426046)
19741120	Meredith DM, Masui T, Swift GH, MacDonald RJ, Johnson JE Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex. (2009) J Neurosci 29: 11139-48 (Added 2010-01-18 12:01:35.13984)
18606784	Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. (2008) Mol Cell Biol 28: 5458-68 (Added 2010-01-18 12:01:35.154665)
16487753	Kong YM, Macdonald RJ, Wen X, Yang P, Barbera VM, Swift GH A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs. (2006) Gene Expr Patterns 6: 678-86 (Added 2010-01-18 12:01:35.157712)
16354684	Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. (2006) Mol Cell Biol 26: 117-30 (Added 2010-01-18 12:01:35.160515)
12972592	Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. (2003) Mol Cell Biol 23: 6713-24 (Added 2010-01-18 12:01:35.163593)
11562365	Rose SD, Swift GH, Peyton MJ, Hammer RE, MacDonald RJ The role of PTF1-P48 in pancreatic acinar gene expression. (2001) J Biol Chem 276: 44018-26 (Added 2010-01-18 12:01:35.166536)
11279116	Liu Y, MacDonald RJ, Swift GH DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. (2001) J Biol Chem 276: 17985-93 (Added 2010-01-18 12:01:35.169525)
10995768	Viswanath RL, Rose SD, Swift GH, MacDonald RJ A binary mechanism for the selective action of a pancreatic beta -cell transcriptional silencer. (2000) J Biol Chem 275: 40273-81 (Added 2010-01-18 12:01:35.172519)
9710595	Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM, Wright CV, MacDonald RJ An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). (1998) Mol Cell Biol 18: 5109-20 (Added 2010-01-18 12:02:32.241704)
8175694	Swift GH, Rose SD, MacDonald RJ An element of the elastase I enhancer is an overlapping bipartite binding site activated by a heteromeric factor. (1994) J Biol Chem 269: 12809-15 (Added 2010-01-18 12:02:32.24997)
8114736	Rose SD, Kruse F, Swift GH, MacDonald RJ, Hammer RE A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut. (1994) Mol Cell Biol 14: 2048-57 (Added 2010-01-18 12:02:32.253166)
7684006	Kruse F, Rose SD, Swift GH, Hammer RE, MacDonald RJ An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer. (1993) Genes Dev 7: 774-86 (Added 2010-01-18 12:02:32.256307)
7623833	Kruse F, Rose SD, Swift GH, Hammer RE, MacDonald RJ Cooperation between elements of an organ-specific transcriptional enhancer in animals. (1995) Mol Cell Biol 15: 4385-94 (Added 2010-01-18 12:02:32.246934)
6567483	Swift GH, Hammer RE, MacDonald RJ, Brinster RL Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. (1984) Cell 38: 639-46 (Added 2010-01-18 12:04:21.199687)
3844051	Ornitz DM, Palmiter RD, Hammer RE, Brinster RL, Swift GH, MacDonald RJ Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. (1985) Nature 313: 600-2 (Added 2010-01-18 12:04:21.189421)
3670302	Hammer RE, Swift GH, Ornitz DM, Quaife CJ, Palmiter RD, Brinster RL, MacDonald RJ The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. (1987) Mol Cell Biol 7: 2956-67 (Added 2010-01-18 12:02:32.26262)
3541749	MacDonald RJ, Hammer RE, Swift GH, Ornitz DM, Davis BP, Palmiter RD, Brinster RL Tissue-specific expression of pancreatic genes in transgenic mice. (1986) Ann N Y Acad Sci 478: 131-46 (Added 2010-01-18 12:04:21.183843)
3295992	MacDonald RJ, Swift GH, Hammer RE, Ornitz DM, Davis BP, Brinster RL, Palmiter RD Targeted expression of cloned genes in transgenic mice. (1987) Prog Brain Res 71: 3-12 (Added 2010-01-18 12:02:32.265624)
2744460	Swift GH, Kruse F, MacDonald RJ, Hammer RE Differential requirements for cell-specific elastase I enhancer domains in transfected cells and transgenic mice. (1989) Genes Dev 3: 687-96 (Added 2010-01-18 12:02:32.259465)
2443794	MacDonald RJ, Swift GH, Przybyla AE, Chirgwin JM Isolation of RNA using guanidinium salts. (1987) Methods Enzymol 152: 219-27 (Added 2010-01-18 12:02:32.268635)