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Philip Streeter, Ph.D.

Associate Professor
Oregon Health & Science University
Pediatrics

3181 SW Sam Jackson Park RoadMail code L321
Portland, OR 97239-3098
USA

p. 503-494-1762
f. 503-418-5044
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Philip Streeter, Ph.D. - Investigator Profile

Dr. Streeter received his B.S. from the University of California-Davis in 1977.  He attended graduate school at Kansas State University, receiving an M.S. in Laboratory Medicine in 1980 and a Ph.D. in Microbiology in 1985.  Dr. Streeter continued his studies as a Postdoctoral Fellow in the Department of Pathology at Stanford University, investigating the molecular mechanisms involved in leukocyte recruitment to diverse lymphoid and extralymphoid tissues.  In 1989 Dr. Streeter joined the biotechnology company SyStemix Inc., Palo Alto, CA, and moved to St. Louis, MO, in 1992 to work at Searle/Monsanto, now Pfizer.  While working in these companies, Dr. Streeter led research efforts in the engineering of hematopoietic cytokines, the development of anti-tumor vaccines, and the identification of selective inhibitors of autoimmune disease. 

In 2000, Dr. Streeter joined Oregon Health & Science University and he is currently an Associate Professor in the Department of Pediatrics.  In 2003 he became Director of the OHSU Hematopoietic Cell Processing Laboratory, and in 2004 he became a member of the Oregon Stem Cell Center, where he is Director of the Center''s monoclonal antibody and flow cytometry core facilities.

The research goals of the Streeter laboratory are to contribute to the emerging fields of tissue engineering/repair and the development of reagents for cancer diagnosis/therapy.  Areas of research focus are beta cell replacement therapies for the treatment of diabetes, the identification of lung progenitor cell populations involved in lung repair, and in the diagnosis and treatment of GI cancers.

Scientific Interests/Keywords

Tissue engineering, tissue repair, lung progenitor cells, pancreatic cancer

Associate Professor, Streeter Lab

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Publication Citation
21539888 Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. (2011) Mol Cell Endocrinol 339: 144-50 (Added 2013-03-14 16:24:18.452249)
21361360 Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. (2011) Mol Pharm 8: 767-73 (Added 2012-08-24 07:30:50.716163)
20423988 Adkisson HD, Martin JA, Amendola RL, Milliman C, Mauch KA, Katwal AB, Seyedin M, Amendola A, Streeter PR, Buckwalter JA The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. (2010) Am J Sports Med 38: 1324-33 (Added 2010-08-27 17:12:49.14836)
19880363 Adkisson HD, Milliman C, Zhang X, Mauch K, Maziarz RT, Streeter PR Immune evasion by neocartilage-derived chondrocytes: Implications for biologic repair of joint articular cartilage. (2010) Stem Cell Res 4: 57-68 (Added 2010-08-27 17:12:49.153428)
19522011 Gadue P, Gouon-Evans V, Cheng X, Wandzioch E, Zaret KS, Grompe M, Streeter PR, Keller GM Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. (2009) Stem Cells 27: 2103-13 (Added 2012-03-09 17:04:25.001995)
19383399 Dorrell C, Abraham SL, Lanxon-Cookson KM, Canaday PS, Streeter PR, Grompe M Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. (2008) Stem Cell Res 1: 183-94 (Added 2011-12-06 15:02:30.596077)
19043576 Jiang S, Bailey AS, Goldman DC, Swain JR, Wong MH, Streeter PR, Fleming WH Hematopoietic stem cells contribute to lymphatic endothelium. (2008) PLoS One 3: e3812 (Added 2010-08-27 17:12:49.165099)
19022422 Kovacsovics-Bankowski M, Streeter PR, Mauch KA, Frey MR, Raber A, van't Hof W, Deans R, Maziarz RT Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease. (2009) Cell Immunol 255: 55-60 (Added 2010-08-27 17:12:49.168886)
18985479 Kovacsovics-Bankowski M, Mauch K, Raber A, Streeter PR, Deans RJ, Maziarz RT, Van't Hof W Pre-clinical safety testing supporting clinical use of allogeneic multipotent adult progenitor cells. (2008) Cytotherapy 10: 730-42 (Added 2010-08-27 17:12:49.172764)
18726953 Dorrell C, Erker L, Lanxon-Cookson KM, Abraham SL, Victoroff T, Ro S, Canaday PS, Streeter PR, Grompe M Surface markers for the murine oval cell response. (2008) Hepatology 48: 1282-91 (Added 2011-12-06 15:03:33.029965)
15849171 Anderson DA, Wu Y, Jiang S, Zhang X, Streeter PR, Spangrude GJ, Archer DR, Fleming WH Donor marker infidelity in transgenic hematopoietic stem cells. (2005) Stem Cells 23: 638-43 (Added 2010-08-27 17:12:49.180197)
15111929 Streeter PR, Zhang X, Tittle TV, Schön CN, Weinberg AD, Maziarz RT CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 (OX40) T-cell subsets in acute graft-versus-host disease. (2004) Biol Blood Marrow Transplant 10: 298-309 (Added 2010-08-27 17:14:32.086131)
14585378 Streeter PR, Dudley LZ, Fleming WH Activation of the G-CSF and Flt-3 receptors protects hematopoietic stem cells from lethal irradiation. (2003) Exp Hematol 31: 1119-25 (Added 2010-08-27 17:14:32.091671)
11495700 Fleming WH, Mulcahy JM, McKearn JP, Streeter PR Progenipoietin-1: a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3 is a potent mobilizer of hematopoietic stem cells. (2001) Exp Hematol 29: 943-51 (Added 2010-08-27 17:14:32.096141)
11164104 Streeter PR, Minster NI, Kahn LE, Hood WF, Vickery LE, Thurman TL, Monahan JB, Welply JK, McKearn JP, Woulfe SL Progenipoietins: biological characterization of a family of dual agonists of fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor. (2001) Exp Hematol 29: 41-50 (Added 2010-08-27 17:14:32.099952)
1804780 McCune JM, Péault B, Streeter PR, Rabin L Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse. (1991) Immunol Rev 124: 45-62 (Added 2011-08-31 16:06:54.589503)
Resource ID Name Contributed on Primary Contributor
326 Monoclonal Human Pancreatic endocrine cells raised in Mouse Jul 14, 2006
327 Monoclonal Human Pancreatic endocrine cells raised in Mouse Jul 14, 2006
328 Monoclonal Human Pancreatic endocrine cells raised in Mouse Jul 14, 2006
329 Monoclonal Human Pancreatic endocrine cells raised in Mouse Jul 14, 2006
330 Monoclonal Human Pancreatic endocrine cells raised in Mouse Jul 14, 2006
337 Monoclonal Human Pancreatic duct cells raised in Mouse Oct 17, 2007
338 Monoclonal Human Pancreatic duct cells raised in Mouse Oct 17, 2007
339 Monoclonal Human Pancreatic exocrine cells raised in Mouse Oct 17, 2007
340 Monoclonal Human Pancreatic exocrine cells raised in Mouse Oct 18, 2007
341 Monoclonal Human Pancreatic endocrine cells raised in Mouse Oct 18, 2007
342 Monoclonal Human Alpha cells raised in Mouse Oct 18, 2007
343 Monoclonal Human Alpha cells raised in Mouse Oct 18, 2007
344 Monoclonal Mouse Mo ES-Derived Definitive Endoderm raised in Rat Dec 19, 2007
345 Monoclonal Mouse Mo ES-Derived Definitive Endoderm raised in Rat Dec 19, 2007
901 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
903 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
904 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
905 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
906 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
907 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
908 Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat Feb 10, 2009
921 Monoclonal Human Hu ES-Derived Early Endoderm raised in Mouse Feb 10, 2009
922 Monoclonal Human Hu ES-Derived Early Endoderm raised in Mouse Feb 10, 2009
941 Monoclonal Human Hu ES-Derived Early Endoderm raised in Mouse Feb 10, 2009
942 Monoclonal Mouse Pancreatic duct cells raised in Rat Feb 10, 2009
943 Monoclonal Mouse Pancreatic duct and acinar cells raised in Rat Feb 10, 2009
944 Monoclonal Mouse Pancreatic endocrine cells raised in Rat Feb 10, 2009
945 Monoclonal Mouse Endothelial cells raised in Rat Feb 11, 2009
4573 Monoclonal Human Gallbladder mucosal epithelium raised in Mouse Mar 12, 2013
4574 Monoclonal Human Gallbladder mucosal epithelium raised in Mouse Mar 12, 2013
4575 Monoclonal Human Gallbladder mucosal epithelium raised in Mouse Mar 12, 2013
4576 Monoclonal Human Gallbladder mucosal epithelium raised in Mouse Mar 12, 2013
32 completed resources viewable