Benjamin Glaser, M.D.
Head, Endocrinology and Metabolism Service
Hadassah-Hebrew University Medical Center
Endocrinology and Metabolism
Endocrinology Department, Hadassah Hospital POB 12000
p. 972 2 6776599
f. (+972) 2 643 79
Benjamin Glaser, M.D. - Co-investigator Profile
My primary research interests can be divided into 3 topics. The first focuses on monogenic diseases of the beta-cell, particularly Congenital Hyperinsulinemia of Infancy (CHI or PHHI), a syndrome of beta-cell hyperfunction characterized by increased insulin secretion and hypoglycemia. My group was instrumental in identifying some of the genetic causes of this syndrome, and we are on the lookout for new cases with novel genetic etiologies. In addition to providing genetic diagnosis, we are using this information to try and better understand human beta-cell physiology with the ultimate goal of developing novel therapeutic concepts. The second relates to the genetics of type 2 diabetes and diabetic complications. We are collaborators in a number of studies, including a large, NIH-sponsored international consortium aimed at identifying the causal mutations responsible for GWAS risk signals. Recent publications have included collaborative studies on epigenetic risk factors for diabetes. The third focus is beta-cell replication and survival, leveraging lessons learned from the genetic studies mentioned above to manipulate replication in human beta-cells. These studies yielded a recent Cell Metabolism paper along with Prof. Yuval Dor, and an ongoing BCBC project in collaboration with Dr. Klaus Kaestner.
Monogenic beta-cell disease, Genetics of Type 2 Diabetes, Beta-cell survival, Beta-cell replication