Benjamin Glaser, M.D.

Head, Endocrinology and Metabolism Service
Hadassah-Hebrew University Medical Center
Endocrinology and Metabolism

Endocrinology Department, Hadassah Hospital POB 12000
Jerusalem, 91120
Israel

p. 972 2 6776599
f. (+972) 2 643 79
· email

Benjamin Glaser, M.D. - Co-investigator Profile

My primary research interests can be divided into 3 topics. The first focuses on monogenic diseases of the beta-cell, particularly Congenital Hyperinsulinemia of Infancy (CHI or PHHI), a syndrome of beta-cell hyperfunction characterized by increased insulin secretion and hypoglycemia. My group was instrumental in identifying some of the genetic causes of this syndrome, and we are on the lookout for new cases with novel genetic etiologies. In addition to providing genetic diagnosis, we are using this information to try and better understand human beta-cell physiology with the ultimate goal of developing novel therapeutic concepts. The second relates to the genetics of type 2 diabetes and diabetic complications. We are collaborators in a number of studies, including a large, NIH-sponsored international consortium aimed at identifying the causal mutations responsible for GWAS risk signals. Recent publications have included collaborative studies on epigenetic risk factors for diabetes. The third focus is beta-cell replication and survival, leveraging lessons learned from the genetic studies mentioned above to manipulate replication in human beta-cells. These studies yielded a recent Cell Metabolism paper along with Prof. Yuval Dor, and an ongoing BCBC project in collaboration with Dr. Klaus Kaestner.

Scientific Interests/Keywords

Monogenic beta-cell disease, Genetics of Type 2 Diabetes, Beta-cell survival, Beta-cell replication

Head, Endocrinology and Metabolism Service, Glaser Lab

Publications
Contributions

Publication	Citation
21994764	Toperoff G, Aran D, Kark JD, Rosenberg M, Dubnikov T, Nissan B, Wainstein J, Friedlander Y, Levy-Lahad E, Glaser B, Hellman A Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. (2012) Hum Mol Genet 21: 371-83 (Added 2012-03-13 04:20:43.52952)
21521747	Salpeter SJ, Klochendler A, Weinberg-Corem N, Porat S, Granot Z, Shapiro AM, Magnuson MA, Eden A, Grimsby J, Glaser B, Dor Y Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels. (2011) Endocrinology 152: 2589-98 (Added 2012-03-13 04:21:04.375557)
21459328	Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y Control of pancreatic β cell regeneration by glucose metabolism. (2011) Cell Metab 13: 440-9 (Added 2012-03-15 14:16:44.029117)
20375417	Kassem S, Bhandari S, Rodríguez-Bada P, Motaghedi R, Heyman M, García-Gimeno MA, Cobo-Vuilleumier N, Sanz P, Maclaren NK, Rahier J, Glaser B, Cuesta-Muñoz AL Large islets, beta-cell proliferation, and a glucokinase mutation. (2010) N Engl J Med 362: 1348-50 (Added 2012-03-13 04:29:34.460388)
20361036	Neuman RJ, Wasson J, Atzmon G, Wainstein J, Yerushalmi Y, Cohen J, Barzilai N, Blech I, Glaser B, Permutt MA Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population. (2010) PLoS One 5: e9903 (Added 2012-03-13 04:21:39.545178)
17603484	Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, Blech I, Pharoah PD, Palmer CN, Kimber C, Tavendale R, Morris AD, McCarthy MI, Walker M, Hitman G, Glaser B, Permutt MA, Hattersley AT, Wareham NJ, Barroso I Common variants in WFS1 confer risk of type 2 diabetes. (2007) Nat Genet 39: 951-3 (Added 2012-03-13 04:23:36.894753)
15696192	Potikha T, Kassem S, Haber EP, Ariel I, Glaser B p57Kip2 (cdkn1c): sequence, splice variants and unique temporal and spatial expression pattern in the rat pancreas. (2005) Lab Invest 85: 364-75 (Added 2012-03-13 04:29:42.217559)
12475768	Permutt MA, Wasson J, Love-Gregory L, Ma J, Skolnick G, Suarez B, Lin J, Glaser B Searching for type 2 diabetes genes on chromosome 20. (2002) Diabetes 51 Suppl 3: S308-15 (Added 2012-03-13 04:24:23.792632)
11723059	Kassem SA, Ariel I, Thornton PS, Hussain K, Smith V, Lindley KJ, Aynsley-Green A, Glaser B p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy. (2001) Diabetes 50: 2763-9 (Added 2012-03-13 04:24:31.37332)
11246891	Permutt MA, Wasson JC, Suarez BK, Lin J, Thomas J, Meyer J, Lewitzky S, Rennich JS, Parker A, DuPrat L, Maruti S, Chayen S, Glaser B A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population. (2001) Diabetes 50: 681-5 (Added 2012-03-13 04:24:55.756666)
10973248	Bitner-Glindzicz M, Lindley KJ, Rutland P, Blaydon D, Smith VV, Milla PJ, Hussain K, Furth-Lavi J, Cosgrove KE, Shepherd RM, Barnes PD, O'Brien RE, Farndon PA, Sowden J, Liu XZ, Scanlan MJ, Malcolm S, Dunne MJ, Aynsley-Green A, Glaser B A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene. (2000) Nat Genet 26: 56-60 (Added 2012-03-13 06:32:31.08459)
10923633	Kassem SA, Ariel I, Thornton PS, Scheimberg I, Glaser B Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. (2000) Diabetes 49: 1325-33 (Added 2012-03-13 04:25:05.641327)
10193261	Ryan F, Devaney D, Joyce C, Nestorowicz A, Permutt MA, Glaser B, Barton DE, Thornton PS Hyperinsulinism: molecular aetiology of focal disease. (1998) Arch Dis Child 79: 445-7 (Added 2012-03-13 04:32:18.512749)
9398842	Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, Green ED Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). (1997) Nat Genet 17: 411-22 (Added 2012-03-13 04:35:56.738791)
8650576	Nichols CG, Shyng SL, Nestorowicz A, Glaser B, Clement JP, Gonzalez G, Aguilar-Bryan L, Permutt MA, Bryan J Adenosine diphosphate as an intracellular regulator of insulin secretion. (1996) Science 272: 1785-7 (Added 2012-03-13 04:32:36.5958)
8630498	Sheffield VC, Kraiem Z, Beck JC, Nishimura D, Stone EM, Salameh M, Sadeh O, Glaser B Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification. (1996) Nat Genet 12: 424-6 (Added 2012-03-13 04:36:13.183111)
7920639	Glaser B, Chiu KC, Anker R, Nestorowicz A, Landau H, Ben-Bassat H, Shlomai Z, Kaiser N, Thornton PS, Stanley CA Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene. (1994) Nat Genet 7: 185-8 (Added 2012-03-13 04:26:38.650811)

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