James Wells, PhD - Co-investigator Profile
Our research is focused on understanding the molecular basis of development of endodermal organs that are central to endocrine homeostasis, the pancreas and intestine. We have identified several important signaling pathways that direct transcriptional responses that are central to the development of these organs. We now use the basic principles of endoderm organ development as a molecular framework for several projects that are designed to improve child health: 1. Identifying the cause of congenital defects affecting endodermal organs. 2. Directing the differentiation of human embryonic and induced pluripotent stem cells (iPSCs) into pancreatic and intestinal tissue for basic research and eventual transplantation-based therapies for Diabetes. 3. Identifying molecular pathways involved in postnatal homeostasis and diseases affecting these important organ systems.
Endoderm organogenesis, human pluripotent stem cells, endocrine cell development, metabolic disease, Diabetes