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Chris Newgard, Ph.D.

Professor
Duke University Medical Center
Pharmacology and Cancer Biology

4321 Medical Park Drive, Suite 200
Durham, NC 27704
USA

p. 919-668-6059
f. 919-477-0632
· email
· website

Chris Newgard, Ph.D. - Investigator Profile

Our laboratory focuses on understanding of metabolic regulatory mechanisms, and the application of this knowledge for gaining insights into chronic conditions and diseases such as obesity and diabetes. Key projects in the lab include: 1) Molecular and biochemical mechanisms of fuel-mediated insulin secretion and their impairment in obesity and diabetes; 2) Mechanisms of pancreatic beta-cell growth and survival; 3) Regulation of glucose and lipid metabolism in liver; 4) Mechanisms by which metabolic alterations in liver affect peripheral (e.g muscle) fuel metabolism. The laboratory employs a highly interdisciplinary approach to each of these projects, including gene discovery (microarray analysis), genetic engineering, enzymology and biochemistry, and state-of-the-art tools for metabolic analysis including flux measurements by stable isotope NMR and metabolic profiling by mass spectrometry. In his role as Director of the Sarah W. Stedman Nutrition and Metabolism Center, Dr. Newgard has also formed a clinical research team that is applying comprehensive metabolic and biomarker profiling to obese humans as they lose weight by eight different interventions that are available on the Duke campus or in the surrounding community.

Scientific Interests/Keywords

metabolic regulatory mechanisms

Professor, Newgard Lab

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Click to view the profile for Hans Hohmeier, M.D., Ph.D..
Publication Citation
15983211 Samli KN, McGuire MJ, Newgard CB, Johnston SA, Brown KC Peptide-mediated targeting of the islets of langerhans. (2005) Diabetes 54: 2103-8 (Added 2005-08-16 15:31:06)
15883383 Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB The Nkx6.1 homeodomain transcription factor suppresses glucagon expression (2005) Proc Natl Acad Sci U S A 102: 7297-302 (Added 2005-08-16 15:31:27)
15743769 Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG Mechanism of insulin gene regulation by the pancreatic transcription (2005) J Biol Chem 280: 16798-807 (Added 2005-08-16 15:31:52)
15331526 Bain JR, Schisler JC, Takeuchi K, Newgard CB, Becker TC An adenovirus vector for efficient RNA interference-mediated suppression (2004) Diabetes 53: 2190-4 (Added 2005-08-16 15:32:15)
15073188 Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB Biochemical mechanism of lipid-induced impairment of glucose-stimulated (2004) J Biol Chem 279: 27263-71 (Added 2005-08-16 15:32:36)
14770177 An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and (2004) Nat Med 10: 268-74 (Added 2005-08-16 15:32:55)
12852853 Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM Suppression of beta cell energy metabolism and insulin release by (2003) Dev Cell 5: 73-83 (Added 2005-08-16 15:33:20)
12765953 Tran VV, Chen G, Newgard CB, Hohmeier HE Discrete and complementary mechanisms of protection of beta-cells against (2003) Diabetes 52: 1423-32 (Added 2005-08-16 15:33:47)
12401704 Newgard CB While tinkering with the beta-cell...metabolic regulatory mechanisms and (2002) Diabetes 51: 3141-50 (Added 2005-08-16 15:34:04)
11880625 Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD 13C NMR isotopomer analysis reveals a connection between pyruvate cycling (2002) Proc Natl Acad Sci U S A 99: 2708-13 (Added 2005-08-16 15:34:19)
Resource ID Name Contributed on Primary Contributor
350 RNAi.Firefly.PPYLUC.HI RNA Sep 27, 2006 Yes
351 RNAi.Unclassified.scrambled.Rat Insulin I Sep 27, 2006 Yes
352 RNAi.Unclassified.scrambled.HI RNA Sep 27, 2006 Yes
353 RNAi.Rat.GCK.HI RNA Sep 27, 2006 Yes
354 RNAi.Rat.Slc2a2; GLUT2.HI RNA Sep 27, 2006 Yes
355 RNAi.Rat.Nkx6.1.HI RNA Sep 27, 2006 Yes
356 RNAi.Rat.schad, Hadhsc.HI RNA Sep 27, 2006 Yes
357 RNAi.Rat.schad, Hadhsc.HI RNA Sep 27, 2006 Yes
358 RNAi.Rat.Acaca; ACC1.HI RNA Sep 27, 2006 Yes
359 RNAi.Rat.Acacb; ACC2.HI RNA Sep 27, 2006 Yes
360 RNAi.Rat.GcgR.HI RNA Sep 27, 2006 Yes
361 RNAi.Rat.GcgR.rat insulin I Sep 27, 2006 Yes
362 RNAi.Rat.Idh1; ICDc.HI RNA Sep 27, 2006 Yes
363 RNAi.Rat.Idh1; ICDc.HI RNA Sep 27, 2006 Yes
364 RNAi.Rat.Ldhd.HI RNA Sep 27, 2006 Yes
365 RNAi.Rat.Cpt1a.CPT I Sep 27, 2006 Yes
366 RNAi.Rat.ME2.HI RNA Sep 27, 2006 Yes
367 RNAi.Rat.ME2.HI RNA Sep 27, 2006 Yes
368 RNAi.Rat.ME2.rat insulin I Sep 27, 2006 Yes
369 RNAi.Rat.ME2.rat insulin I Sep 27, 2006 Yes
370 RNAi.Rat.ME1.HI RNA Sep 27, 2006 Yes
371 RNAi.Rat.Slc25a10; DIC.HI RNA Sep 27, 2006 Yes
372 RNAi.Rat.Slc25a1; CIC.HI RNA Sep 27, 2006 Yes
373 RNAi.Rat.Pdx1; Idx1; Ipf1; Stf1.HI RNA Sep 27, 2006 Yes
376 RNAi.Human.PSARL.HI RNA Sep 27, 2006 Yes
377 RNAi.Rat.PC; Pcx.HI RNA Sep 27, 2006 Yes
378 RNAi.Rat.PC; Pcx.rat insulin I Sep 27, 2006 Yes
379 RNAi.Human.GPR40.HI RNA Sep 27, 2006 Yes
380 RNAi.Rat.PDK1.HI RNA Sep 27, 2006 Yes
381 RNAi.Rat.PDK2.HI RNA Sep 27, 2006 Yes
382 RNAi.Rat.Gast; Gas; PPG34.HI RNA Sep 27, 2006 Yes
383 RNAi.Rat.Tgfa.rat insulin I Sep 27, 2006 Yes
384 RNAi.Rat.Glp1r.HI RNA Sep 27, 2006 Yes
385 RNAi.Rat.HIBADH.HI RNA Sep 27, 2006 Yes
388 RNAi.Rat.SOCS-3; Cish3; Socs-3; Ssi-3.HI RNA Sep 27, 2006 Yes
390 OE.Unclassified.lacZ.CMV Sep 27, 2006 Yes
391 OE.Jellyfish.EGFP.CMV Sep 27, 2006 Yes
392 OE.Rat.HK 1.CMV Sep 27, 2006 Yes
393 OE.Rat.Gck; GLUKA; RNGK2.CMV Sep 27, 2006 Yes
394 OE.Rat.Gck; GLUKA; RNGK2.CMV Sep 27, 2006 Yes
395 OE.Rat.Gck; GLUKA; RNGK2.CMV Sep 27, 2006 Yes
396 OE.Human.GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2.CMV Sep 27, 2006 Yes
397 OE.Human.GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2.CMV Sep 27, 2006 Yes
398 OE.Human.GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2.CMV Sep 27, 2006 Yes
399 OE.Human.GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2.CMV Sep 27, 2006 Yes
400 OE.Human.GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2.CMV Sep 27, 2006 Yes
401 OE.Human.GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2.CMV Sep 27, 2006 Yes
402 OE.Rat.G6pc; G6Pase.CMV Sep 27, 2006 Yes
403 OE.Human.G6PT1; SLC37A4.CMV Sep 27, 2006 Yes
404 OE.Rat.LDHA, rat.CMV Sep 27, 2006 Yes
405 OE.Rat.Ldhd.CMV Sep 27, 2006 Yes
406 OE.Unclassified.HSL.CMV Sep 27, 2006 Yes
407 OE.Rat.UCP2.CMV Sep 27, 2006 Yes
408 OE.Unclassified.CPT1.CMV Sep 27, 2006 Yes
409 OE.Unclassified.Glut1.CMV Sep 27, 2006 Yes
410 OE.Rat.OXCT1; SCOT.CMV Sep 27, 2006 Yes
411 OE.Rat.DBI.CMV Sep 27, 2006 Yes
412 OE.Unclassified.ACS-1.CMV Sep 27, 2006 Yes
413 OE.Rat.ICDc.CMV Sep 27, 2006 Yes
414 OE.Rat.ICDc.CMV Sep 27, 2006 Yes
415 OE.Rat.H6PD; GDH; G6PDH.CMV Sep 27, 2006 Yes
416 OE.Duck.ME1.CMV Sep 27, 2006 Yes
417 OE.Human.ME2.CMV Sep 27, 2006 Yes
418 OE.Human.MLYCD; MCD.CMV Sep 27, 2006 Yes
419 OE.Human.MLYCD; MCD.CMV Sep 27, 2006 Yes
420 OE.Human.MLYCD; MCD.CMV Sep 27, 2006 Yes
421 OE.Goose.MLYCD; MCD.CMV Sep 27, 2006 Yes
422 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
423 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
424 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
425 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
426 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
427 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
428 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
429 OE.Rabbit.GM.CMV Sep 27, 2006 Yes
430 OE.Rat.GL.CMV Sep 27, 2006 Yes
431 OE.Rat.GL.CMV Sep 27, 2006 Yes
432 OE.Mouse.PTG.CMV Sep 27, 2006 Yes
433 OE.Mouse.PTG.CMV Sep 27, 2006 Yes
434 OE.Mouse.PTG.CMV Sep 27, 2006 Yes
435 OE.Mouse.PTG.CMV Sep 27, 2006 Yes
436 OE.Mouse.PTG.CMV Sep 27, 2006 Yes
437 OE.Unclassified.MGP.CMV Sep 27, 2006 Yes
438 OE.Unclassified.Gyg; Gyg1.CMV Sep 27, 2006 Yes
439 OE.Rat.lep.tet-inducible Sep 27, 2006 Yes
440 OE.Rat.lep.CMV Sep 27, 2006 Yes
442 OE.Unclassified.INS.CMV Sep 27, 2006 Yes
445 OE.Human.GCGR; GGR.CMV Sep 27, 2006 Yes
446 OE.Human.Glp1r.CMV Sep 27, 2006 Yes
450 OE.Unclassified.alpha1-PL-AMP kinase.CMV Sep 27, 2006 Yes
451 OE.Human.PLCB3.CMV Sep 27, 2006 Yes
452 OE.Rat.PLCB1.CMV Sep 27, 2006 Yes
453 OE.Rat.PLCD1.CMV Sep 27, 2006 Yes
454 OE.Bovine.GaS.CMV Sep 27, 2006 Yes
455 OE.Unclassified.Ga11.CMV Sep 27, 2006 Yes
456 OE.Bovine.GaS.CMV Sep 27, 2006 Yes
457 OE.Rat.GUCY1B3.CMV Sep 27, 2006 Yes
458 OE.Rat.GUCY1B3.CMV Sep 27, 2006 Yes
459 OE.Rat.Stat1a.CMV Sep 27, 2006 Yes
460 OE.Rat.Stat1a.CMV Sep 27, 2006 Yes
461 OE.Rat.MnSOD; Sod2.CMV Sep 27, 2006 Yes
462 OE.Rat.GILZ.CMV Sep 27, 2006 Yes
463 OE.Hamster.Nkx6.1.CMV Sep 27, 2006 Yes
464 OE.Hamster.Nkx6.1.CMV Sep 27, 2006 Yes
465 OE.Hamster.Nkx6.1.CMV Sep 27, 2006 Yes
466 OE.Hamster.Nkx6.1.CMV Sep 27, 2006 Yes
467 OE.Hamster.Nkx6.1.CMV Sep 27, 2006 Yes
475 OE.Rat.Ube2m; UBC12 homolog, yeast.CMV Sep 27, 2006 Yes
476 OE.Rat.Ube2m; UBC12 homolog, yeast.CMV Sep 27, 2006 Yes
477 OE.Mouse.Pdx1; Ipf1; IDX-1; IPF-1; Mody4; Pdx1; STF-1; pdx-1.CMV Sep 27, 2006 Yes
478 OE.Mouse.MafA.CMV Sep 27, 2006 Yes
479 OE.Mouse.MafB.CMV Sep 27, 2006 Yes
480 OE.Rat.ccnb1.CMV Sep 27, 2006 Yes
481 OE.Rat.ccnb1.CMV Sep 27, 2006 Yes
486 OE.Unclassified.tA.CMV Sep 27, 2006 Yes
487 OE.Rat.Tff3.CMV Sep 27, 2006 Yes
489 OE.E. coli.glpK.CMV Sep 27, 2006 Yes
490 RNAi.Rat.Slc2a2; GLUT2.HI RNA Sep 27, 2006 Yes
1032 Cytotoxicity Study of Rat INS1 cell lines Feb 4, 2004 Yes
1075 Stimulation of Human and Rat Islet beta-Cell Proliferation with Retention of Function by Nkx6.1 Nov 10, 2008 Yes
4102 OE.Human.NKX6-1.CMV May 12, 2011 Yes
4103 OE.Human.PDX1.CMV May 12, 2011 Yes
122 completed resources viewable