David Harlan, MD

Co-Director
University of Massachusetts
Diabetes Center of Excellence

55 Lake Avenue North, Room AC4.127
Worcester, MA 01655
USA

p. 508-856-3800
f. 508-856-3811
· email

David Harlan, MD - Investigator Profile

I am interested in identifying the immunological mechanisms that underlie the pathogenesis of type 1 diabetes mellitus (T1DM) and/or the rejection organs/tissues transplanted to treat that disease. To those ends, my group utilizes molecular, cellular, and small animal models to elucidate immunological mechanisms. In addition, I have conducted clinical protocols to test whether immune modifying reagents can ameliorate disease severity in individuals with recently diagnosed T1DM. For the latter, my colleagues and I have developed a non-human primate model to test novel approaches to improve islet transplant technology. We have also developed tests to assess the biology of individual islet cell subsets.

Scientific Interests/Keywords

Pathogenesis of type 1 diabetes mellitus, rejection organs/tissues transplanted with diabetes, exploring beta cell biology

Publication	Citation
20660050	Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, Pechhold S, Liu EH, Harlan DM, Tisdale JF Significant Human {beta}-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating. (2010) J Clin Endocrinol Metab : (Added 2010-08-10 14:55:55.991716)
19838197	Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. (2009) Nat Biotechnol 27: 1038-42 (Added 2012-03-17 01:26:57.109091)
19808924	Rother KI, Spain LM, Wesley RA, Digon BJ, Baron A, Chen K, Nelson P, Dosch HM, Palmer JP, Brooks-Worrell B, Ring M, Harlan DM Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes. (2009) Diabetes Care 32: 2251-7 (Added 2010-08-10 14:55:56.007534)
19794074	Harlan DM, Kenyon NS, Korsgren O, Roep BO, Immunology of Diabetes Society Current advances and travails in islet transplantation. (2009) Diabetes 58: 2175-84 (Added 2010-08-10 14:55:56.011006)
19450275	Craig AT, Gavrilova O, Dwyer NK, Jou W, Pack S, Liu E, Pechhold K, Schmidt M, McAlister VJ, Chiorini JA, Blanchette-Mackie EJ, Harlan DM, Owens RA Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors. (2009) Virol J 6: 61 (Added 2010-08-26 12:19:23.845119)
19418039	Liu EH, Digon BJ, Hirshberg B, Chang R, Wood BJ, Neeman Z, Kam A, Wesley RA, Polly SM, Hofmann RM, Rother KI, Harlan DM Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. (2009) Diabetologia 52: 1369-80 (Added 2010-08-10 14:55:56.020459)
10393960	Kenyon NS, Chatzipetrou M, Masetti M, Ranuncoli A, Oliveira M, Wagner JL, Kirk AD, Harlan DM, Burkly LC, Ricordi C Long-term survival and function of intrahepatic islet allografts in rhesus (1999) Proc Natl Acad Sci U S A 96: 8132-7 (Added 2005-04-13 13:03:50)

Resource ID	Name	Contributed on	Primary Contributor
4289	Procedures for Isolating and Characterizing the Function of Non-human Primate Islets	Mar 15, 2012
4292	Analysis of NHP islets	Mar 15, 2012
4304	Procedures for Procuring and Shipping NHP Fetal Pancreatic Fragments	Mar 16, 2012	Yes
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