Manami Hara, D.D.S., Ph.D.

Assistant Professor
The University of Chicago
Medicine

5841 S. Maryland Ave., MC1027
Chicago, IL 60637
USA

p. 773-702-3727
f. 773-834-0486
· email

Manami Hara, D.D.S., Ph.D. - Co-investigator Profile

Our laboratory is interested in the mechanisms regulating pancreatic islet structure and function during development and in pathophysiological states such as diabetes and obesity. We use large-scale image capture of the entire pancreas or tissue section and unbiased computer-assisted quantitative analyses to describe the changes in islet number, size, shape and cellular composition. We use these data and mathematical modeling to develop models of islet formation that can be tested experimentally.

Scientific Interests/Keywords

beta cell, islet, islet formation, pathology of the pancreas

Publication	Citation
22102895	Kilimnik G, Zhao B, Jo J, Periwal V, Witkowski P, Misawa R, Hara M Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes. (2011) PLoS One 6: e27445 (Added 2012-03-13 16:11:08.463072)
21865948	Marek N, Krzystyniak A, Ergenc I, Cochet O, Misawa R, Wang LJ, Gołąb K, Wang X, Kilimnik G, Hara M, Kizilel S, Trzonkowski P, Millis JM, Witkowski P Coating human pancreatic islets with CD4(+)CD25(high)CD127(-) regulatory T cells as a novel approach for the local immunoprotection. (2011) Ann Surg 254: 512-8; discussion 518-9 (Added 2012-03-13 16:11:53.454539)
21806924	Jo J, Kilimnik G, Kim A, Guo C, Periwal V, Hara M Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures. (2011) Biophys J 101: 565-74 (Added 2012-03-13 16:26:40.832964)
21403638	Kim A, Kilimnik G, Guo C, Sung J, Jo J, Periwal V, Witkowski P, Dilorio P, Hara M Computer-assisted large-scale visualization and quantification of pancreatic islet mass, size distribution and architecture. (2011) J Vis Exp : (Added 2012-03-13 16:12:12.298942)
21278490	Stein J, Milewski WM, Hara M, Steiner DF, Dey A GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). () Islets 3: 21-34 (Added 2012-03-13 16:12:37.284117)
20657753	Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration. () Islets 2: 149-55 (Added 2012-03-13 16:13:00.990607)
20657742	Steiner DJ, Kim A, Miller K, Hara M Pancreatic islet plasticity: interspecies comparison of islet architecture and composition. () Islets 2: 135-45 (Added 2012-03-13 16:14:04.124763)
20606719	Kim A, Miller K, Jo J, Kilimnik G, Wojcik P, Hara M Islet architecture: A comparative study. () Islets 1: 129-36 (Added 2012-03-13 16:14:23.94392)
20548281	Kim A, Kilimnik G, Hara M In situ quantification of pancreatic beta-cell mass in mice. (2010) J Vis Exp : (Added 2012-03-13 16:15:29.4276)
19893748	Miller K, Kim A, Kilimnik G, Jo J, Moka U, Periwal V, Hara M Islet formation during the neonatal development in mice. (2009) PLoS One 4: e7739 (Added 2012-03-13 16:15:47.487837)
19808908	Kilimnik G, Kim A, Jo J, Miller K, Hara M Quantification of pancreatic islet distribution in situ in mice. (2009) Am J Physiol Endocrinol Metab 297: E1331-8 (Added 2012-03-13 16:16:47.537293)
19595468	Kharouta M, Miller K, Kim A, Wojcik P, Kilimnik G, Dey A, Steiner DF, Hara M No mantle formation in rodent islets -- the prototype of islet revisited. (2009) Diabetes Res Clin Pract 85: 252-7 (Added 2012-03-13 16:17:09.446862)

Resource ID	Name	Contributed on	Primary Contributor
188	MIP-GFP	Mar 7, 2006	Yes
1 completed resources viewable