Markus Grompe, M.D.

Professor/Director
Oregon Health & Science University
Pape Family Pediatric Research Institute

3181 SW Sam Jackson Park Rd., L321
Portland, OR 97239-3098
USA

p. 503-494-6888
f. 503-418-5044
· email
· website

Markus Grompe, M.D. - Investigator Profile

Dr. Grompe received his medical degree (Dr. med.) in 1982 at the University of Ulm Medical School in Germany. From 1984-1987 Dr. Grompe was trained in Pediatrics at Oregon Health Sciences University in Portland, Oregon, USA and then moved to Baylor College of Medicine in Houston, Texas. There he was a fellow sponsored by the Pediatric Scientist Training Program in the Institute for Molecular Genetics from 1987-1991 and worked on gene therapy for inherited diseases, particularly metabolic liver disorders.

In 1991, Dr. Grompe joined the faculty at Oregon Health & Science University and he is currently Professor in the Departments of Pediatrics and Molecular and Medical Genetics. He is a recipient of the E. Mead Johnson award for pediatric research (2002) and the Merit Award of the Fanconi Anemia Research Foundation (2002). He is involved in the clinical care of patients with genetic diseases as well as scientific investigation. In 2004 he became the first director of the newly founded Oregon Stem Cell Center. Since 2008 he is the holder of the Ray Hickey Chair and the Director of the Papé Family Pediatric Research Institute.

His current research interests include hepatic stem cell biology, beta-cell replacement therapy and Fanconi''s Anemia.

Scientific Interests/Keywords

metabolic liver diseases, molecular genetics of Fanconi Anemia, hepatic and pancreatic stem cells

Publication	Citation
20861837	Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, Lenzi ML, Olson SB, Finegold MJ, Grompe M The ploidy conveyor of mature hepatocytes as a source of genetic variation. (2010) Nature 467: 707-10 (Added 2011-01-27 11:27:31.629317)
19522011	Gadue P, Gouon-Evans V, Cheng X, Wandzioch E, Zaret KS, Grompe M, Streeter PR, Keller GM Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. (2009) Stem Cells 27: 2103-13 (Added 2011-03-15 14:49:52.137237)
19470389	Duncan AW, Dorrell C, Grompe M Stem cells and liver regeneration. (2009) Gastroenterology 137: 466-81 (Added 2011-12-06 15:03:29.26254)
19383399	Dorrell C, Abraham SL, Lanxon-Cookson KM, Canaday PS, Streeter PR, Grompe M Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. (2008) Stem Cell Res 1: 183-94 (Added 2011-12-06 15:02:30.596077)
19383389	Erker L, Grompe M Signaling networks in hepatic oval cell activation. (2007) Stem Cell Res 1: 90-102 (Added 2010-06-30 19:14:25.414444)
19229314	Duncan AW, Hickey RD, Paulk NK, Culberson AJ, Olson SB, Finegold MJ, Grompe M Ploidy reductions in murine fusion-derived hepatocytes. (2009) PLoS Genet 5: e1000385 (Added 2010-06-30 19:12:32.680658)
19056973	Zaret KS, Grompe M Generation and regeneration of cells of the liver and pancreas. (2008) Science 322: 1490-4 (Added 2010-06-30 19:12:32.687566)
18726953	Dorrell C, Erker L, Lanxon-Cookson KM, Abraham SL, Victoroff T, Ro S, Canaday PS, Streeter PR, Grompe M Surface markers for the murine oval cell response. (2008) Hepatology 48: 1282-91 (Added 2011-12-06 15:03:33.029965)
18598944	Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis. (2008) Cancer Cell 14: 59-67 (Added 2010-06-30 19:14:25.407867)
17664939	Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. (2007) Nat Biotechnol 25: 903-10 (Added 2011-12-06 15:03:38.626869)
16763912	Grompe M Principles of therapeutic liver repopulation. (2006) J Inherit Metab Dis 29: 421-5 (Added 2010-06-30 19:14:25.421537)
16401474	Vogel A, Aslan JE, Willenbring H, Klein C, Finegold M, Mount H, Thomas G, Grompe M Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases. (2006) Gastroenterology 130: 104-19 (Added 2006-08-23 12:38:16)
16216560	Held PK, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, Olson S, Fleming WH, Finegold M, Grompe M In vivo genetic selection of renal proximal tubules. (2006) Mol Ther 13: 49-58 (Added 2006-08-23 12:39:26)
16050248	Grompe M Bone marrow-derived hepatocytes. (2005) Novartis Found Symp 265: 20-7; discussion 28-34, 92-7 (Added 2005-08-08 17:42:40)
15940647	Grompe M The origin of hepatocytes. (2005) Gastroenterology 128: 2158-60 (Added 2005-08-15 13:54:21)
15731255	Nakai H, Wu X, Fuess S, Storm TA, Munroe D, Montini E, Burgess SM, Grompe M, Kay MA Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. (2005) J Virol 79: 3606-14 (Added 2010-08-16 12:01:27.353802)
15727936	Held PK, Olivares EC, Aguilar CP, Finegold M, Calos MP, Grompe M In vivo correction of murine hereditary tyrosinemia type I by phiC31 (2005) Mol Ther 11: 399-408 (Added 2005-08-15 13:54:55)
15665282	Houghtaling S, Granville L, Akkari Y, Torimaru Y, Olson S, Finegold M, Grompe M Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation (2005) Cancer Res 65: 85-91 (Added 2005-08-15 13:55:10)
15195088	Willenbring H, Bailey AS, Foster M, Akkari Y, Dorrell C, Olson S, Finegold M, Fleming WH, Grompe M Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. (2004) Nat Med 10: 744-8 (Added 2005-08-15 13:56:06)
15093183	Gupta M, Jansen EE, Senephansiri H, Jakobs C, Snead OC, Grompe M, Gibson KM Liver-directed adenoviral gene transfer in murine succinate semialdehyde (2004) Mol Ther 9: 527-39 (Added 2005-08-15 13:56:18)
14767996	Vogel A, van Den Berg IE, Al-Dhalimy M, Groopman J, Ou CN, Ryabinina O, Iordanov MS, Finegold M, Grompe M Chronic liver disease in murine hereditary tyrosinemia type 1 induces (2004) Hepatology 39: 433-43 (Added 2005-08-15 14:34:34)
14752819	Grompe M The importance of knowing your identity: sources of confusion in stem cell (2004) Hepatology 39: 35-7 (Added 2005-08-15 14:35:04)
14722813	Grompe M The role of bone marrow stem cells in liver regeneration. (2003) Semin Liver Dis 23: 363-72 (Added 2005-08-15 14:35:15)
14649377	Willenbring H, Grompe M Embryonic versus adult stem cell pluripotency: in liver only fusion (2003) J Assist Reprod Genet 20: 393-4 (Added 2005-08-15 14:35:41)
14635103	Akaboshi S, Hogema BM, Novelletto A, Malaspina P, Salomons GS, Maropoulos GD, Jakobs C, Grompe M, Gibson KM Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) (2003) Hum Mutat 22: 442-50 (Added 2005-08-15 14:35:55)
12902545	Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M The origin and liver repopulating capacity of murine oval cells. (2003) Proc Natl Acad Sci U S A 100 Suppl 1: 11881-8 (Added 2006-08-23 12:41:27)
12665832	Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M Cell fusion is the principal source of bone-marrow-derived hepatocytes. (2003) Nature 422: 897-901 (Added 2006-08-23 12:42:03)
12490300	Grompe M Pancreatic-hepatic switches in vivo. (2003) Mech Dev 120: 99-106 (Added 2006-08-23 12:44:42)
11159194	Wang X, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. (2001) Am J Pathol 158: 571-9 (Added 2006-08-23 12:46:27)
10595942	Overturf K, Al-Dhalimy M, Finegold M, Grompe M The repopulation potential of hepatocyte populations differing in size and (1999) Am J Pathol 155: 2135-43 (Added 2005-08-15 13:43:54)
10518553	Manning K, Al-Dhalimy M, Finegold M, Grompe M In vivo suppressor mutations correct a murine model of hereditary (1999) Proc Natl Acad Sci U S A 96: 11928-33 (Added 2005-08-15 13:43:38)

Resource ID	Name	Contributed on	Primary Contributor
326	Monoclonal Human Pancreatic endocrine cells raised in Mouse	Jul 14, 2006	Yes
327	Monoclonal Human Pancreatic endocrine cells raised in Mouse	Jul 14, 2006	Yes
328	Monoclonal Human Pancreatic endocrine cells raised in Mouse	Jul 14, 2006	Yes
329	Monoclonal Human Pancreatic endocrine cells raised in Mouse	Jul 14, 2006	Yes
330	Monoclonal Human Pancreatic endocrine cells raised in Mouse	Jul 14, 2006	Yes
337	Monoclonal Human Pancreatic duct cells raised in Mouse	Oct 17, 2007	Yes
338	Monoclonal Human Pancreatic duct cells raised in Mouse	Oct 17, 2007	Yes
339	Monoclonal Human Pancreatic exocrine cells raised in Mouse	Oct 17, 2007	Yes
340	Monoclonal Human Pancreatic exocrine cells raised in Mouse	Oct 18, 2007	Yes
341	Monoclonal Human Pancreatic endocrine cells raised in Mouse	Oct 18, 2007	Yes
342	Monoclonal Human Alpha cells raised in Mouse	Oct 18, 2007	Yes
343	Monoclonal Human Alpha cells raised in Mouse	Oct 18, 2007	Yes
344	Monoclonal Mouse Mo ES-Derived Definitive Endoderm raised in Rat	Dec 19, 2007	Yes
345	Monoclonal Mouse Mo ES-Derived Definitive Endoderm raised in Rat	Dec 19, 2007	Yes
901	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
903	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
904	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
905	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
906	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
907	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
908	Monoclonal Mouse Mo ES-Derived Early Endoderm raised in Rat	Feb 10, 2009	Yes
921	Monoclonal Human Hu ES-Derived Early Endoderm raised in Mouse	Feb 10, 2009	Yes
922	Monoclonal Human Hu ES-Derived Early Endoderm raised in Mouse	Feb 10, 2009	Yes
941	Monoclonal Human Hu ES-Derived Early Endoderm raised in Mouse	Feb 10, 2009	Yes
942	Monoclonal Mouse Pancreatic duct cells raised in Rat	Feb 10, 2009	Yes
943	Monoclonal Mouse Pancreatic duct and acinar cells raised in Rat	Feb 10, 2009	Yes
945	Monoclonal Mouse Endothelial cells raised in Rat	Feb 11, 2009	Yes
1581	Isolation of different types of adult human pancreatic cells	Jun 5, 2009	Yes
1781	Cell surface markers that distinguish human beta cells and alpha cells	Aug 11, 2009	Yes
3162	Differential expression of sorted Alpha and Beta cells	May 26, 2010	Yes
3182	Differential expression of representative sorted pancreatic cells	Jun 2, 2010	Yes
4279	Tissue culture protocol for expansion of human gallbladder cells	Mar 12, 2012	Yes
4280	Isolation of Single Human Beta Cells - Identifying Somatic Mutations	Mar 12, 2012
4281	Estimation of Depth of Somatic Mutations in Human Beta Cells.	Mar 12, 2012
4284	Identification of the Reprogramming Target Cells in Murine Gall Bladder Cells	Mar 13, 2012	Yes
4285	Tissue Culture Protocol for Expansion of Murine Gallbladder Cells	Mar 13, 2012	Yes
4337	Reprogramming of mouse gall bladder cells into pancreatic beta cells	Apr 24, 2012	Yes
4532	Baseline gene expression profile of human extrahepatic biliary cells/biliospheres in vitro	Aug 7, 2012	Yes
4585	Baseline miRNA expression profile of human extrahepatic biliary cells/biliospheres in vitro	Apr 16, 2013	Yes
39 completed resources viewable