Maike Sander, M.D.

Professor
University of California at San Diego
Department of Pediatrics and Cellular & Molecular Medicine

9500 Gilman Drive MC0695
la Jolla, CA 92093-0695
USA

p. 858-246-0843
f. 858-246-0162
· email
· website

Maike Sander, M.D. - Investigator Profile

Our laboratory aims to understand the molecular mechanisms by which several classes of transcription factors coordinate development of the mammalian pancreas. During pancreas development, a common endocrine precursor cell gives rise to all four endocrine cell types, each of which can be readily distinguished by the production of a characteristic hormone. The apparent simplicity of the system makes the endocrine pancreas an ideal system to explore the roles of specific families of transcription factors in the cell specification and differentiation. Our investigation of this system aims to understand the roles of transcription factors in coordinating the appearance of specific cell phenotypes, and to gain insight into the molecular mechanisms of synergistic activation and repression of gene expression. To achieve this goal we combine genetic, molecular, and genomic approaches, using the mouse as a model system.

Scientific Interests/Keywords

Genetic control of pancreatic cell differentiation, using mouse and human embryonic stem cells as model systems.

Publication	Citation
23318056	Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. (2013) Cell Stem Cell 12: 224-37 (Added 2013-02-26 08:50:01.329474)
23251699	van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. (2012) PLoS One 7: e52181 (Added 2013-04-20 17:06:27.944877)
23201164	Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. (2012) Cancer Cell 22: 737-50 (Added 2013-03-14 16:22:40.388779)
22874919	Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. (2012) Development 139: 3363-72 (Added 2013-01-23 12:28:26.271884)
22675211	Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin-Botton A, Sander M A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. (2012) Development 139: 2488-99 (Added 2013-01-23 12:28:09.867122)
21964593	Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance. (2011) Mol Endocrinol 25: 1904-14 (Added 2013-01-23 12:30:42.61606)
21558806	Kopp JL, Dubois CL, Hao E, Thorel F, Herrera PL, Sander M Progenitor cell domains in the developing and adult pancreas. (2011) Cell Cycle 10: 1921-7 (Added 2012-01-06 04:08:55.378012)
21266405	Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. (2011) Development 138: 653-65 (Added 2011-06-04 22:55:24.439309)
20627083	Schaffer AE, Freude KK, Nelson SB, Sander M Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. (2010) Dev Cell 18: 1022-9 (Added 2010-09-02 16:10:45.995414)
19487660	Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. (2009) Proc Natl Acad Sci U S A 106: 9715-20 (Added 2010-09-02 16:12:04.015023)
18723011	Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. (2008) Dev Biol 323: 19-30 (Added 2009-03-11 20:36:47)
18452912	Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. (2008) Dev Biol 318: 224-35 (Added 2009-03-11 20:37:27)
17537793	Nelson SB, Schaffer AE, Sander M The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. (2007) Development 134: 2491-500 (Added 2009-03-11 20:39:01)
17267606	Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M From the Cover: SOX9 is required for maintenance of the pancreatic progenitor cell pool. (2007) Proc Natl Acad Sci U S A 104: 1865-70 (Added 2007-02-19 18:54:58)
16297379	Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P Endodermal expression of Nkx6 genes depends differentially on Pdx1. (2005) Dev Biol 288: 487-501 (Added 2007-02-19 18:54:41)
15944193	Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M NKX6 transcription factor activity is required for (alpha)and (2005) Development 132: 3139-49 (Added 2005-09-07 11:42:38)
15928328	Nelson SB, Janiesch C, Sander M Expression of Nkx6 genes in the hindbrain and gut of the developing mouse. (2005) J Histochem Cytochem 53: 787-90 (Added 2005-09-07 11:42:57)
15629701	Cai J, Qi Y, Hu X, Tan M, Liu Z, Zhang J, Li Q, Sander M, Qiu M Generation of oligodendrocyte precursor cells from mouse dorsal spinal (2005) Neuron 45: 41-53 (Added 2005-09-07 11:58:46)
15297605	Mellitzer G, Martin M, Sidhoum-Jenny M, Orvain C, Barths J, Seymour PA, Sander M, Gradwohl G Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent (2004) Mol Endocrinol 18: 2765-76 (Added 2005-09-07 11:46:07)
14973194	Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R The MafA transcription factor appears to be responsible for (2004) Proc Natl Acad Sci U S A 101: 2930-3 (Added 2005-09-07 11:44:15)

Resource ID	Name	Contributed on	Primary Contributor
205	Nkx6.1^DsRed2/+	Oct 15, 2007	Yes
1342	Nkx6.1^flox	Mar 26, 2009	Yes
4029	Rosa26^Sox9.Cherry	Sep 17, 2010	Yes
4030	Rosa26^{(TetO.Sox9)Msan}	Sep 17, 2010	Yes
4031	Rosa26^TetO.NRSF	Sep 20, 2010	Yes
4122	FACS of Human Islet Cell Types	Aug 3, 2011	Yes
4136	Chemical Differentiation of Human Pluripotent Stem Cells to Definitive Endoderm Using a Potent Small Molecule Inhibitor of GSK-3	Sep 30, 2011
4137	Fibronectin and Vitronectin Improve Differentiation of Human Pluripotent Stem Cells to Definitive Endoderm	Sep 30, 2011
4140	Sander monolayer CyT49 differentiation protocol	Nov 4, 2011	Yes
4152	Rosa26^{(TetO.NRSF)Msan}	Nov 28, 2011	Yes
4178	Transcriptional and epigenetic profiling of the progression of hESCs to beta cells	Jan 17, 2012	Yes
4544	Ferrer lncRNA manuscript - confidential	Sep 26, 2012
4564	ChIP-Seq analysis of enhancer related histone modifications during hESC differentiation towards pancreatic endoderm.	Feb 26, 2013	Yes
13 completed resources viewable