Chris Wright, D. Phil.

Professor/Director
Vanderbilt University
Cell & Developmental Biology/Program in Developmental Biology

3140A MRB III VUMC, 465 21st Avenue South
Nashville, TN 37232-8240
USA

p. 615-343-8256
f. 615-322-1917
· email
· website

Chris Wright, D. Phil. - Investigator Profile

We are studying secreted intercellular signaling molecules or transcription factors that dictate cell fates in different parts of the embryo. These include the TGF -superfamily members nodal and BMP4 (and their transmembrane kinase receptors), and homeodomain-containing transcription factors, which are expressed according to the type of extracellular signals received by a cell. Our main model systems are the frog and mouse. Frog embryos can be microinjected with plasmids, mRNA, proteins and antibodies, and the large number of embryos available allows biochemical studies. In contrast, the mouse allows genetic analysis of function. We can transgenically misexpress proteins, or genes can be inactivated or mutated by gene recombination in ES cells. The latter can be done globally, or tissue-specifically, by inactivation techniques that can be targeted to chosen tissues and switched on/off as required.

Scientific Interests/Keywords

Molecular embryology, vertebrate embryogenesis, transcription factors, intercellular signaling, stem cells

Publication	Citation
21852533	Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. (2011) Genes Dev 25: 1680-5 (Added 2012-01-06 04:09:15.567516)
21539888	Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. (2011) Mol Cell Endocrinol 339: 144-50 (Added 2013-03-14 16:24:18.452249)
21337462	Pan FC, Wright C Pancreas organogenesis: from bud to plexus to gland. (2011) Dev Dyn 240: 530-65 (Added 2011-03-31 10:35:47.036223)
20025861	Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. (2010) Dev Biol : (Added 2010-01-07 13:47:51.218523)
19804761	Betley JN, Wright CV, Kawaguchi Y, Erdélyi F, Szabó G, Jessell TM, Kaltschmidt JA Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. (2009) Cell 139: 161-74 (Added 2010-01-07 13:47:51.256158)
19759004	Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. (2009) J Biol Chem 284: 31236-48 (Added 2010-01-07 13:47:51.260206)
19520072	Skuntz S, Mankoo B, Nguyen MT, Hustert E, Nakayama A, Tournier-Lasserve E, Wright CV, Pachnis V, Bharti K, Arnheiter H Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. (2009) Dev Biol 332: 383-95 (Added 2010-01-07 13:47:51.264198)
18654634	Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B, Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK, Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. (2008) PLoS Genet 4: e1000137 (Added 2009-03-18 15:07:35)
18591390	Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice. (2008) Diabetes 57: 2421-31 (Added 2009-03-18 15:07:52)
18294628	Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. (2008) Dev Biol 316: 74-86 (Added 2010-12-20 14:32:29.029104)
18155690	Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. (2008) Dev Biol 314: 406-17 (Added 2009-03-18 15:08:17)
17761679	Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. (2007) J Biol Chem 282: 32084-92 (Added 2011-04-19 12:44:37.68382)
17584861	Westmoreland JJ, Takahashi S, Wright CV Xenopus Lefty requires proprotein cleavage but not N-linked glycosylation to inhibit nodal signaling. (2007) Dev Dyn 236: 2050-61 (Added 2010-01-07 13:48:04.151012)
17403901	Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. (2007) Mol Cell Biol 27: 4093-104 (Added 2011-08-22 14:45:13.137959)
17372229	Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok M, Lewis BC Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. (2007) Proc Natl Acad Sci U S A 104: 5103-8 (Added 2009-03-18 15:08:57)
17360405	Pascual M, Abasolo I, Mingorance-Le Meur A, Martinez A, Del Rio JA, Wright CV, Real FX, Soriano E Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. (2007) Proc Natl Acad Sci U S A 104: 5193-8 (Added 2009-03-18 15:09:27)
17320068	Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. (2007) Dev Biol 304: 786-99 (Added 2009-03-18 15:09:40)
17114585	Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. (2006) Genes Dev 20: 3147-60 (Added 2009-03-18 15:09:56)
17075007	Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. (2006) Development 133: 4439-50 (Added 2009-03-18 15:10:17)
16962573	Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. (2006) Dev Biol 298: 616-31 (Added 2011-08-22 14:45:20.33664)
16959238	Ohi Y, Wright CV Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. (2007) Dev Biol 301: 447-63 (Added 2010-01-07 13:48:04.160275)
16791846	Takahashi S, Onuma Y, Yokota C, Westmoreland JJ, Asashima M, Wright CV Nodal-related gene Xnr5 is amplified in the Xenopus genome. (2006) Genesis 44: 309-21 (Added 2010-01-07 13:48:13.858552)
16751181	Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV, Fujitani Y Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. (2006) Genes Dev 20: 1435-40 (Added 2009-03-18 15:11:16)
16710472	Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. (2006) J Clin Invest 116: 1484-93 (Added 2009-03-18 15:11:32)
16530524	Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Kuhara T, Horiguchi M, Koizumi M, Fujimoto K, Doi R, Wright CV, Chiba T Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. (2006) Gastroenterology 130: 855-67 (Added 2009-03-18 15:11:47)
16418487	Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. (2006) Genes Dev 20: 253-66 (Added 2011-08-22 14:45:46.650688)
16407138	Ripley AN, Osler ME, Wright CV, Bader D Xbves is a regulator of epithelial movement during early Xenopus laevis development. (2006) Proc Natl Acad Sci U S A 103: 614-9 (Added 2010-01-07 13:48:13.867808)
16405884	Cha YR, Takahashi S, Wright CV Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. (2006) Dev Biol 290: 246-64 (Added 2010-01-07 13:48:13.872014)
16397208	Hruban RH, Rustgi AK, Brentnall TA, Tempero MA, Wright CV, Tuveson DA Pancreatic cancer in mice and man: the Penn Workshop 2004. (2006) Cancer Res 66: 14-7 (Added 2009-03-18 15:12:19)
16297379	Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P Endodermal expression of Nkx6 genes depends differentially on Pdx1. (2005) Dev Biol 288: 487-501 (Added 2009-03-18 15:12:31)
16291784	Glasgow SM, Henke RM, Macdonald RJ, Wright CV, Johnson JE Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. (2005) Development 132: 5461-9 (Added 2009-03-18 15:12:41)
16127715	Chea HK, Wright CV, Swalla BJ Nodal signaling and the evolution of deuterostome gastrulation. (2005) Dev Dyn 234: 269-78 (Added 2010-01-07 13:48:21.289954)
16039563	Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CV, Kawaguchi Y, Nakao K, Nabeshima Y Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005) Neuron 47: 201-13 (Added 2009-03-18 15:13:06)
16020518	Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ Jr, Wright CV, Stoffers DA, Leach SD Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. (2005) Development 132: 3767-76 (Added 2009-03-18 15:13:16)
15986486	Zhang H, Fujitani Y, Wright CV, Gannon M Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. (2005) Genesis 42: 210-7 (Added 2011-08-22 14:45:49.301067)
15905132	Mead PE, Parganas E, Ohtsuka S, Morishita K, Gamer L, Kuliyev E, Wright CV, Ihle JN Evi-1 expression in Xenopus. (2005) Gene Expr Patterns 5: 601-8 (Added 2010-01-07 13:48:21.297634)
15887112	Nomura S, Settle SH, Leys CM, Means AL, Peek RM Jr, Leach SD, Wright CV, Coffey RJ, Goldenring JR Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFalpha overexpression. (2005) Gastroenterology 128: 1292-305 (Added 2009-03-18 15:13:39)
15828001	Means AL, Chytil A, Moses HL, Coffey RJ Jr, Wright CV, Taketo MM, Grady WM Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. (2005) Genesis 42: 23-7 (Added 2009-03-18 15:13:51)
15562255	Brissova M, Blaha M, Spear C, Nicholson W, Radhika A, Shiota M, Charron MJ, Wright CV, Powers AC Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. (2005) Am J Physiol Endocrinol Metab 288: E707-14 (Added 2009-03-18 15:14:02)
15486225	Jepeal LI, Fujitani Y, Boylan MO, Wilson CN, Wright CV, Wolfe MM Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. (2005) Endocrinology 146: 383-91 (Added 2009-03-18 15:14:14)
15335681	Wright CV Hox genes and the hindbrain. (1993) Curr Biol 3: 618-21 (Added 2010-01-07 13:49:48.98434)
14706336	Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. (2003) Cancer Cell 4: 437-50 (Added 2009-03-18 15:14:25)
12925591	Mankoo BS, Skuntz S, Harrigan I, Grigorieva E, Candia A, Wright CV, Arnheiter H, Pachnis V The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. (2003) Development 130: 4655-64 (Added 2010-01-07 13:48:29.129161)
12869553	Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R, Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. (2003) J Biol Chem 278: 43691-8 (Added 2009-03-18 15:14:40)
12671899	Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC Jr, Wright CV, Coffey RJ Jr, Leach SD Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. (2003) Gastroenterology 124: 1020-36 (Added 2009-03-18 15:14:54)
12488434	Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. (2002) J Clin Invest 110: 1839-47 (Added 2009-03-18 15:15:06)
12353488	Wright CV, Halpern ME Specification of left-right asymmetry. (2002) Results Probl Cell Differ 40: 96-116 (Added 2010-01-07 13:48:29.138053)
12219087	Nakae J, Biggs WH 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. (2002) Nat Genet 32: 245-53 (Added 2009-03-18 15:15:23)
12185368	Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. (2002) Nat Genet 32: 128-34 (Added 2011-08-22 14:45:59.153627)
12052878	Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. (2002) Mol Cell Biol 22: 4702-13 (Added 2009-03-18 15:15:51)
11994408	Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF Pdx1 restores beta cell function in Irs2 knockout mice. (2002) J Clin Invest 109: 1193-201 (Added 2005-04-13 13:00:53)
11904435	Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M Profound defects in pancreatic beta-cell function in mice with combined (2002) Proc Natl Acad Sci U S A 99: 3818-23 (Added 2005-04-13 13:00:51)
11857781	Chytil A, Magnuson MA, Wright CV, Moses HL Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. (2002) Genesis 32: 73-5 (Added 2005-04-13 13:00:45)
11784003	Gannon M, Gamer LW, Wright CV Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. (2001) Dev Biol 238: 185-201 (Added 2011-08-22 14:46:06.159955)
11781323	Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. (2002) J Biol Chem 277: 11225-32 (Added 2011-08-22 14:46:08.892903)
11702778	Wright CV Mechanisms of left-right asymmetry: what's right and what's left? (2001) Dev Cell 1: 179-86 (Added 2010-01-07 13:48:43.567273)
11566861	Erter CE, Wilm TP, Basler N, Wright CV, Solnica-Krezel L Wnt8 is required in lateral mesendodermal precursors for neural (2001) Development 128: 3571-83 (Added 2005-04-13 13:00:43)
11289043	Hui H, Wright C, Perfetti R Glucagon-like peptide 1 induces differentiation of islet duodenal (2001) Diabetes 50: 785-96 (Added 2005-04-13 13:00:25)
11158595	Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. (2001) Proc Natl Acad Sci U S A 98: 1065-70 (Added 2011-08-22 14:46:15.756002)
11124801	Gonzalez EM, Fekany-Lee K, Carmany-Rampey A, Erter C, Topczewski J, Wright CV, Solnica-Krezel L Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino. (2000) Genes Dev 14: 3087-92 (Added 2010-01-07 13:48:43.574889)
10851133	Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. (2000) Development 127: 2883-95 (Added 2011-08-22 14:46:17.265103)
10804190	Osada SI, Saijoh Y, Frisch A, Yeo CY, Adachi H, Watanabe M, Whitman M, Hamada H, Wright CV Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1. (2000) Development 127: 2503-14 (Added 2010-01-07 13:48:43.583607)
10686611	Gannon M, Herrera PL, Wright CV Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. (2000) Genesis 26: 143-4 (Added 2011-08-22 14:46:19.650816)
10686610	Gannon M, Shiota C, Postic C, Wright CV, Magnuson M Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. (2000) Genesis 26: 139-42 (Added 2011-08-22 14:46:21.699179)
10667793	Thisse B, Wright CV, Thisse C Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. (2000) Nature 403: 425-8 (Added 2010-01-07 13:49:00.223392)
10662644	Cheng AM, Thisse B, Thisse C, Wright CV The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. (2000) Development 127: 1049-61 (Added 2010-01-07 13:49:00.227965)
10652343	Gerrish K, Gannon M, Shih D, Henderson E, Stoffel M, Wright CV, Stein R Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. (2000) J Biol Chem 275: 3485-92 (Added 2010-01-07 13:49:00.232528)
10579983	Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. (1999) Gastroenterology 117: 1416-26 (Added 2011-08-22 14:46:26.670454)
10403250	Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V Mox2 is a component of the genetic hierarchy controlling limb muscle (1999) Nature 400: 69-73 (Added 2005-04-13 13:08:25)
10375512	Osada SI, Wright CV Xenopus nodal-related signaling is essential for mesendodermal patterning (1999) Development 126: 3229-40 (Added 2005-04-13 13:08:22)
10049358	Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL Bmp4 is required for the generation of primordial germ cells in the mouse embryo. (1999) Genes Dev 13: 424-36 (Added 2010-01-07 13:49:00.244838)
9882476	Erter CE, Solnica-Krezel L, Wright CV Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. (1998) Dev Biol 204: 361-72 (Added 2010-01-07 13:49:00.249401)
9744278	Sampath K, Rubinstein AL, Cheng AM, Liang JO, Fekany K, Solnica-Krezel L, Korzh V, Halpern ME, Wright CV Induction of the zebrafish ventral brain and floorplate requires (1998) Nature 395: 185-9 (Added 2005-04-13 13:08:19)
9710595	Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM, Wright CV, MacDonald RJ An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). (1998) Mol Cell Biol 18: 5109-20 (Added 2010-01-07 13:49:18.057897)
9671733	Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. (1998) Proc Natl Acad Sci U S A 95: 8654-9 (Added 2012-11-08 15:38:02.431141)
9572111	Wright CV Lateral asymmetry in multicellular organisms. (1998) Semin Cell Dev Biol 9: 31-3 (Added 2010-01-07 13:49:18.068391)
9425138	Frisch A, Wright CV XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues. (1998) Development 125: 431-42 (Added 2010-01-07 13:49:18.072937)
9315659	Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. (1997) Mol Cell Biol 17: 6002-13 (Added 2011-08-22 14:46:27.922817)
9310324	Sampath K, Cheng AM, Frisch A, Wright CV Functional differences among Xenopus nodal-related genes in left-right axis determination. (1997) Development 124: 3293-302 (Added 2010-01-07 13:49:18.082592)
9199333	Peshavaria M, Henderson E, Sharma A, Wright CV, Stein R Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. (1997) Mol Cell Biol 17: 3987-96 (Added 2010-01-07 13:49:18.08746)
9075740	Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. (1997) Endocrinology 138: 1750-62 (Added 2010-01-07 13:49:18.092135)
9032023	Candia AF, Wright CV Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. (1996) Int J Dev Biol 40: 1179-84 (Added 2010-01-07 13:49:18.096835)
8631275	Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. (1996) Development 122: 983-95 (Added 2012-11-08 15:38:22.324709)
8625841	Jones CM, Dale L, Hogan BL, Wright CV, Smith JC Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause (1996) Development 122: 1545-54 (Added 2005-04-13 13:08:14)
8610013	Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn MR Conserved left-right asymmetry of nodal expression and alterations in (1996) Nature 381: 158-61 (Added 2005-04-13 13:08:12)
8582278	Jones CM, Kuehn MR, Hogan BL, Smith JC, Wright CV Nodal-related signals induce axial mesoderm and dorsalize mesoderm during (1995) Development 121: 3651-62 (Added 2005-04-13 12:50:54)
8421061	Wall NA, Blessing M, Wright CV, Hogan BL Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). (1993) J Cell Biol 120: 493-502 (Added 2010-01-07 13:50:06.593912)
8119124	Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. (1994) Development 120: 165-75 (Added 2010-01-07 13:49:48.969277)
7935494	Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CV, Stein R XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. (1994) Mol Endocrinol 8: 806-16 (Added 2010-01-07 13:49:48.964227)
7909944	Candia AF, Kovalik JP, Wright CV Amino acid sequence of Mox-2 and comparison to its Xenopus and rat homologs. (1993) Nucleic Acids Res 21: 4982 (Added 2010-01-07 13:49:48.979337)
7904966	Barnes JD, Crosby JL, Jones CM, Wright CV, Hogan BL Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. (1994) Dev Biol 161: 168-78 (Added 2010-01-07 13:49:48.974304)
7902125	Gamer LW, Wright CV Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. (1993) Mech Dev 43: 71-81 (Added 2010-01-07 13:49:48.989419)
7867492	Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. (1995) Development 121: 11-8 (Added 2010-01-07 13:49:48.9517)
7813784	Pierceall WE, Reale MA, Candia AF, Wright CV, Cho KR, Fearon ER Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. (1994) Dev Biol 166: 654-65 (Added 2010-01-07 13:49:48.956766)
7768180	Toyama R, O'Connell ML, Wright CV, Kuehn MR, Dawid IB Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. (1995) Development 121: 383-91 (Added 2010-01-07 13:49:32.594938)
7734393	Conlon FL, Wright CV, Robertson EJ Effects of the TWis mutation on notochord formation and mesodermal patterning. (1995) Mech Dev 49: 201-9 (Added 2010-01-07 13:49:48.945455)
7642098	Zhang X, Wright CV, Hanks SK Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development. (1995) Gene 160: 219-22 (Added 2010-01-07 13:49:32.577992)
7590740	Stoffel M, Stein R, Wright CV, Espinosa R, Le Beau MM, Bell GI Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1. (1995) Genomics 28: 125-6 (Added 2010-01-07 13:49:32.582869)
7577672	Candia AF, Wright CV The expression pattern of Xenopus Mox-2 implies a role in initial mesodermal differentiation. (1995) Mech Dev 52: 27-36 (Added 2010-01-07 13:49:32.587742)
7568086	Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, Stein R Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. (1995) Proc Natl Acad Sci U S A 92: 9127-31 (Added 2010-01-07 13:49:32.565482)
7556900	Gamer LW, Wright CV Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8. (1995) Dev Biol 171: 240-51 (Added 2010-01-07 13:49:32.573067)
6641722	Wright CV, Wright SC, Knowland J Partial purification of estradiol receptor from Xenopus laevis liver and levels of receptor in relation to estradiol concentration. (1983) EMBO J 2: 973-7 (Added 2010-01-07 13:50:39.531835)
6592586	Knowland J, Theulaz I, Wright CV, Wahli W Injection of partially purified estrogen receptor protein from Xenopus liver nuclei into oocytes activates the silent vitellogenin locus. (1984) Proc Natl Acad Sci U S A 81: 5777-81 (Added 2010-01-07 13:50:39.526168)
2908262	De Robertis EM, Burglin TR, Fritz A, Oliver G, Cho K, Wright CV Sequence conservations in vertebrate homeo-box mRNAs. (1988) Arch Biol Med Exp (Santiago) 21: 443-7 (Added 2010-01-07 13:50:22.341076)
2904837	Oliver G, Wright CV, Hardwicke J, De Robertis EM A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos. (1988) Cell 55: 1017-24 (Added 2010-01-07 13:50:22.33555)
2902559	Fritz AF, Martin G, Wright CV, De Robertis EM Site-specific inversions in repeated Xenopus laevis homeobox gene 2 sequences. (1988) Nucleic Acids Res 16: 9058 (Added 2010-01-07 13:50:39.499027)
2901347	Cho KW, Goetz J, Wright CV, Fritz A, Hardwicke J, De Robertis EM Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. (1988) EMBO J 7: 2139-49 (Added 2010-01-07 13:50:39.505981)
2894983	Wright CV, Cho KW, Fritz A, Bürglin TR, De Robertis EM A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts. (1987) EMBO J 6: 4083-94 (Added 2010-01-07 13:50:39.51749)
2892138	Bürglin TR, Wright CV, De Robertis EM Translational control in homoeobox mRNAs? (1987) Nature 330: 701-2 (Added 2010-01-07 13:50:39.511786)
2574662	Wright CV, Schnegelsberg P, De Robertis EM XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. (1989) Development 105: 787-94 (Added 2010-01-07 13:50:22.318972)
2565051	Wright CV, Cho KW, Oliver G, De Robertis EM Vertebrate homeodomain proteins: families of region-specific transcription factors. (1989) Trends Biochem Sci 14: 52-6 (Added 2010-01-07 13:50:22.324532)
2564812	De Robertis EM, Oliver G, Wright CV Determination of axial polarity in the vertebrate embryo: homeodomain proteins and homeogenetic induction. (1989) Cell 57: 189-91 (Added 2010-01-07 13:50:22.313502)
2563247	Fritz AF, Cho KW, Wright CV, Jegalian BG, De Robertis EM Duplicated homeobox genes in Xenopus. (1989) Dev Biol 131: 584-8 (Added 2010-01-07 13:50:22.330027)
2477158	Wright CV, Cho KW, Hardwicke J, Collins RH, De Robertis EM Interference with function of a homeobox gene in Xenopus embryos produces (1989) Cell 59: 81-93 (Added 2005-04-13 13:08:17)
2460338	Oliver G, Wright CV, Hardwicke J, De Robertis EM Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos. (1988) EMBO J 7: 3199-209 (Added 2010-01-07 13:50:22.346588)
2347307	Cridland NA, Wright CV, McKenzie EA, Knowland J Selective photochemical treatment of oestrogen receptor in a Xenopus liver extract destroys hormone binding and transcriptional activation but not DNA binding. (1990) EMBO J 9: 1859-66 (Added 2010-01-07 13:50:06.640624)
1976504	Wright CV, Morita EA, Wilkin DJ, De Robertis EM The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons. (1990) Development 109: 225-34 (Added 2010-01-07 13:50:22.305505)
1976086	Molven A, Wright CV, Bremiller R, De Robertis EM, Kimmel CB Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan. (1990) Development 109: 279-88 (Added 2010-01-07 13:50:22.297625)
1973846	De Robertis EM, Oliver G, Wright CV Homeobox genes and the vertebrate body plan. (1990) Sci Am 263: 46-52 (Added 2010-01-07 13:50:06.635294)
1687652	Wright CV Vertebrate homeobox genes. (1991) Curr Opin Cell Biol 3: 976-82 (Added 2010-01-07 13:50:06.622038)
1677215	Blumberg B, Wright CV, De Robertis EM, Cho KW Organizer-specific homeobox genes in Xenopus laevis embryos. (1991) Science 253: 194-6 (Added 2005-04-13 12:50:51)
1672833	Cho KW, Morita EA, Wright CV, De Robertis EM Overexpression of a homeodomain protein confers axis-forming activity to uncommitted Xenopus embryonic cells. (1991) Cell 65: 55-64 (Added 2010-01-07 13:50:06.629902)
1425343	Jones CM, Lyons KM, Lapan PM, Wright CV, Hogan BL DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. (1992) Development 115: 639-47 (Added 2010-01-07 13:50:06.611171)
1363541	Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau JH, Wright CV Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. (1992) Development 116: 1123-36 (Added 2010-01-07 13:50:06.600388)
1353982	Wall NA, Jones CM, Hogan BL, Wright CV Expression and modification of Hox 2.1 protein in mouse embryos. (1992) Mech Dev 37: 111-20 (Added 2010-01-07 13:50:06.616658)
1292571	Jegalian BG, Miller RW, Wright CV, Blum M, De Robertis EM A Hox 3.3-lacZ transgene expressed in developing limbs. (1992) Mech Dev 39: 171-80 (Added 2010-01-07 13:50:06.605948)

Resource ID	Name	Contributed on	Primary Contributor
182	pdx-CC4	Mar 7, 2006	Yes
183	pdx2E3	Mar 7, 2006	Yes
184	Ptf1a-Cre	Mar 7, 2006	Yes
242	Pdx1^deltaII	Aug 14, 2008	Yes
243	Pdx1^FloxE2	Aug 27, 2008	Yes
244	Ptf1a^LCA-CreER	Aug 14, 2008	Yes
245	Pdx1^Flox123	Aug 27, 2008	Yes
247	Pdx1^{deltaI-II-III}	Aug 27, 2008	Yes
248	Ptf1a^flox	Sep 5, 2008	Yes
4088	Pdx1^(Cre-ER)Mgn	Apr 27, 2011	Yes
4144	Pdx1^Cre.ER	Nov 21, 2011	Yes
4167	Frozen Section Staining (Indirect Immunofluorescence)	Dec 19, 2011	Yes
4330	Frozen Section Staining_Avidin/Biotin Amplification	Mar 23, 2012	Yes
4331	Frozen Section Staining_Tyramide Signal Amplification	Mar 23, 2012	Yes
4427	G17w Fetal human pancreas development (MKI67, INS, PDX1)	Apr 24, 2012
4428	G17w Fetal human pancreas development (MKI67, INS, PDX1)	Apr 24, 2012
4429	G18w Fetal human pancreas development (GCG, INS, SST)	Apr 24, 2012
4430	G18w Fetal human pancreas development (GCG, INS, SST)	Apr 24, 2012
4431	G18w Fetal human pancreas development (GCG, INS, SST)	Apr 24, 2012
4432	G18w Fetal human pancreas development (INS, GCG, SST)	Apr 24, 2012
4433	G18w Fetal human pancreas development (INS, GCG, SST)	Apr 24, 2012
4434	G18w Fetal human pancreas development (INS, GCG, SST)	Apr 24, 2012
4435	G18w Fetal human pancreas development (INS, GCG, SST)	Apr 24, 2012
4436	G18w Fetal human pancreas development (INS, GCG, SST)	Apr 24, 2012
4437	G18w Fetal human pancreas development (INS, GCG, SST)	Apr 24, 2012
4438	G18w Fetal human pancreas development (MAFB, INS, PDX1)	Apr 24, 2012
4439	G18w Fetal human pancreas development (MAFB, INS, PDX1)	Apr 24, 2012
4440	G18w Fetal human pancreas development (PDX1, INS, GCG)	Apr 24, 2012
4441	G18w Fetal human pancreas development (PDX1, INS, GCG)	Apr 24, 2012
4442	G18w Fetal human pancreas development (PDX1, INS, GCG)	Apr 24, 2012
4443	G18w Fetal human pancreas development (PDX1, INS, GCG)	Apr 24, 2012
4444	G18w Fetal human pancreas development (PDX1, INS, GCG)	Apr 24, 2012
4445	G18w Fetal human pancreas development (TUBB3, PECAM1, INS)	Apr 24, 2012
4446	G18w Fetal human pancreas development (ARX, GCG, INS)	Apr 24, 2012
4447	G18w Fetal human pancreas development (ARX, GCG, INS)	Apr 24, 2012
4448	G18w Fetal human pancreas development (NEUROG3, PAX6\|SYP, CDH1)	Apr 24, 2012
4449	G18w Fetal human pancreas development (NEUROG3, PAX6\|SYP, CDH1)	Apr 24, 2012
4450	G18w Fetal human pancreas development (NEUROG3, PAX6\|SYP, CDH1)	Apr 24, 2012
4451	G18w Fetal human pancreas development (NEUROG3, PAX6\|SYP, CDH1)	Apr 24, 2012
4452	G18w Fetal human pancreas development (NEUROG3, PAX6\|SYP, CDH1)	Apr 24, 2012
4453	G18w Fetal human pancreas development (PAX6, INS, GCG)	Apr 24, 2012
4454	G18w Fetal human pancreas development (PAX6, INS, GCG)	Apr 24, 2012
4455	G8w Fetal human pancreas development (PDX1, GCG, INS)	Apr 24, 2012
4485	G8w Fetal human pancreas development (PDX1, GCG, INS)	Apr 24, 2012
4490	G16w Fetal human pancreas development (GCG, INS, PDX1)	Jun 29, 2012
4491	G16w Fetal human pancreas development (GCG, INS, PDX1)	Jun 29, 2012
4492	G16w Fetal human pancreas development (GFAP, PECAM1, GCG\|INS\|SST)	Jun 29, 2012
4493	G16w Fetal human pancreas development (GFAP, PECAM1, GCG\|INS\|SST)	Jun 29, 2012
4494	G16w Fetal human pancreas development (PDX1, PECAM1, INS)	Jun 29, 2012
4495	G16w Fetal human pancreas development (PDX1, PECAM1, INS)	Jun 29, 2012
4496	G16w Fetal human pancreas development (PDX1, PECAM1, INS)	Jun 29, 2012
4497	G16w Fetal human pancreas development (PDX1, PECAM1, INS)	Jun 29, 2012
4498	G16w Fetal human pancreas development (TUBB3, PECAM1, GCG\|INS\|SST)	Jun 29, 2012
4499	G16w Fetal human pancreas development (TUBB3, PECAM1, GCG\|INS\|SST)	Jun 29, 2012
4500	G16w Fetal human pancreas development (TUBB3, PECAM1, GCG\|INS\|SST)	Jun 29, 2012
4501	G16w Fetal human pancreas development (TUBB3, PECAM1, GCG\|INS\|SST)	Jun 29, 2012
4502	G7w Fetal human pancreas development (HNF1B, ONECUT1, CDH1)	Jun 29, 2012
4503	G7w Fetal human pancreas development (HNF1B, ONECUT1, CDH1)	Jun 29, 2012
4504	G7w Fetal human pancreas development (HNF1B, ONECUT1, CDH1)	Jun 29, 2012
4505	G7w Fetal human pancreas development (HNF1B, ONECUT1, CDH1)	Jun 29, 2012
4506	G7w Fetal human pancreas development (PTF1A, FOXA2, CDH1)	Jun 29, 2012
4507	G7w Fetal human pancreas development (PTF1A, FOXA2, CDH1)	Jun 29, 2012
4508	G7w Fetal human pancreas development (PTF1A, FOXA2, CDH1)	Jun 29, 2012
4509	G7w Fetal human pancreas development (SOX9, , )	Jun 29, 2012
4510	G7w Fetal human pancreas development (SOX9, , )	Jun 29, 2012
4511	G7w Fetal human pancreas development (SOX9, , )	Jun 29, 2012
4512	G7w Fetal human pancreas development (F3, PDX1, CDH1)	Jun 29, 2012
4513	G7w Fetal human pancreas development (ACE, PDX1, CDH1)	Jun 29, 2012
4514	G7w Fetal human pancreas development (CDH5, PDX1, CDH1)	Jun 29, 2012
4515	G7w Fetal human pancreas development (MAFB, GCG, PDX1)	Jun 29, 2012
4516	G7w Fetal human pancreas development (MAFB, GCG, PDX1)	Jun 29, 2012
4517	G7w Fetal human pancreas development (MAFB, INS, PDX1)	Jun 29, 2012
4518	G7w Fetal human pancreas development (MAFB, INS, PDX1)	Jun 29, 2012
4519	G7w Fetal human pancreas development (, PAX6, CDH1)	Jun 29, 2012
4520	G7w Fetal human pancreas development (PDX1, MKI67, CDH1)	Jun 29, 2012
4521	G7w Fetal human pancreas development (PDX1, MKI67, INS)	Jun 29, 2012
4522	G7w Fetal human pancreas development (PTF1A, CPA1, CDH1)	Jun 29, 2012
4523	G7w Fetal human pancreas development (PTF1A, CPA1, CDH1)	Jun 29, 2012
4524	G7w Fetal human pancreas development (SOX17, PDX1, CDH1)	Jun 29, 2012
4525	G7w Fetal human pancreas development (SOX18, PDX1, CDH1)	Jun 29, 2012
4526	G7w Fetal human pancreas development (Sox19, PDX1, CDH1)	Jun 29, 2012
4529	Neurog3^Cre-ER.BAC	Aug 2, 2012	Yes
4536	Neurog3^RG.BAC	Sep 5, 2012	Yes
4548	Polyclonal Mouse Ngn3 raised in Chicken	Oct 3, 2012	Yes
4549	Polyclonal Mouse Ngn3 raised in Chicken	Oct 3, 2012	Yes
4550	Polyclonal Mouse Nkx6.1 raised in Chicken	Oct 3, 2012	Yes
4551	Polyclonal Mouse Nkx6.1 raised in Chicken	Oct 3, 2012	Yes
4552	Polyclonal Mouse PDX1 raised in Chicken	Oct 3, 2012	Yes
4553	Polyclonal Mouse PDX1 raised in Chicken	Oct 3, 2012	Yes
4554	Polyclonal Mouse Prox1 raised in Chicken	Oct 3, 2012	Yes
4555	Polyclonal Mouse Prox1 raised in Chicken	Oct 3, 2012	Yes
91 completed resources viewable