Gordon Weir - Investigator Profile
My groups interests are on the phenotype and function of pancreatic beta cells in the in vivo environment, whether they be in models of diabetes such as rats with partial pancreatectomy or glucose infusions, or with transplanted islets placed into a site such under the kidney capsule or in alginate beads transplanted into the peritoneal cavity. Recent work has focused upon assessment of transplanted human islets, and the development of immature porcine islet tissue and various other precursor/stem cells when transplanted. The tools include analysis of gene expression, immunostaining, quantitative morphometry, and measurement of insulin storage and secretion. Our laboratory produces human islets for the JDRF/Harvard clinical islet transplantation program.
Scientific Interests/Keywords
Islet Cells
Publications
| Publication | Citation |
|---|---|
| 12694544 | Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, Weir GC Macrophage depletion improves survival of porcine neonatal pancreatic cell (2003) Xenotransplantation 10: 240-51 (Added 2005-04-13 13:00:38) |
| 12438314 | Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC Critical reduction in beta-cell mass results in two distinct outcomes over (2003) J Biol Chem 278: 2997-3005 (Added 2005-04-13 12:51:30) |
| 12099634 | Matarazzo M, Giardina MG, Guardasole V, Davalli AM, Horton ES, Weir GC, Sacca L, Napoli R Islet transplantation under the kidney capsule corrects the defects in (2002) Cell Transplant 11: 103-12 (Added 2005-04-13 13:02:37) |
| 12031967 | Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S Overexpression of c-Myc in beta-cells of transgenic mice causes (2002) Diabetes 51: 1793-804 (Added 2005-04-13 13:02:34) |
| 12011047 | Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC Involvement of c-Jun N-terminal kinase in oxidative stress-mediated (2002) J Biol Chem 277: 30010-8 (Added 2005-04-13 13:00:35) |
| 11812749 | Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC Increased expression of antioxidant and antiapoptotic genes in islets that (2002) Diabetes 51: 413-23 (Added 2005-04-13 13:00:28) |
| 11799123 | Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC Induction of c-Myc expression suppresses insulin gene transcription by (2002) J Biol Chem 277: 12998-3006 (Added 2005-04-13 13:00:33) |
| 11782487 | Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC Genetic regulation of metabolic pathways in beta-cells disrupted by (2002) J Biol Chem 277: 10912-21 (Added 2005-04-13 13:00:30) |
| 11714718 | Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC Involvement of protein kinase C beta 2 in c-myc induction by high glucose (2002) J Biol Chem 277: 3680-5 (Added 2005-04-13 12:54:09) |
| 11473027 | Duvivier-Kali VF, Omer A, Parent RJ, O'Neil JJ, Weir GC Complete protection of islets against allorejection and autoimmunity by a (2001) Diabetes 50: 1698-705 (Added 2005-04-13 12:54:07) |
| 11390407 | Kaneto H, Xu G, Song KH, Suzuma K, Bonner-Weir S, Sharma A, Weir GC Activation of the hexosamine pathway leads to deterioration of pancreatic (2001) J Biol Chem 276: 31099-104 (Added 2005-04-13 13:04:46) |
| 11272186 | Laybutt R, Hasenkamp W, Groff A, Grey S, Jonas JC, Kaneto H, Sharma A, Bonner-Weir S, Weir G beta-cell adaptation to hyperglycemia. (2001) Diabetes 50 Suppl 1: S180-1 (Added 2005-04-13 13:02:39) |
| 11272180 | Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A Beta-cell adaptation and decompensation during the progression of (2001) Diabetes 50 Suppl 1: S154-9 (Added 2005-04-13 12:50:49) |
