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Ole Madsen, Ph.D.

Principal Investigator
Hagedorn Research Institute
Beta Cell Biology

Niels Steensens Vej 6
Gentofte, DK-2820
Denmark

p. +45 4443 9197
f. +45 4443 8000
· email
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Ole Madsen, Ph.D. - Investigator Profile

I have a longstanding interest in processes controlling beta-cell maturation. We have for several years studied pluripotent islet tumor cells - from which destinct hormone producing islet tumors could be derived from common clonal origin. More recently, we have studied processes of pancreas and islet beta-cell ontogeny. We are much interested in the signal transduction processes controlling pancreatic endocrine maturation. Much of our current focus relates to the translational aspect of developmental biology to coax pluripotent stem cell differentiation towards therapeutic beta cells for diabetes treatment. 

Our main focus with the BCBC is to generate novel antibody tools for important factors/markers for the different stages of pancreatic maturation. Such reagents will be made available through the Antibody Core.

Scientific Interests/Keywords

antibody, cell surface, epitope, extracellular, cell lineage tracing, fluorescent cells, antibody tags, cell sorting, cell separation, cell culture, antibody mediated cell purification, protocol development.

Publication Citation
22096075 Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. (2012) Development 139: 33-45 (Added 2012-11-29 07:21:50.599334)
21947380 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C, Jensen JN, Madsen OD Pancreatic islet and progenitor cell surface markers with cell sorting potential. (2012) Diabetologia 55: 154-65 (Added 2012-12-19 04:20:18.105766)
21824258 Jensen PB, Larsen PJ, Karlsen C, Jensen HI, Holst JJ, Madsen OD Foetal proglucagon processing in relation to adult appetite control: lessons from a transplantable rat glucagonoma with severe anorexia. (2011) Diabetes Obes Metab 13 Suppl 1: 60-8 (Added 2011-08-30 12:00:29.817176)
21822931 Torekov SS, Ma L, Grarup N, Hartmann B, Hainerová IA, Kielgast U, Kissow H, Rosenkilde M, GIANT Consortium, Lebl J, Witte DR, Jørgensen T, Sandbaek A, Lauritzen T, Madsen OD, Wang J, Linneberg A, Madsbad S, Holst JJ, Hansen T, Pedersen O Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1. (2011) Diabetologia : (Added 2011-08-30 12:00:33.433266)
21099298 Heller RS, Tsugu H, Nabeshima K, Madsen OD Intracranial ectopic pancreatic tissue. () Islets 2: 65-71 (Added 2011-03-08 05:22:56.709671)
20920405 Engberg N, Hansson M, Madsen OD [From stem cells to functional beta cells in type 1 diabetes]. (2010) Ugeskr Laeger 172: 2608-12 (Added 2011-03-08 05:22:56.720662)
20558340 Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels. (2010) Eur J Histochem 54: e19 (Added 2013-01-08 04:10:54.601995)
20336589 Hansson M, Madsen OD Pluripotent stem cells, a potential source of beta-cells for diabetes therapy. (2010) Curr Opin Investig Drugs 11: 417-25 (Added 2010-08-18 09:36:45.46154)
19665969 Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. (2009) Cell 138: 449-62 (Added 2010-08-30 11:30:00.795581)
19213833 Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. (2009) Endocrinology 150: 2577-85 (Added 2012-11-29 06:10:54.353517)
18845151 Gustavsen CR, Chevret P, Krasnov B, Mowlavi G, Madsen OD, Heller RS The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds. (2008) Gen Comp Endocrinol 159: 241-9 (Added 2010-01-26 06:05:52.794733)
18665014 Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction. (2009) Pancreas 38: 36-48 (Added 2010-12-23 12:47:49.269605)
18347078 Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. (2008) J Histochem Cytochem 56: 587-95 (Added 2013-06-13 05:39:54.663221)
18212389 Klinck R, Serup P, Madsen OD, Jørgensen MC Specificity of four monoclonal anti-NKx6-1 antibodies. (2008) J Histochem Cytochem 56: 415-24 (Added 2010-01-26 06:08:02.324564)
17881611 Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J An illustrated review of early pancreas development in the mouse. (2007) Endocr Rev 28: 685-705 (Added 2010-01-26 06:08:34.952313)
17631449 Madsen OD Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. (2007) C R Biol 330: 534-7 (Added 2007-08-07 00:00:00)
17478445 Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. (2007) J Histochem Cytochem 55: 925-30 (Added 2010-01-26 06:10:17.230675)
17160042 Madsen OD, Serup P Towards cell therapy for diabetes. (2006) Nat Biotechnol 24: 1481-3 (Added 2007-08-07 03:27:05)
17053071 Narendran P, Neale AM, Lee BH, Ngui K, Steptoe RJ, Morahan G, Madsen O, Dromey JA, Jensen KP, Harrison LC Proinsulin is encoded by an RNA splice variant in human blood myeloid cells. (2006) Proc Natl Acad Sci U S A 103: 16430-5 (Added 2007-08-07 03:26:24)
16984985 Hainerova I, Torekov SS, Ek J, Finkova M, Borch-Johnsen K, Jorgensen T, Madsen OD, Lebl J, Hansen T, Pedersen O Association between neuromedin U gene variants and overweight and obesity. (2006) J Clin Endocrinol Metab 91: 5057-63 (Added 2007-08-07 03:25:45)
16480455 Madsen OD Stem cells and diabetes treatment. (2005) APMIS 113: 858-75 (Added 2007-08-07 03:25:12)
16401696 Pedersen IL, Klinck R, Hecksher-Sorensen J, Zahn S, Madsen OD, Serup P, Jorgensen MC Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1. (2006) J Histochem Cytochem 54: 567-74 (Added 2013-01-08 01:47:13.181558)
16122727 Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P Genetic determinants of pancreatic epsilon-cell development. (2005) Dev Biol 286: 217-24 (Added 2012-10-30 06:24:25.335127)
15983231 Torekov SS, Larsen LH, Glumer C, Borch-Johnsen K, Jorgensen T, Holst JJ, Madsen OD, Hansen T, Pedersen O Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. (2005) Diabetes 54: 2261-5 (Added 2007-08-07 03:23:05)
15684667 Zahn S, Pedersen J, Serup IL, Madsen P Generation of monoclonal antibodies against mouse neurogenin 3: a new immunocytochemical tool to study the pancreatic endocrine progenitor cell. (2004) Hybrid Hybridomics 23: 385-8 (Added 2005-06-20 02:52:58)
15543206 Rescan C, Lefebvre S, Frandsen VH, Klein U, Foschi T, Pipeleers M, Scharfmann DG, Madsen R, Heimberg OD EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. (2005) Lab Invest 85: 65-74 (Added 2005-06-20 02:43:27)
15031110 Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB, Madsen OD, Serup P The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. (2004) Dev Biol 268: 123-34 (Added 2005-06-20 02:43:08)
14686787 Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. (2003) Gene Expr 11: 141-7 (Added 2005-06-20 02:42:50)
12921743 Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. (2003) Dev Biol 260: 426-37 (Added 2005-06-20 02:42:30)
12754281 Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P Nestin is expressed in vascular endothelial cells in the adult human pancreas. (2003) J Histochem Cytochem 51: 697-706 (Added 2005-06-20 02:42:09)
12412008 Heller RS, Dichmann DS, Jensen J, Miller C, Wong G, Madsen OD, Serup P Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. (2002) Dev Dyn 225: 260-70 (Added 2005-06-20 02:41:38)
12403815 Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. (2002) J Cell Biol 159: 303-12 (Added 2010-12-23 12:45:13.461176)
11423476 Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P Improved glucose tolerance and acinar dysmorphogenesis by targeted (2001) Diabetes 50: 1553-61 (Added 2005-04-13 12:56:01)
11141151 Serup P, Madsen OD, Mandrup-Poulsen T Islet and stem cell transplantation for treating diabetes. (2001) BMJ 322: 29-32 (Added 2005-04-13 13:07:23)
10969830 Ammendrup A, Maillard A, Nielsen K, Aabenhus Andersen N, Serup P, Dragsbaek Madsen O, Mandrup-Poulsen T, Bonny C The c-Jun amino-terminal kinase pathway is preferentially activated by (2000) Diabetes 49: 1468-76 (Added 2005-04-13 12:56:03)
10891400 Petersen HV, Jorgensen MC, Andersen FG, Jensen J, F-Nielsen T, Jorgensen R, Madsen OD, Serup P Pax4 represses pancreatic glucagon gene expression. (2000) Mol Cell Biol Res Commun 3: 249-54 (Added 2005-04-13 12:58:11)
10868931 Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P Independent development of pancreatic alphaand beta-cells from (2000) Diabetes 49: 163-76 (Added 2005-04-13 13:07:26)
10825208 Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP Transcription factor hepatocyte nuclear factor 6 regulates pancreatic (2000) Mol Cell Biol 20: 4445-54 (Added 2005-04-13 12:58:13)
10628902 Tyrberg B, Eizirik DL, Marklund SL, Olejnicka B, Madsen OD, Andersson A Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity. (1999) Pharmacol Toxicol 85: 269-75 (Added 2010-08-18 09:38:31.231565)
10615124 Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD Control of endodermal endocrine development by Hes-1. (2000) Nat Genet 24: 36-44 (Added 2005-04-13 13:07:29)
10580420 Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J Beta-cell maturation leads to in vitro sensitivity to cytotoxins. (1999) Diabetes 48: 2324-32 (Added 2010-08-18 09:38:31.237488)
10567713 Jørgensen MC, Vestergård Petersen H, Ericson J, Madsen OD, Serup P Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1. (1999) FEBS Lett 461: 287-94 (Added 2010-08-18 09:38:31.242442)
10424881 Tingstedt JE, Edlund H, Madsen OD, Larsson LI Gastric amylin expression. Cellular identity and lack of requirement for the homeobox protein PDX-1. A study in normal and PDX-1-deficient animals with a cautionary note on antiserum evaluation. (1999) J Histochem Cytochem 47: 973-80 (Added 2010-08-18 09:38:31.247016)
10375461 Luna G, Francini F, Gómez Dumm CL, Madsen O, Gagliardino JJ Hormone coexpression in the adult toad endocrine pancreas: double-label immunofluorescence under basal conditions and after glucose injection. (1999) Gen Comp Endocrinol 115: 29-36 (Added 2010-08-18 09:38:31.252668)
10214934 Jensen PB, Kristensen P, Clausen JT, Judge ME, Hastrup S, Thim L, Wulff BS, Foged C, Jensen J, Holst JJ, Madsen OD The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans. (1999) FEBS Lett 447: 139-43 (Added 2010-08-18 09:38:31.258827)
10094480 Andersen FG, Jensen J, Heller RS, Petersen HV, Larsson LI, Madsen OD, Serup P Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. (1999) FEBS Lett 445: 315-20 (Added 2010-08-18 09:38:31.263897)
10094478 Andersen FG, Heller RS, Petersen HV, Jensen J, Madsen OD, Serup P Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element. (1999) FEBS Lett 445: 306-10 (Added 2010-08-18 09:38:31.269083)
9870681 Azzoni C, D'Adda T, Tamburrano G, Coscelli C, Madsen OD, Scopsi L, Bordi C Functioning human insulinomas. An immunohistochemical analysis of intracellular insulin processing. (1998) Virchows Arch 433: 495-504 (Added 2010-08-18 09:38:31.273894)
9714543 Petersen HV, Peshavaria M, Pedersen AA, Philippe J, Stein R, Madsen OD, Serup P Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor. (1998) FEBS Lett 431: 362-6 (Added 2010-08-18 09:44:26.94803)
9603781 Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). (1998) J Histochem Cytochem 46: 707-15 (Added 2010-08-18 09:44:26.952525)
9590691 Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S Hypothalamic CART is a new anorectic peptide regulated by leptin. (1998) Nature 393: 72-6 (Added 2010-08-18 09:44:26.956227)
9435324 Jensen PB, Blume N, Mikkelsen JD, Larsen PJ, Jensen HI, Holst JJ, Madsen OD Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus. (1998) J Clin Invest 101: 503-10 (Added 2010-08-18 09:44:26.960273)
9230347 Madsen OD, Jensen J, Petersen HV, Pedersen EE, Oster A, Andersen FG, Jørgensen MC, Jensen PB, Larsson LI, Serup P Transcription factors contributing to the pancreatic beta-cell phenotype. (1997) Horm Metab Res 29: 265-70 (Added 2010-08-18 09:44:26.964413)
9025070 Larsson LI, Madsen OD, Serup P, Jonsson J, Edlund H Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning. (1996) Mech Dev 60: 175-84 (Added 2010-08-18 09:44:26.972655)
9022666 Madsen OD, Jensen J, Blume N, Petersen HV, Lund K, Karlsen C, Andersen FG, Jensen PB, Larsson LI, Serup P Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet cultures. (1996) Eur J Biochem 242: 435-45 (Added 2010-08-18 09:44:26.968615)
8799146 Serup P, Jensen J, Andersen FG, Jørgensen MC, Blume N, Holst JJ, Madsen OD Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. (1996) Proc Natl Acad Sci U S A 93: 9015-20 (Added 2010-08-18 09:44:26.976725)
8702531 Jensen J, Serup P, Karlsen C, Nielsen TF, Madsen OD mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. (1996) J Biol Chem 271: 18749-58 (Added 2013-05-15 06:03:07.808149)
8692940 Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. (1996) Proc Natl Acad Sci U S A 93: 7036-41 (Added 2010-08-18 09:54:49.530355)
8501199 Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. (1993) Hum Reprod 8: 635-41 (Added 2010-08-18 09:54:49.566965)
8421685 Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. (1993) Proc Natl Acad Sci U S A 90: 527-31 (Added 2010-08-18 09:56:05.706358)
8404649 Madsen OD, Karlsen C, Nielsen E, Lund K, Kofod H, Welinder B, Rehfeld JF, Larsson LI, Steiner DF, Holst JJ The dissociation of tumor-induced weight loss from hypoglycemia in a transplantable pluripotent rat islet tumor results in the segregation of stable alpha- and beta-cell tumor phenotypes. (1993) Endocrinology 133: 2022-30 (Added 2010-08-18 09:54:49.562478)
8148038 Lund K, Blume N, Michelsen BK, Bucchini D, Madsen OD Differential expression of non-allelic insulin genes in rodent islet tumour cells. (1993) J Mol Endocrinol 11: 305-18 (Added 2010-08-18 09:54:49.557476)
7937976 Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. (1994) Proc Natl Acad Sci U S A 91: 10465-9 (Added 2010-08-18 09:54:49.55281)
7652479 Madsen OD, Karlsen C, Blume N, Jensen HI, Larsson LI, Holst JJ Transplantable glucagonomas derived from pluripotent rat islet tumor tissue cause severe anorexia and adipsia. (1995) Scand J Clin Lab Invest Suppl 220: 27-35 (Added 2010-08-18 09:54:49.547954)
7593609 Blume N, Skouv J, Larsson LI, Holst JJ, Madsen OD Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. (1995) J Clin Invest 96: 2227-35 (Added 2010-08-18 09:54:49.535568)
7575438 Serup P, Petersen HV, Pedersen EE, Edlund H, Leonard J, Petersen JS, Larsson LI, Madsen OD The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. (1995) Biochem J 310 ( Pt 3): 997-1003 (Added 2010-08-18 09:54:49.540453)
7540573 Karlsen AE, Andersen HU, Vissing H, Larsen PM, Fey SJ, Cuartero BG, Madsen OD, Petersen JS, Mortensen SB, Mandrup-Poulsen T Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans. (1995) Diabetes 44: 753-8 (Added 2010-08-18 09:54:49.544233)
6207064 Madsen OD, Frank BH, Steiner DF Human proinsulin-specific antigenic determinants identified by monoclonal antibodies. (1984) Diabetes 33: 1012-6 (Added 2010-11-09 10:27:29.31922)
6196183 Madsen OD, Cohen RM, Fitch FW, Rubenstein AH, Steiner DF The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure. (1983) Endocrinology 113: 2135-44 (Added 2010-11-09 10:27:02.286626)
3896518 Orci L, Ravazzola M, Amherdt M, Madsen O, Vassalli JD, Perrelet A Direct identification of prohormone conversion site in insulin-secreting cells. (1985) Cell 42: 671-81 (Added 2010-08-18 10:00:26.765871)
3537136 Contreas G, Madsen OD, Vissing H, Lernmark A A simple assay for the detection of antibodies to endocrine islet cell surface antigens. (1986) J Immunol Methods 95: 135-9 (Added 2010-08-18 10:00:26.749812)
3536964 Orci L, Ravazzola M, Amherdt M, Madsen O, Perrelet A, Vassalli JD, Anderson RG Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. (1986) J Cell Biol 103: 2273-81 (Added 2010-08-18 10:00:26.753992)
3516766 Madsen OD, Olsson ML, Bille G, Sundkvist G, Lernmark A, Dahlqvist G, Ludvigsson J A two-colour immunofluorescence test with a monoclonal human proinsulin antibody improves the assay for islet cell antibodies. (1986) Diabetologia 29: 115-8 (Added 2010-08-18 10:00:26.761914)
2877997 Madsen OD, Larsson LI, Rehfeld JF, Schwartz TW, Lernmark A, Labrecque AD, Steiner DF Cloned cell lines from a transplantable islet cell tumor are heterogeneous and express cholecystokinin in addition to islet hormones. (1986) J Cell Biol 103: 2025-34 (Added 2010-08-18 10:00:26.757859)
2842785 Madsen OD, Andersen LC, Michelsen B, Owerbach D, Larsson LI, Lernmark A, Steiner DF Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo. (1988) Proc Natl Acad Sci U S A 85: 6652-6 (Added 2010-08-18 09:59:10.55977)
2805585 Contreas G, Dyrberg T, Madsen OD, Markholst H, Lernmark A Increased levels of circulating immune complexes are not associated with diabetes in BB rats. (1989) Diabetes Res 10: 109-13 (Added 2010-08-18 09:59:10.544027)
2663499 Larsson LI, Nielsen JH, Hutton JC, Madsen OD Pancreatic hormones are expressed on the surfaces of human and rat islet cells through exocytotic sites. (1989) Eur J Cell Biol 48: 45-51 (Added 2010-08-18 09:59:10.547969)
2644530 Nielsen JH, Linde S, Welinder BS, Billestrup N, Madsen OD Growth hormone is a growth factor for the differentiated pancreatic beta-cell. (1989) Mol Endocrinol 3: 165-73 (Added 2010-08-18 09:59:10.555732)
2644126 Bucchini D, Madsen O, Desbois P, Pictet R, Jami J B islet cells of pancreas are the site of expression of the human insulin gene in transgenic mice. (1989) Exp Cell Res 180: 467-74 (Added 2010-08-18 09:59:10.551911)
2550269 Beck TC, Madsen OD Monoclonal antibodies as probes to the differentiated exocrine pancreas react to monoclonal islet tumor tissue. (1989) Exp Clin Endocrinol 93: 255-60 (Added 2010-08-18 09:59:10.540053)
2443408 Madsen OD Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion. (1987) Diabetes 36: 1203-11 (Added 2010-08-18 10:00:26.745211)
2274051 Fromont-Racine M, Bucchini D, Madsen O, Desbois P, Linde S, Nielsen JH, Saulnier C, Ripoche MA, Jami J, Pictet R Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice. (1990) Mol Endocrinol 4: 669-77 (Added 2010-08-18 09:57:36.400886)
2199167 Madsen OD, Contreas G, Jørgensen J Monoclonal (auto)antibodies in insulin-dependent diabetes mellitus. (1990) Curr Top Microbiol Immunol 156: 75-86 (Added 2010-08-18 09:57:36.404437)
2169420 Nielsen E, Welinder B, Madsen OD Protein HMG-17 is hyper-expressed in rat glucagonoma. Single-step isolation and sequencing. (1990) Eur J Biochem 192: 81-6 (Added 2010-08-18 09:57:36.39717)
2122446 Contreas G, Jørgensen J, Madsen OD Novel islet, duct, and acinar cell markers defined by monoclonal autoantibodies from prediabetic BB rats. (1990) Pancreas 5: 540-7 (Added 2010-08-18 09:57:36.393358)
1989847 Fürnsinn C, Komjati M, Madsen OD, Schneider B, Waldhäusl W Lifelong sequential changes in glucose tolerance and insulin secretion in genetically obese Zucker rats (fa/fa) fed a diabetogenic diet. (1991) Endocrinology 128: 1093-9 (Added 2010-08-18 09:57:36.385939)
1954895 Nielsen E, Welinder BS, Madsen OD Chromogranin-B, a putative precursor of eight novel rat glucagonoma peptides through processing at mono-, di-, or tribasic residues. (1991) Endocrinology 129: 3147-56 (Added 2010-08-18 09:56:05.728217)
1924335 Michelsen BK, Petersen JS, Boel E, Møldrup A, Dyrberg T, Madsen OD Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus. (1991) Proc Natl Acad Sci U S A 88: 8754-8 (Added 2010-08-18 09:57:36.382045)
1850107 Madsen OD, Nielsen JH, Michelsen B, Westermark P, Betsholtz C, Nishi M, Steiner DF Islet amyloid polypeptide and insulin expression are controlled differently in primary and transformed islet cells. (1991) Mol Endocrinol 5: 143-8 (Added 2010-08-18 09:57:36.389723)
1734887 De Vroede M, Foriers A, Van de Winkel M, Madsen O, Pipeleers D Presence of islet amyloid polypeptide in rat islet B and D cells determines parallelism and dissociation between rat pancreatic islet amyloid polypeptide and insulin content. (1992) Biochem Biophys Res Commun 182: 886-93 (Added 2010-08-18 09:56:05.724358)
1569972 Blume N, Petersen JS, Andersen LC, Kofod H, Dyrberg T, Michelsen BK, Serup P, Madsen OD Immature transformed rat islet beta-cells differentially express C-peptides derived from the genes coding for insulin I and II as well as a transfected human insulin gene. (1992) Mol Endocrinol 6: 299-307 (Added 2010-08-18 09:56:05.719642)
1563584 In 't Veld PA, Zhang F, Madsen OD, Klöppel G Islet amyloid polypeptide immunoreactivity in the human fetal pancreas. (1992) Diabetologia 35: 272-6 (Added 2010-08-18 09:56:05.715903)
1406710 Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. (1992) Mol Endocrinol 6: 1332-42 (Added 2010-08-18 09:56:05.712155)
Resource ID Name Contributed on Primary Contributor
266 Polyclonal Rat IAPP raised in Rabbit Jun 2, 2003 Yes
267 Polyclonal Rat C-peptide 2 raised in Rabbit Jun 2, 2003 Yes
268 Polyclonal Rat C-peptide 1 raised in Rabbit Jun 2, 2003 Yes
269 Polyclonal Mouse C-peptide 1 raised in Rabbit Jun 2, 2003 Yes
270 Monoclonal Human Insulin raised in Mouse Jul 2, 2003 Yes
271 Polyclonal Rat PDX1 raised in Rabbit Jul 2, 2003 Yes
272 Polyclonal Rat PDX1 raised in Rabbit Jul 2, 2003 Yes
273 Polyclonal Rat Nkx6.1 raised in Rabbit Jul 2, 2003 Yes
275 Polyclonal Human ghrelin raised in Goat Sep 22, 2003 Yes
276 Polyclonal Mouse Pax6 raised in Rabbit Sep 22, 2003 Yes
277 Polyclonal Human b-catenin raised in Goat Sep 22, 2003 Yes
278 Monoclonal Mouse smooth muscle actin raised in Mouse Sep 22, 2003 Yes
279 Polyclonal Human amylase raised in Rabbit Sep 22, 2003 Yes
280 Polyclonal Human c-myc raised in Rabbit Sep 23, 2003 Yes
281 Polyclonal Rat Glut-2 raised in Rabbit Sep 23, 2003 Yes
282 Polyclonal bovine Carboxypeptidase A raised in Rabbit Sep 23, 2003 Yes
283 Polyclonal Human Chromogranin A raised in Rabbit Sep 23, 2003 Yes
284 Monoclonal Human Chromogranin A raised in Mouse Sep 23, 2003 Yes
285 Monoclonal Human Cytokeratin 7 raised in Mouse Sep 23, 2003 Yes
286 Monoclonal Human PECAM-1 raised in Mouse Sep 23, 2003 Yes
287 Polyclonal Aequorea victoria Green Fluorescent Protein raised in Rabbit Sep 23, 2003 Yes
288 Monoclonal Chicken Nkx2.2 raised in Mouse Sep 25, 2003 Yes
289 Polyclonal Rat ghrelin raised in Rabbit Sep 25, 2003 Yes
290 Monoclonal Chicken Islet-1 raised in Mouse Sep 26, 2003 Yes
294 Polyclonal Mouse PDX1 raised in Chicken May 6, 2004 Yes
295 Monoclonal Human Glucagon raised in Mouse May 28, 2004 Yes
296 Monoclonal Human Somatostatin raised in Mouse May 28, 2004 Yes
297 Monoclonal Rat Pancreatic Ducts raised in Mouse Jun 30, 2004 Yes
298 Monoclonal Rat Pancreatic Ducts raised in Mouse Jul 1, 2004 Yes
299 Monoclonal Rat Islet Delta Cells raised in Rat Jul 1, 2004 Yes
300 Monoclonal Rat Pancreatic Ducts raised in Rat Jul 1, 2004 Yes
301 Monoclonal Human Pro-Insulin raised in Mouse Jul 1, 2004 Yes
302 Polyclonal Mouse Ngn3 raised in Rabbit Jul 1, 2004 Yes
303 Polyclonal Mouse Ngn3 raised in Rabbit Jul 1, 2004 Yes
304 Monoclonal Mouse Ngn3 raised in Mouse Jul 1, 2004 Yes
305 Monoclonal Mouse Ngn3 raised in Mouse Jul 1, 2004 Yes
307 Monoclonal Rat Nkx6.1 raised in Mouse Sep 24, 2004 Yes
308 Monoclonal Rat Nkx6.1 raised in Mouse Sep 27, 2004 Yes
309 Monoclonal Rat Nkx6.1 raised in Mouse Sep 27, 2004 Yes
310 Monoclonal Rat Nkx6.1 raised in Mouse Sep 27, 2004 Yes
312 Polyclonal Mouse PDX1 raised in Goat Nov 24, 2004 Yes
313 Polyclonal Mouse PDX1 raised in Guinea Pig Nov 24, 2004 Yes
314 Polyclonal Human ghrelin raised in Rabbit Dec 17, 2004 Yes
315 Polyclonal Human ghrelin raised in Rabbit Dec 17, 2004 Yes
316 Monoclonal Rat PDX1 raised in Mouse Jan 24, 2005 Yes
317 Monoclonal Rat PDX1 raised in Mouse Aug 5, 2005 Yes
318 Monoclonal Rat PDX1 raised in Mouse Aug 5, 2005 Yes
324 Polyclonal Human Sox17 raised in Rabbit Jun 12, 2006 Yes
325 Polyclonal Human Sox17 raised in Rabbit Jun 12, 2006 Yes
331 Polyclonal Human Sox17 raised in Goat Mar 19, 2007 Yes
332 Polyclonal Mouse Shh raised in Goat Apr 11, 2007 Yes
333 Polyclonal E. coli beta Galactosidase raised in Chicken Apr 11, 2007 Yes
334 Monoclonal Aequorea victoria Green Fluorescent Protein raised in Mouse Apr 11, 2007 Yes
335 Polyclonal Mouse Ptf1a raised in Rabbit Aug 29, 2007 Yes
336 Polyclonal Mouse IA1 (Insm-1) raised in Rabbit Aug 29, 2007 Yes
346 Polyclonal Human T (Brachyury) raised in Goat Apr 9, 2008 Yes
347 Polyclonal Mouse Laminin raised in Rabbit Apr 29, 2008 Yes
348 Monoclonal Chicken Pax6 raised in Mouse Apr 29, 2008 Yes
821 Monoclonal Mouse BetaTC6 raised in Mouse Feb 6, 2009 Yes
861 Polyclonal Rat CART raised in Rabbit Feb 9, 2009 Yes
961 Monoclonal Mouse BetaTC6 raised in Mouse Feb 11, 2009 Yes
962 Monoclonal Mouse BetaTC6 raised in Mouse Feb 11, 2009 Yes
964 Monoclonal Human Disp2 raised in Mouse Feb 11, 2009 Yes
965 Monoclonal Human Disp2 raised in Mouse Feb 11, 2009 Yes
966 Polyclonal Mouse Lrp11 raised in Rabbit Feb 11, 2009 Yes
967 Polyclonal Mouse Sez6l2 raised in Rabbit Feb 11, 2009 Yes
968 Polyclonal Mouse Sez6l2 raised in Rabbit Feb 11, 2009 Yes
969 Polyclonal Human DDR1 raised in Goat Feb 11, 2009 Yes
970 Monoclonal Human DDR1 raised in Mouse Feb 11, 2009 Yes
971 Polyclonal Mouse Gpr39-1a raised in Rabbit Feb 11, 2009 Yes
972 Polyclonal Rat CART raised in Rabbit Feb 11, 2009 Yes
974 Monoclonal Rat CART raised in Mouse Feb 11, 2009 Yes
1064 Neurogenin3 deficiency and Embryonic Pancreatic Gene Expression May 25, 2007 Yes
1161 Polyclonal Mouse Carboxypeptidase A1 (CPA1) raised in Goat Mar 9, 2009 Yes
1162 Polyclonal Human Muc1 raised in Rabbit Mar 9, 2009 Yes
1163 Polyclonal Human Cleaved Notch1 raised in Rabbit Mar 9, 2009 Yes
1164 Polyclonal Human Jagged1 raised in Goat Mar 9, 2009 Yes
2201 Polyclonal Mouse DNER raised in Goat Oct 13, 2009 Yes
2222 Monoclonal Rat Shh raised in Mouse Oct 14, 2009 Yes
2223 Monoclonal Chicken Chick HNF3Beta raised in Mouse Oct 14, 2009 Yes
2263 Polyclonal Mouse Pax4 raised in Guinea Pig Oct 20, 2009 Yes
2482 Polyclonal Mouse Ngn3 raised in Goat Nov 23, 2009 Yes
2922 Wholemount Immunofluorescence Feb 12, 2010 Yes
3022 Polyclonal Mouse Irx2 raised in Rabbit Mar 4, 2010 Yes
3023 Polyclonal Mouse Arx raised in Rabbit Mar 4, 2010 Yes
3102 Polyclonal Mouse mArx raised in Guinea Pig Apr 23, 2010 Yes
3185 Monoclonal Human C-peptide raised in Rat May 1, 2004 Yes
4040 Polyclonal Human TSPAN7 raised in Rabbit Nov 2, 2010 Yes
4041 Monoclonal Human FXYD2 raised in Mouse Nov 2, 2010 Yes
4047 Polyclonal Mouse Sez6l2 raised in Rabbit Jan 7, 2011 Yes
4048 Polyclonal Human Lrp11 raised in Rabbit Jan 7, 2011 Yes
4052 Polyclonal Mouse Onecut1 raised in Guinea Pig Mar 2, 2011 Yes
4113 Polyclonal Enterobacteria phage P1 Cre raised in Guinea Pig Jul 13, 2011 Yes
4129 Polyclonal Human Ngn3 raised in Sheep Sep 27, 2011 Yes
4130 Monoclonal Mouse Pax4 raised in Mouse Sep 27, 2011 Yes
4131 Monoclonal Mouse Pax4 raised in Mouse Sep 28, 2011 Yes
4132 Monoclonal Mouse Pax4 raised in Mouse Sep 28, 2011 Yes
4133 Monoclonal Human CD142 raised in Mouse Sep 28, 2011 Yes
4134 Monoclonal Rat Beta cell, IC2 raised in Rat Sep 29, 2011 Yes
4135 Polyclonal Human CD-200 raised in Goat Sep 29, 2011 Yes
4256 Polyclonal Human HIP-14 ZDHHC17 raised in Rabbit Mar 1, 2012 Yes
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