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Ole Madsen, Ph.D. - Investigator Profile
I have a longstanding interest in processes controlling beta-cell maturation. We have for several years studied pluripotent islet tumor cells - from which destinct hormone producing islet tumors could be derived from common clonal origin. More recently, we have studied processes of pancreas and islet beta-cell ontogeny. We are much interested in the signal transduction processes controlling pancreatic endocrine maturation. Much of our current focus relates to the translational aspect of developmental biology to coax pluripotent stem cell differentiation towards therapeutic beta cells for diabetes treatment.
Our main focus with the BCBC is to generate novel antibody tools for important factors/markers for the different stages of pancreatic maturation. Such reagents will be made available through the Antibody Core.
Scientific Interests/Keywords
antibody, cell surface, epitope, extracellular, cell lineage tracing, fluorescent cells, antibody tags, cell sorting, cell separation, cell culture, antibody mediated cell purification, protocol development.
| Publication | Citation |
|---|---|
| 22096075 | Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. (2012) Development 139: 33-45 (Added 2012-11-29 07:21:50.599334) |
| 21947380 | Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C, Jensen JN, Madsen OD Pancreatic islet and progenitor cell surface markers with cell sorting potential. (2012) Diabetologia 55: 154-65 (Added 2012-12-19 04:20:18.105766) |
| 21824258 | Jensen PB, Larsen PJ, Karlsen C, Jensen HI, Holst JJ, Madsen OD Foetal proglucagon processing in relation to adult appetite control: lessons from a transplantable rat glucagonoma with severe anorexia. (2011) Diabetes Obes Metab 13 Suppl 1: 60-8 (Added 2011-08-30 12:00:29.817176) |
| 21822931 | Torekov SS, Ma L, Grarup N, Hartmann B, Hainerová IA, Kielgast U, Kissow H, Rosenkilde M, GIANT Consortium, Lebl J, Witte DR, Jørgensen T, Sandbaek A, Lauritzen T, Madsen OD, Wang J, Linneberg A, Madsbad S, Holst JJ, Hansen T, Pedersen O Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1. (2011) Diabetologia : (Added 2011-08-30 12:00:33.433266) |
| 21099298 | Heller RS, Tsugu H, Nabeshima K, Madsen OD Intracranial ectopic pancreatic tissue. () Islets 2: 65-71 (Added 2011-03-08 05:22:56.709671) |
| 20920405 | Engberg N, Hansson M, Madsen OD [From stem cells to functional beta cells in type 1 diabetes]. (2010) Ugeskr Laeger 172: 2608-12 (Added 2011-03-08 05:22:56.720662) |
| 20558340 | Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels. (2010) Eur J Histochem 54: e19 (Added 2013-01-08 04:10:54.601995) |
| 20336589 | Hansson M, Madsen OD Pluripotent stem cells, a potential source of beta-cells for diabetes therapy. (2010) Curr Opin Investig Drugs 11: 417-25 (Added 2010-08-18 09:36:45.46154) |
| 19665969 | Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. (2009) Cell 138: 449-62 (Added 2010-08-30 11:30:00.795581) |
| 19213833 | Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. (2009) Endocrinology 150: 2577-85 (Added 2012-11-29 06:10:54.353517) |
| 18845151 | Gustavsen CR, Chevret P, Krasnov B, Mowlavi G, Madsen OD, Heller RS The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds. (2008) Gen Comp Endocrinol 159: 241-9 (Added 2010-01-26 06:05:52.794733) |
| 18665014 | Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction. (2009) Pancreas 38: 36-48 (Added 2010-12-23 12:47:49.269605) |
| 18347078 | Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. (2008) J Histochem Cytochem 56: 587-95 (Added 2010-01-26 06:07:23.307201) |
| 18212389 | Klinck R, Serup P, Madsen OD, Jørgensen MC Specificity of four monoclonal anti-NKx6-1 antibodies. (2008) J Histochem Cytochem 56: 415-24 (Added 2010-01-26 06:08:02.324564) |
| 17881611 | Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J An illustrated review of early pancreas development in the mouse. (2007) Endocr Rev 28: 685-705 (Added 2010-01-26 06:08:34.952313) |
| 17631449 | Madsen OD Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. (2007) C R Biol 330: 534-7 (Added 2007-08-07 00:00:00) |
| 17478445 | Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. (2007) J Histochem Cytochem 55: 925-30 (Added 2010-01-26 06:10:17.230675) |
| 17160042 | Madsen OD, Serup P Towards cell therapy for diabetes. (2006) Nat Biotechnol 24: 1481-3 (Added 2007-08-07 03:27:05) |
| 17053071 | Narendran P, Neale AM, Lee BH, Ngui K, Steptoe RJ, Morahan G, Madsen O, Dromey JA, Jensen KP, Harrison LC Proinsulin is encoded by an RNA splice variant in human blood myeloid cells. (2006) Proc Natl Acad Sci U S A 103: 16430-5 (Added 2007-08-07 03:26:24) |
| 16984985 | Hainerova I, Torekov SS, Ek J, Finkova M, Borch-Johnsen K, Jorgensen T, Madsen OD, Lebl J, Hansen T, Pedersen O Association between neuromedin U gene variants and overweight and obesity. (2006) J Clin Endocrinol Metab 91: 5057-63 (Added 2007-08-07 03:25:45) |
| 16480455 | Madsen OD Stem cells and diabetes treatment. (2005) APMIS 113: 858-75 (Added 2007-08-07 03:25:12) |
| 16401696 | Pedersen IL, Klinck R, Hecksher-Sorensen J, Zahn S, Madsen OD, Serup P, Jorgensen MC Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1. (2006) J Histochem Cytochem 54: 567-74 (Added 2013-01-08 01:47:13.181558) |
| 16122727 | Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P Genetic determinants of pancreatic epsilon-cell development. (2005) Dev Biol 286: 217-24 (Added 2012-10-30 06:24:25.335127) |
| 15983231 | Torekov SS, Larsen LH, Glumer C, Borch-Johnsen K, Jorgensen T, Holst JJ, Madsen OD, Hansen T, Pedersen O Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. (2005) Diabetes 54: 2261-5 (Added 2007-08-07 03:23:05) |
| 15684667 | Zahn S, Pedersen J, Serup IL, Madsen P Generation of monoclonal antibodies against mouse neurogenin 3: a new immunocytochemical tool to study the pancreatic endocrine progenitor cell. (2004) Hybrid Hybridomics 23: 385-8 (Added 2005-06-20 02:52:58) |
| 15543206 | Rescan C, Lefebvre S, Frandsen VH, Klein U, Foschi T, Pipeleers M, Scharfmann DG, Madsen R, Heimberg OD EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. (2005) Lab Invest 85: 65-74 (Added 2005-06-20 02:43:27) |
| 15031110 | Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB, Madsen OD, Serup P The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. (2004) Dev Biol 268: 123-34 (Added 2005-06-20 02:43:08) |
| 14686787 | Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. (2003) Gene Expr 11: 141-7 (Added 2005-06-20 02:42:50) |
| 12921743 | Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. (2003) Dev Biol 260: 426-37 (Added 2005-06-20 02:42:30) |
| 12754281 | Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P Nestin is expressed in vascular endothelial cells in the adult human pancreas. (2003) J Histochem Cytochem 51: 697-706 (Added 2005-06-20 02:42:09) |
| 12412008 | Heller RS, Dichmann DS, Jensen J, Miller C, Wong G, Madsen OD, Serup P Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. (2002) Dev Dyn 225: 260-70 (Added 2005-06-20 02:41:38) |
| 12403815 | Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. (2002) J Cell Biol 159: 303-12 (Added 2010-12-23 12:45:13.461176) |
| 11423476 | Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P Improved glucose tolerance and acinar dysmorphogenesis by targeted (2001) Diabetes 50: 1553-61 (Added 2005-04-13 12:56:01) |
| 11141151 | Serup P, Madsen OD, Mandrup-Poulsen T Islet and stem cell transplantation for treating diabetes. (2001) BMJ 322: 29-32 (Added 2005-04-13 13:07:23) |
| 10969830 | Ammendrup A, Maillard A, Nielsen K, Aabenhus Andersen N, Serup P, Dragsbaek Madsen O, Mandrup-Poulsen T, Bonny C The c-Jun amino-terminal kinase pathway is preferentially activated by (2000) Diabetes 49: 1468-76 (Added 2005-04-13 12:56:03) |
| 10891400 | Petersen HV, Jorgensen MC, Andersen FG, Jensen J, F-Nielsen T, Jorgensen R, Madsen OD, Serup P Pax4 represses pancreatic glucagon gene expression. (2000) Mol Cell Biol Res Commun 3: 249-54 (Added 2005-04-13 12:58:11) |
| 10868931 | Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P Independent development of pancreatic alphaand beta-cells from (2000) Diabetes 49: 163-76 (Added 2005-04-13 13:07:26) |
| 10825208 | Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP Transcription factor hepatocyte nuclear factor 6 regulates pancreatic (2000) Mol Cell Biol 20: 4445-54 (Added 2005-04-13 12:58:13) |
| 10628902 | Tyrberg B, Eizirik DL, Marklund SL, Olejnicka B, Madsen OD, Andersson A Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity. (1999) Pharmacol Toxicol 85: 269-75 (Added 2010-08-18 09:38:31.231565) |
| 10615124 | Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD Control of endodermal endocrine development by Hes-1. (2000) Nat Genet 24: 36-44 (Added 2005-04-13 13:07:29) |
| 10580420 | Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J Beta-cell maturation leads to in vitro sensitivity to cytotoxins. (1999) Diabetes 48: 2324-32 (Added 2010-08-18 09:38:31.237488) |
| 10567713 | Jørgensen MC, Vestergård Petersen H, Ericson J, Madsen OD, Serup P Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1. (1999) FEBS Lett 461: 287-94 (Added 2010-08-18 09:38:31.242442) |
| 10424881 | Tingstedt JE, Edlund H, Madsen OD, Larsson LI Gastric amylin expression. Cellular identity and lack of requirement for the homeobox protein PDX-1. A study in normal and PDX-1-deficient animals with a cautionary note on antiserum evaluation. (1999) J Histochem Cytochem 47: 973-80 (Added 2010-08-18 09:38:31.247016) |
| 10375461 | Luna G, Francini F, Gómez Dumm CL, Madsen O, Gagliardino JJ Hormone coexpression in the adult toad endocrine pancreas: double-label immunofluorescence under basal conditions and after glucose injection. (1999) Gen Comp Endocrinol 115: 29-36 (Added 2010-08-18 09:38:31.252668) |
| 10214934 | Jensen PB, Kristensen P, Clausen JT, Judge ME, Hastrup S, Thim L, Wulff BS, Foged C, Jensen J, Holst JJ, Madsen OD The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans. (1999) FEBS Lett 447: 139-43 (Added 2010-08-18 09:38:31.258827) |
| 10094480 | Andersen FG, Jensen J, Heller RS, Petersen HV, Larsson LI, Madsen OD, Serup P Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. (1999) FEBS Lett 445: 315-20 (Added 2010-08-18 09:38:31.263897) |
| 10094478 | Andersen FG, Heller RS, Petersen HV, Jensen J, Madsen OD, Serup P Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element. (1999) FEBS Lett 445: 306-10 (Added 2010-08-18 09:38:31.269083) |
| 9870681 | Azzoni C, D'Adda T, Tamburrano G, Coscelli C, Madsen OD, Scopsi L, Bordi C Functioning human insulinomas. An immunohistochemical analysis of intracellular insulin processing. (1998) Virchows Arch 433: 495-504 (Added 2010-08-18 09:38:31.273894) |
| 9714543 | Petersen HV, Peshavaria M, Pedersen AA, Philippe J, Stein R, Madsen OD, Serup P Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor. (1998) FEBS Lett 431: 362-6 (Added 2010-08-18 09:44:26.94803) |
| 9603781 | Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). (1998) J Histochem Cytochem 46: 707-15 (Added 2010-08-18 09:44:26.952525) |
| 9590691 | Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S Hypothalamic CART is a new anorectic peptide regulated by leptin. (1998) Nature 393: 72-6 (Added 2010-08-18 09:44:26.956227) |
| 9435324 | Jensen PB, Blume N, Mikkelsen JD, Larsen PJ, Jensen HI, Holst JJ, Madsen OD Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus. (1998) J Clin Invest 101: 503-10 (Added 2010-08-18 09:44:26.960273) |
| 9230347 | Madsen OD, Jensen J, Petersen HV, Pedersen EE, Oster A, Andersen FG, Jørgensen MC, Jensen PB, Larsson LI, Serup P Transcription factors contributing to the pancreatic beta-cell phenotype. (1997) Horm Metab Res 29: 265-70 (Added 2010-08-18 09:44:26.964413) |
| 9025070 | Larsson LI, Madsen OD, Serup P, Jonsson J, Edlund H Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning. (1996) Mech Dev 60: 175-84 (Added 2010-08-18 09:44:26.972655) |
| 9022666 | Madsen OD, Jensen J, Blume N, Petersen HV, Lund K, Karlsen C, Andersen FG, Jensen PB, Larsson LI, Serup P Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet cultures. (1996) Eur J Biochem 242: 435-45 (Added 2010-08-18 09:44:26.968615) |
| 8799146 | Serup P, Jensen J, Andersen FG, Jørgensen MC, Blume N, Holst JJ, Madsen OD Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. (1996) Proc Natl Acad Sci U S A 93: 9015-20 (Added 2010-08-18 09:44:26.976725) |
| 8702531 | Jensen J, Serup P, Karlsen C, Nielsen TF, Madsen OD mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. (1996) J Biol Chem 271: 18749-58 (Added 2013-05-15 06:03:07.808149) |
| 8692940 | Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. (1996) Proc Natl Acad Sci U S A 93: 7036-41 (Added 2010-08-18 09:54:49.530355) |
| 8501199 | Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. (1993) Hum Reprod 8: 635-41 (Added 2010-08-18 09:54:49.566965) |
| 8421685 | Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. (1993) Proc Natl Acad Sci U S A 90: 527-31 (Added 2010-08-18 09:56:05.706358) |
| 8404649 | Madsen OD, Karlsen C, Nielsen E, Lund K, Kofod H, Welinder B, Rehfeld JF, Larsson LI, Steiner DF, Holst JJ The dissociation of tumor-induced weight loss from hypoglycemia in a transplantable pluripotent rat islet tumor results in the segregation of stable alpha- and beta-cell tumor phenotypes. (1993) Endocrinology 133: 2022-30 (Added 2010-08-18 09:54:49.562478) |
| 8148038 | Lund K, Blume N, Michelsen BK, Bucchini D, Madsen OD Differential expression of non-allelic insulin genes in rodent islet tumour cells. (1993) J Mol Endocrinol 11: 305-18 (Added 2010-08-18 09:54:49.557476) |
| 7937976 | Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. (1994) Proc Natl Acad Sci U S A 91: 10465-9 (Added 2010-08-18 09:54:49.55281) |
| 7652479 | Madsen OD, Karlsen C, Blume N, Jensen HI, Larsson LI, Holst JJ Transplantable glucagonomas derived from pluripotent rat islet tumor tissue cause severe anorexia and adipsia. (1995) Scand J Clin Lab Invest Suppl 220: 27-35 (Added 2010-08-18 09:54:49.547954) |
| 7593609 | Blume N, Skouv J, Larsson LI, Holst JJ, Madsen OD Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. (1995) J Clin Invest 96: 2227-35 (Added 2010-08-18 09:54:49.535568) |
| 7575438 | Serup P, Petersen HV, Pedersen EE, Edlund H, Leonard J, Petersen JS, Larsson LI, Madsen OD The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. (1995) Biochem J 310 ( Pt 3): 997-1003 (Added 2010-08-18 09:54:49.540453) |
| 7540573 | Karlsen AE, Andersen HU, Vissing H, Larsen PM, Fey SJ, Cuartero BG, Madsen OD, Petersen JS, Mortensen SB, Mandrup-Poulsen T Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans. (1995) Diabetes 44: 753-8 (Added 2010-08-18 09:54:49.544233) |
| 6207064 | Madsen OD, Frank BH, Steiner DF Human proinsulin-specific antigenic determinants identified by monoclonal antibodies. (1984) Diabetes 33: 1012-6 (Added 2010-11-09 10:27:29.31922) |
| 6196183 | Madsen OD, Cohen RM, Fitch FW, Rubenstein AH, Steiner DF The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure. (1983) Endocrinology 113: 2135-44 (Added 2010-11-09 10:27:02.286626) |
| 3896518 | Orci L, Ravazzola M, Amherdt M, Madsen O, Vassalli JD, Perrelet A Direct identification of prohormone conversion site in insulin-secreting cells. (1985) Cell 42: 671-81 (Added 2010-08-18 10:00:26.765871) |
| 3537136 | Contreas G, Madsen OD, Vissing H, Lernmark A A simple assay for the detection of antibodies to endocrine islet cell surface antigens. (1986) J Immunol Methods 95: 135-9 (Added 2010-08-18 10:00:26.749812) |
| 3536964 | Orci L, Ravazzola M, Amherdt M, Madsen O, Perrelet A, Vassalli JD, Anderson RG Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. (1986) J Cell Biol 103: 2273-81 (Added 2010-08-18 10:00:26.753992) |
| 3516766 | Madsen OD, Olsson ML, Bille G, Sundkvist G, Lernmark A, Dahlqvist G, Ludvigsson J A two-colour immunofluorescence test with a monoclonal human proinsulin antibody improves the assay for islet cell antibodies. (1986) Diabetologia 29: 115-8 (Added 2010-08-18 10:00:26.761914) |
| 2877997 | Madsen OD, Larsson LI, Rehfeld JF, Schwartz TW, Lernmark A, Labrecque AD, Steiner DF Cloned cell lines from a transplantable islet cell tumor are heterogeneous and express cholecystokinin in addition to islet hormones. (1986) J Cell Biol 103: 2025-34 (Added 2010-08-18 10:00:26.757859) |
| 2842785 | Madsen OD, Andersen LC, Michelsen B, Owerbach D, Larsson LI, Lernmark A, Steiner DF Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo. (1988) Proc Natl Acad Sci U S A 85: 6652-6 (Added 2010-08-18 09:59:10.55977) |
| 2805585 | Contreas G, Dyrberg T, Madsen OD, Markholst H, Lernmark A Increased levels of circulating immune complexes are not associated with diabetes in BB rats. (1989) Diabetes Res 10: 109-13 (Added 2010-08-18 09:59:10.544027) |
| 2663499 | Larsson LI, Nielsen JH, Hutton JC, Madsen OD Pancreatic hormones are expressed on the surfaces of human and rat islet cells through exocytotic sites. (1989) Eur J Cell Biol 48: 45-51 (Added 2010-08-18 09:59:10.547969) |
| 2644530 | Nielsen JH, Linde S, Welinder BS, Billestrup N, Madsen OD Growth hormone is a growth factor for the differentiated pancreatic beta-cell. (1989) Mol Endocrinol 3: 165-73 (Added 2010-08-18 09:59:10.555732) |
| 2644126 | Bucchini D, Madsen O, Desbois P, Pictet R, Jami J B islet cells of pancreas are the site of expression of the human insulin gene in transgenic mice. (1989) Exp Cell Res 180: 467-74 (Added 2010-08-18 09:59:10.551911) |
| 2550269 | Beck TC, Madsen OD Monoclonal antibodies as probes to the differentiated exocrine pancreas react to monoclonal islet tumor tissue. (1989) Exp Clin Endocrinol 93: 255-60 (Added 2010-08-18 09:59:10.540053) |
| 2443408 | Madsen OD Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion. (1987) Diabetes 36: 1203-11 (Added 2010-08-18 10:00:26.745211) |
| 2274051 | Fromont-Racine M, Bucchini D, Madsen O, Desbois P, Linde S, Nielsen JH, Saulnier C, Ripoche MA, Jami J, Pictet R Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice. (1990) Mol Endocrinol 4: 669-77 (Added 2010-08-18 09:57:36.400886) |
| 2199167 | Madsen OD, Contreas G, Jørgensen J Monoclonal (auto)antibodies in insulin-dependent diabetes mellitus. (1990) Curr Top Microbiol Immunol 156: 75-86 (Added 2010-08-18 09:57:36.404437) |
| 2169420 | Nielsen E, Welinder B, Madsen OD Protein HMG-17 is hyper-expressed in rat glucagonoma. Single-step isolation and sequencing. (1990) Eur J Biochem 192: 81-6 (Added 2010-08-18 09:57:36.39717) |
| 2122446 | Contreas G, Jørgensen J, Madsen OD Novel islet, duct, and acinar cell markers defined by monoclonal autoantibodies from prediabetic BB rats. (1990) Pancreas 5: 540-7 (Added 2010-08-18 09:57:36.393358) |
| 1989847 | Fürnsinn C, Komjati M, Madsen OD, Schneider B, Waldhäusl W Lifelong sequential changes in glucose tolerance and insulin secretion in genetically obese Zucker rats (fa/fa) fed a diabetogenic diet. (1991) Endocrinology 128: 1093-9 (Added 2010-08-18 09:57:36.385939) |
| 1954895 | Nielsen E, Welinder BS, Madsen OD Chromogranin-B, a putative precursor of eight novel rat glucagonoma peptides through processing at mono-, di-, or tribasic residues. (1991) Endocrinology 129: 3147-56 (Added 2010-08-18 09:56:05.728217) |
| 1924335 | Michelsen BK, Petersen JS, Boel E, Møldrup A, Dyrberg T, Madsen OD Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus. (1991) Proc Natl Acad Sci U S A 88: 8754-8 (Added 2010-08-18 09:57:36.382045) |
| 1850107 | Madsen OD, Nielsen JH, Michelsen B, Westermark P, Betsholtz C, Nishi M, Steiner DF Islet amyloid polypeptide and insulin expression are controlled differently in primary and transformed islet cells. (1991) Mol Endocrinol 5: 143-8 (Added 2010-08-18 09:57:36.389723) |
| 1734887 | De Vroede M, Foriers A, Van de Winkel M, Madsen O, Pipeleers D Presence of islet amyloid polypeptide in rat islet B and D cells determines parallelism and dissociation between rat pancreatic islet amyloid polypeptide and insulin content. (1992) Biochem Biophys Res Commun 182: 886-93 (Added 2010-08-18 09:56:05.724358) |
| 1569972 | Blume N, Petersen JS, Andersen LC, Kofod H, Dyrberg T, Michelsen BK, Serup P, Madsen OD Immature transformed rat islet beta-cells differentially express C-peptides derived from the genes coding for insulin I and II as well as a transfected human insulin gene. (1992) Mol Endocrinol 6: 299-307 (Added 2010-08-18 09:56:05.719642) |
| 1563584 | In 't Veld PA, Zhang F, Madsen OD, Klöppel G Islet amyloid polypeptide immunoreactivity in the human fetal pancreas. (1992) Diabetologia 35: 272-6 (Added 2010-08-18 09:56:05.715903) |
| 1406710 | Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. (1992) Mol Endocrinol 6: 1332-42 (Added 2010-08-18 09:56:05.712155) |
| Resource ID | Name | Contributed on | Primary Contributor |
|---|---|---|---|
| 266 | Polyclonal Rat IAPP raised in Rabbit | Jun 2, 2003 | Yes |
| 267 | Polyclonal Rat C-peptide 2 raised in Rabbit | Jun 2, 2003 | Yes |
| 268 | Polyclonal Rat C-peptide 1 raised in Rabbit | Jun 2, 2003 | Yes |
| 269 | Polyclonal Mouse C-peptide 1 raised in Rabbit | Jun 2, 2003 | Yes |
| 270 | Monoclonal Human Insulin raised in Mouse | Jul 2, 2003 | Yes |
| 271 | Polyclonal Rat PDX1 raised in Rabbit | Jul 2, 2003 | Yes |
| 272 | Polyclonal Rat PDX1 raised in Rabbit | Jul 2, 2003 | Yes |
| 273 | Polyclonal Rat Nkx6.1 raised in Rabbit | Jul 2, 2003 | Yes |
| 275 | Polyclonal Human ghrelin raised in Goat | Sep 22, 2003 | Yes |
| 276 | Polyclonal Mouse Pax6 raised in Rabbit | Sep 22, 2003 | Yes |
| 277 | Polyclonal Human b-catenin raised in Goat | Sep 22, 2003 | Yes |
| 278 | Monoclonal Mouse smooth muscle actin raised in Mouse | Sep 22, 2003 | Yes |
| 279 | Polyclonal Human amylase raised in Rabbit | Sep 22, 2003 | Yes |
| 280 | Polyclonal Human c-myc raised in Rabbit | Sep 23, 2003 | Yes |
| 281 | Polyclonal Rat Glut-2 raised in Rabbit | Sep 23, 2003 | Yes |
| 282 | Polyclonal bovine Carboxypeptidase A raised in Rabbit | Sep 23, 2003 | Yes |
| 283 | Polyclonal Human Chromogranin A raised in Rabbit | Sep 23, 2003 | Yes |
| 284 | Monoclonal Human Chromogranin A raised in Mouse | Sep 23, 2003 | Yes |
| 285 | Monoclonal Human Cytokeratin 7 raised in Mouse | Sep 23, 2003 | Yes |
| 286 | Monoclonal Human PECAM-1 raised in Mouse | Sep 23, 2003 | Yes |
| 287 | Polyclonal Aequorea victoria Green Fluorescent Protein raised in Rabbit | Sep 23, 2003 | Yes |
| 288 | Monoclonal Chicken Nkx2.2 raised in Mouse | Sep 25, 2003 | Yes |
| 289 | Polyclonal Rat ghrelin raised in Rabbit | Sep 25, 2003 | Yes |
| 290 | Monoclonal Chicken Islet-1 raised in Mouse | Sep 26, 2003 | Yes |
| 294 | Polyclonal Mouse PDX1 raised in Chicken | May 6, 2004 | Yes |
| 295 | Monoclonal Human Glucagon raised in Mouse | May 28, 2004 | Yes |
| 296 | Monoclonal Human Somatostatin raised in Mouse | May 28, 2004 | Yes |
| 297 | Monoclonal Rat Pancreatic Ducts raised in Mouse | Jun 30, 2004 | Yes |
| 298 | Monoclonal Rat Pancreatic Ducts raised in Mouse | Jul 1, 2004 | Yes |
| 299 | Monoclonal Rat Islet Delta Cells raised in Rat | Jul 1, 2004 | Yes |
| 300 | Monoclonal Rat Pancreatic Ducts raised in Rat | Jul 1, 2004 | Yes |
| 301 | Monoclonal Human Pro-Insulin raised in Mouse | Jul 1, 2004 | Yes |
| 302 | Polyclonal Mouse Ngn3 raised in Rabbit | Jul 1, 2004 | Yes |
| 303 | Polyclonal Mouse Ngn3 raised in Rabbit | Jul 1, 2004 | Yes |
| 304 | Monoclonal Mouse Ngn3 raised in Mouse | Jul 1, 2004 | Yes |
| 305 | Monoclonal Mouse Ngn3 raised in Mouse | Jul 1, 2004 | Yes |
| 307 | Monoclonal Rat Nkx6.1 raised in Mouse | Sep 24, 2004 | Yes |
| 308 | Monoclonal Rat Nkx6.1 raised in Mouse | Sep 27, 2004 | Yes |
| 309 | Monoclonal Rat Nkx6.1 raised in Mouse | Sep 27, 2004 | Yes |
| 310 | Monoclonal Rat Nkx6.1 raised in Mouse | Sep 27, 2004 | Yes |
| 312 | Polyclonal Mouse PDX1 raised in Goat | Nov 24, 2004 | Yes |
| 313 | Polyclonal Mouse PDX1 raised in Guinea Pig | Nov 24, 2004 | Yes |
| 314 | Polyclonal Human ghrelin raised in Rabbit | Dec 17, 2004 | Yes |
| 315 | Polyclonal Human ghrelin raised in Rabbit | Dec 17, 2004 | Yes |
| 316 | Monoclonal Rat PDX1 raised in Mouse | Jan 24, 2005 | Yes |
| 317 | Monoclonal Rat PDX1 raised in Mouse | Aug 5, 2005 | Yes |
| 318 | Monoclonal Rat PDX1 raised in Mouse | Aug 5, 2005 | Yes |
| 324 | Polyclonal Human Sox17 raised in Rabbit | Jun 12, 2006 | Yes |
| 325 | Polyclonal Human Sox17 raised in Rabbit | Jun 12, 2006 | Yes |
| 331 | Polyclonal Human Sox17 raised in Goat | Mar 19, 2007 | Yes |
| 332 | Polyclonal Mouse Shh raised in Goat | Apr 11, 2007 | Yes |
| 333 | Polyclonal E. coli beta Galactosidase raised in Chicken | Apr 11, 2007 | Yes |
| 334 | Monoclonal Aequorea victoria Green Fluorescent Protein raised in Mouse | Apr 11, 2007 | Yes |
| 335 | Polyclonal Mouse Ptf1a raised in Rabbit | Aug 29, 2007 | Yes |
| 336 | Polyclonal Mouse IA1 (Insm-1) raised in Rabbit | Aug 29, 2007 | Yes |
| 346 | Polyclonal Human T (Brachyury) raised in Goat | Apr 9, 2008 | Yes |
| 347 | Polyclonal Mouse Laminin raised in Rabbit | Apr 29, 2008 | Yes |
| 348 | Monoclonal Chicken Pax6 raised in Mouse | Apr 29, 2008 | Yes |
| 821 | Monoclonal Mouse BetaTC6 raised in Mouse | Feb 6, 2009 | Yes |
| 861 | Polyclonal Rat CART raised in Rabbit | Feb 9, 2009 | Yes |
| 883 | Monoclonal Rat CART raised in Mouse | Feb 9, 2009 | Yes |
| 961 | Monoclonal Mouse BetaTC6 raised in Mouse | Feb 11, 2009 | Yes |
| 962 | Monoclonal Mouse BetaTC6 raised in Mouse | Feb 11, 2009 | Yes |
| 964 | Monoclonal Human Disp2 raised in Mouse | Feb 11, 2009 | Yes |
| 965 | Monoclonal Human Disp2 raised in Mouse | Feb 11, 2009 | Yes |
| 966 | Polyclonal Mouse Lrp11 raised in Rabbit | Feb 11, 2009 | Yes |
| 967 | Polyclonal Mouse Sez6l2 raised in Rabbit | Feb 11, 2009 | Yes |
| 968 | Polyclonal Mouse Sez6l2 raised in Rabbit | Feb 11, 2009 | Yes |
| 969 | Polyclonal Human DDR1 raised in Goat | Feb 11, 2009 | Yes |
| 970 | Monoclonal Human DDR1 raised in Mouse | Feb 11, 2009 | Yes |
| 971 | Polyclonal Mouse Gpr39-1a raised in Rabbit | Feb 11, 2009 | Yes |
| 972 | Polyclonal Rat CART raised in Rabbit | Feb 11, 2009 | Yes |
| 974 | Monoclonal Rat CART raised in Mouse | Feb 11, 2009 | Yes |
| 1064 | Neurogenin3 deficiency and Embryonic Pancreatic Gene Expression | May 25, 2007 | Yes |
| 1161 | Polyclonal Mouse Carboxypeptidase A1 (CPA1) raised in Goat | Mar 9, 2009 | Yes |
| 1162 | Polyclonal Human Muc1 raised in Rabbit | Mar 9, 2009 | Yes |
| 1163 | Polyclonal Human Cleaved Notch1 raised in Rabbit | Mar 9, 2009 | Yes |
| 1164 | Polyclonal Human Jagged1 raised in Goat | Mar 9, 2009 | Yes |
| 2201 | Polyclonal Mouse DNER raised in Goat | Oct 13, 2009 | Yes |
| 2222 | Monoclonal Rat Shh raised in Mouse | Oct 14, 2009 | Yes |
| 2223 | Monoclonal Chicken Chick HNF3Beta raised in Mouse | Oct 14, 2009 | Yes |
| 2263 | Polyclonal Mouse Pax4 raised in Guinea Pig | Oct 20, 2009 | Yes |
| 2482 | Polyclonal Mouse Ngn3 raised in Goat | Nov 23, 2009 | Yes |
| 2922 | Wholemount Immunofluorescence | Feb 12, 2010 | Yes |
| 3022 | Polyclonal Mouse Irx2 raised in Rabbit | Mar 4, 2010 | Yes |
| 3023 | Polyclonal Mouse Arx raised in Rabbit | Mar 4, 2010 | Yes |
| 3102 | Polyclonal Mouse mArx raised in Guinea Pig | Apr 23, 2010 | Yes |
| 3185 | Monoclonal Human C-peptide raised in Rat | May 1, 2004 | Yes |
| 4040 | Polyclonal Human TSPAN7 raised in Rabbit | Nov 2, 2010 | Yes |
| 4041 | Monoclonal Human FXYD2 raised in Mouse | Nov 2, 2010 | Yes |
| 4047 | Polyclonal Mouse Sez6l2 raised in Rabbit | Jan 7, 2011 | Yes |
| 4048 | Polyclonal Human Lrp11 raised in Rabbit | Jan 7, 2011 | Yes |
| 4052 | Polyclonal Mouse Onecut1 raised in Guinea Pig | Mar 2, 2011 | Yes |
| 4113 | Polyclonal Enterobacteria phage P1 Cre raised in Guinea Pig | Jul 13, 2011 | Yes |
| 4128 | Monoclonal Mouse TMEM27 raised in Mouse | Sep 26, 2011 | Yes |
| 4129 | Polyclonal Human Ngn3 raised in Sheep | Sep 27, 2011 | Yes |
| 4130 | Monoclonal Mouse Pax4 raised in Mouse | Sep 27, 2011 | Yes |
| 4131 | Monoclonal Mouse Pax4 raised in Mouse | Sep 28, 2011 | Yes |
| 4132 | Monoclonal Mouse Pax4 raised in Mouse | Sep 28, 2011 | Yes |
| 4133 | Monoclonal Human CD142 raised in Mouse | Sep 28, 2011 | Yes |
| 4134 | Monoclonal Rat Beta cell, IC2 raised in Rat | Sep 29, 2011 | Yes |
| 4135 | Polyclonal Human CD-200 raised in Goat | Sep 29, 2011 | Yes |
| 4256 | Polyclonal Human HIP-14 ZDHHC17 raised in Rabbit | Mar 1, 2012 | Yes |
| 103 completed resources viewable | |||
