John Hutton - Investigator Profile
My laboratory has a long-standing interest in the molecular cell biology of insulin secretion and the biochemical composition and the process of formation of the insulin storage granule of the pancreatic islet. Many insulin granule proteins are autoantigens in type 1 diabetes (insulin, IA2, phogrin, CPH) and we have focused on the molecular targets of T-cell clones isolated from a new-onset type 1 humans and the NOD mouse experimental model. The granule proteins phogrin and IA2 have been extensively studied in this context and their peptide epitopes are presently being evaluated with regard to intramolecular and intermolecular epitope spreading in the disease and as novel therapeutic agents to abrogate diabetic autoimmunity.
Scientific Interests/Keywords
Molecular Cell Biology of Insulin Secretion
Publications
| Publication | Citation |
|---|---|
| 12688631 | Bright NA, Walters J, Wasmeier C, Hutton JC Targeting of a phogrin-green fluorescent protein chimaera to insulin (2002) Diabetes Metab 28: 3S29-36; discussion 3S108-12 (Added 2005-04-13 12:55:20) |
| 12191017 | Wasmeier C, Bright NA, Hutton JC The lumenal domain of the integral membrane protein phogrin mediates (2002) Traffic 3: 654-65 (Added 2005-04-13 12:55:23) |
| 11473031 | Kelemen K, Wegmann DR, Hutton JC T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the (2001) Diabetes 50: 1729-34 (Added 2005-04-13 12:55:15) |
| 11353772 | Wasmeier C, Hutton JC Secretagogue-dependent phosphorylation of the insulin granule membrane (2001) J Biol Chem 276: 31919-28 (Added 2005-04-13 12:55:18) |
| 11297555 | Martin CC, Bischof LJ, Bergman B, Hornbuckle LA, Hilliker C, Frigeri C, Wahl D, Svitek CA, Wong R, Goldman JK, Oeser JK, Lepretre F, Froguel P, O'Brien RM, Hutton JC Cloning and characterization of the human and rat islet-specific (2001) J Biol Chem 276: 25197-207 (Added 2005-04-13 12:50:56) |
| 11289059 | Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C, Hutton J, Eisenbarth GS, Pugliese A Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as (2001) Diabetes 50: 895-900 (Added 2005-04-13 13:03:30) |
| 11086294 | Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 (2001) J Comp Neurol 429: 127-43 (Added 2005-04-13 12:55:13) |
