Judith Furth-Lavi, MSc. - Affiliate Profile
In my research I focus on understanding the homeostatic mechanisms that control beta cell number. Glucose was shown to be the major regulator of beta cell replication in basal conditions and during regeneration after injury. In order to imitate the effect of glucose I use small glucokinase activating molecules and study their potential. The objectives in my study are:
Understanding the optimal dose/schedule/route of administration of such molecules.
Studying the relationship between the mitogenic and toxic/apoptotic effects of these molecules and whether can we separate between them?
Is there an optimal drug combination that maximizes the effects of such molecules on net replication (e.g GLP1R agonists)?
What is the detailed signaling cascade leading from glucose to cell cycle entry?
Diabetes, Beta cell, Proliferation, Apoptosis, Glucokinase Activators
|17452235||Landau Z, Wainstein J, Hanukoglu A, Tuval M, Lavie J, Glaser B Sulfonylurea-responsive diabetes in childhood. (2007) J Pediatr 150: 553-5 (Added 2012-04-03 06:30:41.490415)|
|15579781||Tornovsky S, Crane A, Cosgrove KE, Hussain K, Lavie J, Heyman M, Nesher Y, Kuchinski N, Ben-Shushan E, Shatz O, Nahari E, Potikha T, Zangen D, Tenenbaum-Rakover Y, de Vries L, Argente J, Gracia R, Landau H, Eliakim A, Lindley K, Dunne MJ, Aguilar-Bryan L, Glaser B Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity. (2004) J Clin Endocrinol Metab 89: 6224-34 (Added 2012-04-03 06:30:51.440167)|
|10973248||Bitner-Glindzicz M, Lindley KJ, Rutland P, Blaydon D, Smith VV, Milla PJ, Hussain K, Furth-Lavi J, Cosgrove KE, Shepherd RM, Barnes PD, O'Brien RE, Farndon PA, Sowden J, Liu XZ, Scanlan MJ, Malcolm S, Dunne MJ, Aynsley-Green A, Glaser B A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene. (2000) Nat Genet 26: 56-60 (Added 2012-03-13 06:32:31.08459)|
|10447255||Glaser B, Furth J, Stanley CA, Baker L, Thornton PS, Landau H, Permutt MA Intragenic single nucleotide polymorphism haplotype analysis of SUR1 mutations in familial hyperinsulinism. (1999) Hum Mutat 14: 23-9 (Added 2012-03-13 06:35:44.096134)|