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David Gifford, Ph.D

Professor of Computer Science & Engineering
Massachusetts Institute of Technology
Computer Science and Artificial Intelligence Laboratory

32 Vassar Street G-542
Cambridge, MA 02139
USA

p. (617)-253-6039
f. 617-253-7512
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David Gifford, Ph.D - Co-investigator Profile

We have developed engineered mouse stem cell lines and computational models of pancreatic development to gain insight into potential therapeutics for diabetes. Our stem cell work is identifying in vitro differentiation protocols to create pancreatic progenitors, and we are experimentally elucidating the molecular events that occur during the development of these progenitors using a variety of high-throughput technologies (RNA Seq, ChIP Seq, Mass Spectrometry). Data from these experiments are processed with computational methods developed by our laboratory to reveal biological mechanisms for further exploration.

Scientific Interests/Keywords

computational biology, computational genomics, genomics,

Professor of Computer Science & Engineering, Gifford Lab

Publication Citation
22081127 Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H Embryonic stem cell-based mapping of developmental transcriptional programs. (2011) Nat Methods 8: 1056-8 (Added 2012-03-30 16:38:09.673875)
21232103 Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, Gifford DK Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. (2011) Genome Biol 12: R2 (Added 2012-03-30 16:39:58.129885)
20413493 Dowell RD, Ryan O, Jansen A, Cheung D, Agarwala S, Danford T, Bernstein DA, Rolfe PA, Heisler LE, Chin B, Nislow C, Giaever G, Phillips PC, Fink GR, Gifford DK, Boone C Genotype to phenotype: a complex problem. (2010) Science 328: 469 (Added 2012-03-30 16:40:40.446689)
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