Stephen Miller, Ph.D.

Professor
Northwestern University
Microbiology

Dept. of Microbiology-Immunology, Northwestern Univ. Med. School, 303 E. Chicago Avenue
Chicago, IL 60611
USA

p. 1-312-503-7674
f. 1-312-503-1154
· email
· website

Stephen Miller, Ph.D. - Co-investigator Profile

Dr. Miller is an internationally recognized immunologist noted for his research on pathogenesis and regulation of autoimmune diseases. His work has significantly enhanced understanding of immune inflammatory processes underlying chronic autoimmune disease employing animal models of multiple sclerosis (MS) and Type 1 diabetes (T1D). He was the first to describe the contribution of epitope spreading to endogenous self tissue antigens in mediating chronic CNS damage in both autoimmune [experimental autoimmune encephalomyelitis (EAE)] and Theiler’s virus-induced demyelinating disease models of MS. His more recent work has shown that epitope spreading is also involved in the pathogenesis of T1D in NOD mice. He is also noted for his work describing the cellular and molecular mechanisms underlying initiation and progression of autoimmunity by infection-induced molecular mimicry, including the critical role of pathogen-induced innate immune signals in cross-activating autoreactive T cells. The most widely known aspect of Dr. Miller’s scientific career has focused on the study of the cellular and molecular mechanisms underlying treatment of established T cell-mediated autoimmune diseases using antigen-specific therapies, including regulatory T cells (Tregs), induction of immune tolerance to autoantigens via i.v. injection of apoptotic antigen-pulsed cells, and the use of costimulatory molecule blockade strategies. Dr. Miller has been continuously funded for >30 years, currently holding multiple grants from the NIH, the National Multiple Sclerosis Society, the Myelin Repair Foundation, the Juvenile Diabetes Research Foundation and the Food Allergy Association. He has published >325 scientific publications and trained multiple generations of scientists including mentoring 4 M.S. students, 29 Ph.D. students (5 current), and 42 Ph.D. and M.D. postdoctoral fellows (7 current).

Scientific Interests/Keywords

Immunoregulation, autoimmune disease, type 1 diabetes, mulitple sclerosis,experimental autoimmune encephalomyelitis, transplantation, tolerance, costimulatory molecule blockade

Publication	Citation
21751954	Getts DR, Shankar S, Chastain EM, Martin A, Getts MT, Wood K, Miller SD Current landscape for T-cell targeting in autoimmunity and transplantation. (2011) Immunotherapy 3: 853-70 (Added 2011-08-01 09:04:47.701551)
21749708	Adipue IA, Wilcox JT, King C, Rice CA, Shaum KM, Suard CM, Ten Brink E, Miller SD, McMahon EJ Characterization of a novel and spontaneous mouse model of inflammatory arthritis. (2011) Arthritis Res Ther 13: R114 (Added 2011-08-01 09:04:47.715729)
21696712	Podojil JR, Padval MV, Miller SD Combination treatment of mice with crx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis. (2011) Cell Immunol : (Added 2011-08-01 09:04:47.741191)
21684336	Banisadr G, Frederick TJ, Freitag C, Ren D, Jung H, Miller SD, Miller RJ The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter. (2011) Neurobiol Dis : (Added 2011-08-01 09:04:47.752187)
21494618	Duncan DS, Miller SD CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. (2011) PLoS One 6: e18548 (Added 2011-08-01 09:04:47.763193)
21458857	Kheradmand T, Wang S, Gibly RF, Zhang X, Holland S, Tasch J, Graham JG, Kaufman DB, Miller SD, Shea LD, Luo X Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions. (2011) Biomaterials 32: 4517-24 (Added 2011-08-01 09:04:47.773168)
21315129	Ekong UD, Luo X, Yu M, Wang D, Miller SD, O'Gorman MR Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients. (2011) Hum Immunol 72: 392-7 (Added 2011-08-01 09:05:23.868441)
21273044	Richards MH, Getts MT, Podojil JR, Jin YH, Kim BS, Miller SD Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS. (2011) J Autoimmun 36: 142-54 (Added 2011-08-01 09:05:23.880257)
20940325	Dogan RN, Long N, Forde E, Dennis K, Kohm AP, Miller SD, Karpus WJ CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function. (2011) J Leukoc Biol 89: 93-104 (Added 2011-08-01 09:05:23.890228)
20935511	Getts DR, Getts MT, McCarthy DP, Chastain EM, Miller SD Have we overestimated the benefit of human(ized) antibodies? () MAbs 2: 682-94 (Added 2011-08-01 09:05:23.899759)
20851998	Traka M, Arasi K, Avila RL, Podojil JR, Christakos A, Miller SD, Soliven B, Popko B A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination. (2010) Brain 133: 3017-29 (Added 2011-08-01 09:06:07.80001)
20713889	Martin AJ, McCarthy D, Waltenbaugh C, Goings G, Luo X, Miller SD Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation. (2010) J Immunol 185: 3326-36 (Added 2011-08-01 09:06:07.812525)
20637861	Chastain EM, Duncan DS, Rodgers JM, Miller SD The role of antigen presenting cells in multiple sclerosis. (2011) Biochim Biophys Acta 1812: 265-74 (Added 2011-08-01 09:06:07.823502)
20626386	Pothoven KL, Kheradmand T, Yang Q, Houlihan JL, Zhang H, Degutes M, Miller SD, Luo X Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation. (2010) Am J Transplant 10: 1774-84 (Added 2011-08-01 09:06:07.83467)
20574004	Gris D, Ye Z, Iocca HA, Wen H, Craven RR, Gris P, Huang M, Schneider M, Miller SD, Ting JP NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. (2010) J Immunol 185: 974-81 (Added 2011-08-01 09:06:07.845389)
20538350	Jin YH, Hou W, Kim SJ, Fuller AC, Kang B, Goings G, Miller SD, Kim BS Type I interferon signals control Theiler's virus infection site, cellular infiltration and T cell stimulation in the CNS. (2010) J Neuroimmunol 226: 27-37 (Added 2011-08-01 09:06:07.855916)
20483764	Zhang H, Podojil JR, Chang J, Luo X, Miller SD TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis. (2010) J Immunol 184: 6629-36 (Added 2011-08-01 09:06:51.651674)
20476952	Schreiner B, Bailey SL, Miller SD T-cell response dynamics in animal models of multiple sclerosis: implications for immunotherapies. (2007) Expert Rev Clin Immunol 3: 57-72 (Added 2011-08-01 09:10:21.355748)
20415846	Getts MT, Miller SD 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: triggering of autoimmune diseases by infections. (2010) Clin Exp Immunol 160: 15-21 (Added 2011-08-01 09:06:51.663241)
20412759	Luo X, Herold KC, Miller SD Immunotherapy of type 1 diabetes: where are we and where should we be going? (2010) Immunity 32: 488-99 (Added 2011-08-01 09:06:51.674293)
20381109	Getts MT, Richards MH, Miller SD A critical role for virus-specific CD8(+) CTLs in protection from Theiler's virus-induced demyelination in disease-susceptible SJL mice. (2010) Virology 402: 102-11 (Added 2011-08-01 09:06:51.684187)
20357912	Getts MT, Getts DR, Kohm AP, Miller SD Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis. (2008) Therapy 5: 631-640 (Added 2011-08-01 09:08:49.769935)
20346771	Rodgers JM, Zhou L, Miller SD Act1, scene brain: astrocytes play a lead role. (2010) Immunity 32: 302-4 (Added 2011-08-01 09:06:51.693277)
20143314	Miller SD, Karpus WJ, Davidson TS Experimental autoimmune encephalomyelitis in the mouse. (2010) Curr Protoc Immunol Chapter 15: Unit 15.1 (Added 2011-08-01 09:06:51.70315)
19915620	Martin AJ, Zhou L, Miller SD MicroRNA--managing the TH-17 inflammatory response. (2009) Nat Immunol 10: 1229-31 (Added 2011-08-01 09:06:51.712345)
19426232	Podojil JR, Miller SD Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. (2009) Immunol Rev 229: 337-55 (Added 2011-08-01 09:07:31.363801)
19380818	Olson JK, Miller SD The innate immune response affects the development of the autoimmune response in Theiler's virus-induced demyelinating disease. (2009) J Immunol 182: 5712-22 (Added 2011-08-01 09:07:31.37607)
19319143	Münz C, Lünemann JD, Getts MT, Miller SD Antiviral immune responses: triggers of or triggered by autoimmunity? (2009) Nat Rev Immunol 9: 246-58 (Added 2011-08-01 09:07:31.386624)
19199938	Blink SE, Miller SD The contribution of gammadelta T cells to the pathogenesis of EAE and MS. (2009) Curr Mol Med 9: 15-22 (Added 2011-08-01 09:07:31.396587)
19191336	Bai L, Lennon DP, Eaton V, Maier K, Caplan AI, Miller SD, Miller RH Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. (2009) Glia 57: 1192-203 (Added 2011-08-01 09:07:31.406763)
19130025	Turley DM, Miller SD Prospects for antigen-specific tolerance based therapies for the treatment of multiple sclerosis. (2010) Results Probl Cell Differ 51: 217-35 (Added 2011-08-01 09:08:07.277784)
19124719	Podojil JR, Miller SD Cross-linking of CD80 on CD4+ T cells activates a calcium-dependent signaling pathway. (2009) J Immunol 182: 766-73 (Added 2011-08-01 09:08:07.289668)
19076824	Ercolini AM, Miller SD The role of infections in autoimmune disease. (2009) Clin Exp Immunol 155: 1-15 (Added 2011-08-01 09:08:07.299928)
19065796	Podojil JR, Turley DM, Miller SD Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease. (2008) Adv Exp Med Biol 640: 234-51 (Added 2011-08-01 09:08:07.310349)
19017286	Ekong UD, Miller SD, O'Gorman MR In vitro assays of allosensitization. (2009) Pediatr Transplant 13: 25-34 (Added 2011-08-01 09:08:07.320679)
19008075	Greene MT, Ercolini AM, DeGutes M, Miller SD Differential induction of experimental autoimmune encephalomyelitis by myelin basic protein molecular mimics in mice humanized for HLA-DR2 and an MBP(85-99)-specific T cell receptor. (2008) J Autoimmun 31: 399-407 (Added 2011-08-01 09:08:07.331101)
18922161	Goings GE, Greisman A, James RE, Abram LK, Begolka WS, Miller SD, Szele FG Hematopoietic cell activation in the subventricular zone after Theiler's virus infection. (2008) J Neuroinflammation 5: 44 (Added 2011-08-01 09:08:07.340853)
18825752	Schreiner B, Bailey SL, Shin T, Chen L, Miller SD PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE. (2008) Eur J Immunol 38: 2706-17 (Added 2011-08-01 09:08:07.350871)
18802066	Zhang H, Podojil JR, Luo X, Miller SD Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. (2008) J Immunol 181: 4638-47 (Added 2011-08-01 09:08:07.361257)
18796615	Luo X, Pothoven KL, McCarthy D, DeGutes M, Martin A, Getts DR, Xia G, He J, Zhang X, Kaufman DB, Miller SD ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms. (2008) Proc Natl Acad Sci U S A 105: 14527-32 (Added 2011-08-01 09:08:49.756853)
18516496	Nair A, Frederick TJ, Miller SD Astrocytes in multiple sclerosis: a product of their environment. (2008) Cell Mol Life Sci 65: 2702-20 (Added 2011-08-01 09:08:49.781238)
18490738	Cannon JL, Collins A, Mody PD, Balachandran D, Henriksen KJ, Smith CE, Tong J, Clay BS, Miller SD, Sperling AI CD43 regulates Th2 differentiation and inflammation. (2008) J Immunol 180: 7385-93 (Added 2011-08-01 09:08:49.792331)
18453561	Bailey-Bucktrout SL, Caulkins SC, Goings G, Fischer JA, Dzionek A, Miller SD Cutting edge: central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis. (2008) J Immunol 180: 6457-61 (Added 2011-08-01 09:08:49.80281)
18432984	Miller SD, Karpus WJ Experimental autoimmune encephalomyelitis in the mouse. (2007) Curr Protoc Immunol Chapter 15: Unit 15.1 (Added 2011-08-01 09:08:49.813972)
18289626	Carpentier PA, Getts MT, Miller SD Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease. (2008) Virology 375: 24-36 (Added 2011-08-01 09:08:49.825294)
17982050	Ercolini AM, Miller SD Molecular mimics can induce novel self peptide-reactive CD4+ T cell clonotypes in autoimmune disease. (2007) J Immunol 179: 6604-12 (Added 2011-08-01 09:09:26.077824)
17920811	Carpentier PA, Duncan DS, Miller SD Glial toll-like receptor signaling in central nervous system infection and autoimmunity. (2008) Brain Behav Immun 22: 140-7 (Added 2011-08-01 09:09:26.090835)
17690713	Miller SD, Turley DM, Podojil JR Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease. (2007) Nat Rev Immunol 7: 665-77 (Added 2011-08-01 09:09:26.102948)
17641656	Frederick TJ, Miller SD Arresting autoimmunity by blocking beta-arrestin 1. (2007) Nat Immunol 8: 791-2 (Added 2011-08-01 09:09:26.114332)
17428853	Getts MT, Kim BS, Miller SD Differential outcome of tolerance induction in naive versus activated Theiler's virus epitope-specific CD8+ cytotoxic T cells. (2007) J Virol 81: 6584-93 (Added 2011-08-01 09:10:21.24933)
17425418	Bennett JL, Elhofy A, Charo I, Miller SD, Dal Canto MC, Karpus WJ CCR2 regulates development of Theiler's murine encephalomyelitis virus-induced demyelinating disease. (2007) Viral Immunol 20: 19-33 (Added 2011-08-01 09:10:21.262567)
17376826	Miller SD, McMahon EJ, Schreiner B, Bailey SL Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. (2007) Ann N Y Acad Sci 1103: 179-91 (Added 2011-08-01 09:10:21.274848)
17376542	Ercolini AM, Ludovic Croxford J, Degutes M, Miller SD Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151: comparison of peptide priming in CFA vs. viral delivery. (2007) J Neuroimmunol 186: 5-18 (Added 2011-08-01 09:10:21.286437)
17314297	Balabanov R, Strand K, Goswami R, McMahon E, Begolka W, Miller SD, Popko B Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis. (2007) J Neurosci 27: 2013-24 (Added 2011-08-01 09:10:21.298827)
17289470	Smith CE, Miller SD Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities. (2006) J Autoimmun 27: 218-31 (Added 2011-08-01 09:10:21.310734)
17277126	Turley DM, Miller SD Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis. (2007) J Immunol 178: 2212-20 (Added 2011-08-01 09:10:21.323081)
17273557	Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. (2007) J Clin Invest 117: 448-56 (Added 2011-08-01 09:10:21.33428)
17206145	Bailey SL, Schreiner B, McMahon EJ, Miller SD CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. (2007) Nat Immunol 8: 172-80 (Added 2011-08-01 09:10:21.345293)
17091495	Carpentier PA, Williams BR, Miller SD Distinct roles of protein kinase R and toll-like receptor 3 in the activation of astrocytes by viral stimuli. (2007) Glia 55: 239-52 (Added 2011-08-01 09:11:02.731406)
16981179	Croxford JL, Ercolini AM, Degutes M, Miller SD Structural requirements for initiation of cross-reactivity and CNS autoimmunity with a PLP139-151 mimic peptide derived from murine hepatitis virus. (2006) Eur J Immunol 36: 2671-80 (Added 2011-08-01 09:11:02.743096)
16951693	Verda L, Luo K, Kim DA, Bronesky D, Kohm AP, Miller SD, Statkute L, Oyama Y, Burt RK Effect of hematopoietic growth factors on severity of experimental autoimmune encephalomyelitis. (2006) Bone Marrow Transplant 38: 453-60 (Added 2011-08-01 09:11:02.754027)
16920930	Podojil JR, Kohm AP, Miller SD CD4+ T cell expressed CD80 regulates central nervous system effector function and survival during experimental autoimmune encephalomyelitis. (2006) J Immunol 177: 2948-58 (Added 2011-08-01 09:11:02.765471)
16730862	McMahon EJ, Bailey SL, Miller SD CNS dendritic cells: critical participants in CNS inflammation? (2006) Neurochem Int 49: 195-203 (Added 2011-08-01 09:11:50.139028)
16517695	Kohm AP, McMahon JS, Podojil JR, Begolka WS, DeGutes M, Kasprowicz DJ, Ziegler SF, Miller SD Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells. (2006) J Immunol 176: 3301-5 (Added 2011-08-01 09:11:50.15969)
16517694	Ercolini AM, Miller SD Mechanisms of immunopathology in murine models of central nervous system demyelinating disease. (2006) J Immunol 176: 3293-8 (Added 2011-08-01 09:11:50.170266)
16374777	Plant SR, Wang Y, Vasseur S, Thrash JC, McMahon EJ, Bergstralh DT, Arnett HA, Miller SD, Carson MJ, Iovanna JL, Ting JP Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues. (2006) Glia 53: 529-37 (Added 2011-08-01 09:11:50.181636)
16323419	Olson JK, Ercolini AM, Miller SD A virus-induced molecular mimicry model of multiple sclerosis. (2005) Curr Top Microbiol Immunol 296: 39-53 (Added 2011-08-01 09:11:50.192208)
16318987	Kohm AP, Turley DM, Miller SD Targeting the TCR: T-cell receptor and peptide-specific tolerance-based strategies for restoring self-tolerance in CNS autoimmune disease. () Int Rev Immunol 24: 361-92 (Added 2011-08-01 09:11:50.202414)
16207246	Croxford JL, Wang K, Miller SD, Engman DM, Tyler KM Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression. (2005) Cell Microbiol 7: 1592-602 (Added 2011-08-01 09:12:30.948522)
16197809	Ercolini AM, Miller SD Role of immunologic cross-reactivity in neurological diseases. (2005) Neurol Res 27: 726-33 (Added 2011-08-01 09:12:30.959997)
16137665	Kohm AP, Podojil JR, Williams JS, McMahon JS, Miller SD CD28 regulates glucocorticoid-induced TNF receptor family-related gene expression on CD4+ T cells via IL-2-dependent mechanisms. (2005) Cell Immunol 235: 56-64 (Added 2011-08-01 09:12:30.96988)
15991363	Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. (2005) Nat Immunol 6: 680-8 (Added 2011-08-01 09:12:30.979871)
15983366	Smith CE, Eagar TN, Strominger JL, Miller SD Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. (2005) Proc Natl Acad Sci U S A 102: 9595-600 (Added 2011-08-01 09:12:30.989436)
15956599	Croxford JL, Olson JK, Anger HA, Miller SD Initiation and exacerbation of autoimmune demyelination of the central nervous system via virus-induced molecular mimicry: implications for the pathogenesis of multiple sclerosis. (2005) J Virol 79: 8581-90 (Added 2011-08-01 09:12:30.999327)
15853743	Howard LM, Kohm AP, Castaneda CL, Miller SD Therapeutic blockade of TCR signal transduction and co-stimulation in autoimmune disease. (2005) Curr Drug Targets Inflamm Allergy 4: 205-16 (Added 2011-08-01 09:13:00.272666)
15814673	Kohm AP, Williams JS, Bickford AL, McMahon JS, Chatenoud L, Bach JF, Bluestone JA, Miller SD Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. (2005) J Immunol 174: 4525-34 (Added 2011-08-01 09:13:00.285742)
15735651	McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. (2005) Nat Med 11: 335-9 (Added 2011-08-01 09:13:00.29568)
15634913	Croxford JL, Anger HA, Miller SD Viral delivery of an epitope from Haemophilus influenzae induces central nervous system autoimmune disease by molecular mimicry. (2005) J Immunol 174: 907-17 (Added 2011-08-01 09:13:00.306231)

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