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David Serreze, BS, MS, PhD
Professor
The Jackson Laboratory
N/A
The Jackson Laboratory
Bar Harbor,
Maine
04609
US
p. 207-288-6403
f. 207-288-6053
· email
David Serreze, BS, MS, PhD - Co-investigator Profile
My research is focused on the generation and utilization of mouse models to dissect the genetic basis for the autoreactive T-lymphocytes responses underlying the development of type 1 diabetes (T1D). It is my hope that these efforts ultimately result in the development of intervention approaches that will prevent progression to overt T1D in humans deemed to be at high future disease risk.
Scientific Interests/Keywords
type I diabetes, autoimmunity, mouse models, immune therapy
Professor, Serreze Lab
| Publication | Citation |
|---|---|
| 21357538 | Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV Testing the role of P2X(7) receptors in the development of type 1 diabetes in nonobese diabetic mice. (2011) J Immunol 186: 4278-84 (Added 2011-06-09 09:32:10.171264) |
| 21346176 | Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. (2011) Diabetes 60: 1229-36 (Added 2011-06-09 09:32:10.215569) |
| 21307079 | Driver JP, Chen YG, Zhang W, Asrat S, Serreze DV Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. (2011) Diabetes 60: 1354-9 (Added 2011-06-09 09:32:10.223068) |
| 20012396 | Serreze DV, Niens M, Kulik J, Dilorenzo TP Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans. (2010) Methods Mol Biol 602: 119-34 (Added 2011-06-09 09:32:10.231813) |
| 19903740 | Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. (2010) Diabetes 59: 423-32 (Added 2011-06-09 09:32:10.240597) |
| 18776136 | Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. (2008) Diabetes 57: 3273-80 (Added 2011-06-09 09:35:59.70382) |
| 18430797 | Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. (2008) Proc Natl Acad Sci U S A 105: 6374-9 (Added 2011-06-09 09:35:59.716733) |
| 18292549 | Serreze DV, Choisy-Rossi CM, Grier AE, Holl TM, Chapman HD, Gahagan JR, Osborne MA, Zhang W, King BL, Brown A, Roopenian D, Marron MP Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice. (2008) J Immunol 180: 3250-9 (Added 2011-06-09 09:35:59.728928) |
| 17620420 | Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. (2007) Diabetes 56: 2551-60 (Added 2011-06-09 09:35:59.740144) |
| 16920929 | Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. (2006) J Immunol 177: 2939-47 (Added 2011-06-09 09:37:21.044479) |
| 16493087 | Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. (2006) J Immunol 176: 3257-65 (Added 2011-06-09 09:37:21.056331) |
| 15661873 | Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. (2005) J Immunol 174: 1196-204 (Added 2011-06-09 09:38:04.414276) |
| 12815107 | Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. (2003) Proc Natl Acad Sci U S A 100: 8384-8 (Added 2011-06-09 09:39:46.919207) |
| 12498815 | DiLorenzo TP, Lieberman SM, Takaki T, Honda S, Chapman HD, Santamaria P, Serreze DV, Nathenson SG During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. (2002) Clin Immunol 105: 332-41 (Added 2011-06-09 09:39:46.930828) |
| 10725754 | Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. (2000) J Immunol 164: 3913-8 (Added 2011-06-09 09:40:29.040058) |
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