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Donald Scott, PhD - Co-investigator Profile
Dr. Scott is an Associate Professor of Medicine in the Division of Endocrinology and Metabolism, with a joint appointment in the Department of Microbiology and Molecular Genetics. The research focus of Dr. Scott’s group is the nutritional regulation of cellular phenotype. His lab works on molecular mechanisms that coordinate how nutrients alter the regulation and expression of genes to change the phenotype of cells. The current focus of is work includes the roles that the glucose-sensing transcription factors ChREBP and c-Myc play in the regulation of beta cell and liver biology. |
Scientific Interests/Keywords
Not provided
Associate Professor, Scott Lab
| Publication | Citation |
|---|---|
| 20668294 | Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. (2010) Diabetes 59: 1926-36 (Added 2011-05-19 14:13:43.605727) |
| 20382893 | Zhang P, Metukuri MR, Bindom SM, Prochownik EV, O'Doherty RM, Scott DK c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes. (2010) Mol Endocrinol 24: 1274-86 (Added 2010-08-25 12:00:05.221486) |
| 19934001 | Huang W, Metlakunta A, Dedousis N, Zhang P, Sipula I, Dube JJ, Scott DK, O'Doherty RM Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. (2010) Diabetes 59: 347-57 (Added 2010-08-25 12:00:05.225735) |
| 19631660 | Burke SJ, Collier JJ, Scott DK cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter. (2009) J Mol Biol 392: 578-88 (Added 2010-08-25 12:00:05.230213) |
| 19406844 | Burke SJ, Collier JJ, Scott DK cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP. (2009) FASEB J 23: 2855-65 (Added 2010-08-25 12:00:05.234414) |
| 18650366 | Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. (2008) Diabetes 57: 3056-68 (Added 2011-05-19 14:14:36.009022) |
| 18474611 | Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB, Vasseur-Cognet M The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells. (2008) Mol Cell Biol 28: 4588-97 (Added 2010-08-25 12:00:50.64229) |
| 17400928 | Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A Glucose infusion in mice: a new model to induce beta-cell replication. (2007) Diabetes 56: 1792-801 (Added 2010-08-25 12:00:50.651139) |
| 17341548 | Collier JJ, Zhang P, Pedersen KB, Burke SJ, Haycock JW, Scott DK c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells. (2007) Am J Physiol Endocrinol Metab 293: E48-56 (Added 2010-08-25 12:00:50.655204) |
| 17106062 | Pedersen KB, Zhang P, Doumen C, Charbonnet M, Lu D, Newgard CB, Haycock JW, Lange AJ, Scott DK The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. (2007) Am J Physiol Endocrinol Metab 292: E788-801 (Added 2010-08-25 12:00:50.659101) |
| 14694084 | Collier JJ, Scott DK Sweet changes: glucose homeostasis can be altered by manipulating genes controlling hepatic glucose metabolism. (2004) Mol Endocrinol 18: 1051-63 (Added 2010-08-25 12:01:37.122056) |
| 14674713 | Scott DK, Collier JJ, Doan TT, Bunnell AS, Daniels MC, Eckert DT, O'Doherty RM A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression. (2003) Mol Cell Biochem 254: 327-37 (Added 2010-08-25 12:01:37.125959) |
| 12480946 | Collier JJ, Doan TT, Daniels MC, Schurr JR, Kolls JK, Scott DK c-Myc is required for the glucose-mediated induction of metabolic enzyme genes. (2003) J Biol Chem 278: 6588-95 (Added 2010-08-25 12:01:37.133587) |
| 9727036 | Scott DK, O'Doherty RM, Stafford JM, Newgard CB, Granner DK The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. (1998) J Biol Chem 273: 24145-51 (Added 2010-08-25 12:01:54.744776) |
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