Jorge Ferrer, M.D., Ph.D.

Professor, Chair in Genetics and Medicine, Section head
Imperial College London
Medicine

Imperial Centre for Translational and Experimental Medicine, Room 530, Du Cane Road
London, W12 0NN
United Kingdom

p. +442075940968
· email
· website

Jorge Ferrer, M.D., Ph.D. - Investigator Profile

Our lab is interested in understanding the epigenetic and genomic regulatory mechanisms that control the differentiation and function of pancreatic insulin-producing ß-cells. We use this information to gain new insights into the molecular defects that cause different forms of diabetes. This knowledge is also very relevant for the generation of new insulin-producing cells for replacement therapies in Type 1 diabetes.

Scientific Interests/Keywords

Genomic and epigenetic regulation of pancreatic beta cells, pancreas regeneration, genetic mechanisms of diabetes

Group Leader, Senior Specialist, Ferrer Lab

Publications
Contributions

Publication	Citation
23271347	van Arensbergen J, García-Hurtado J, Maestro MA, Correa-Tapia M, Rutter GA, Vidal M, Ferrer J Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells. (2013) Genes Dev 27: 52-63 (Added 2013-03-16 15:30:59.450909)
23040067	Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakić N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. (2012) Cell Metab 16: 435-48 (Added 2013-03-29 08:06:27.832103)
23006323	Rodríguez-Seguí S, Akerman I, Ferrer J GATA believe it: new essential regulators of pancreas development. (2012) J Clin Invest 122: 3469-71 (Added 2013-03-16 15:31:38.406556)
22158542	Lango Allen H, Flanagan SE, Shaw-Smith C, De Franco E, Akerman I, Caswell R, International Pancreatic Agenesis Consortium, Ferrer J, Hattersley AT, Ellard S GATA6 haploinsufficiency causes pancreatic agenesis in humans. (2012) Nat Genet 44: 20-2 (Added 2013-03-16 15:32:01.346623)
21913087	Nammo T, Rodríguez-Seguí SA, Ferrer J Mapping open chromatin with formaldehyde-assisted isolation of regulatory elements. (2011) Methods Mol Biol 791: 287-96 (Added 2013-03-16 15:32:46.866708)
21497752	Akerman I, van Arensbergen J, Ferrer J Removing the brakes on cell identity. (2011) Dev Cell 20: 411-2 (Added 2013-03-16 15:33:05.821907)
21459319	Ferrer J Glucose as a mitogenic hormone. (2011) Cell Metab 13: 357-8 (Added 2013-03-16 15:33:21.015438)
20523905	Boj SF, Petrov D, Ferrer J Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha. (2010) PLoS Genet 6: e1000970 (Added 2010-07-21 12:37:45.845505)
20395405	van Arensbergen J, García-Hurtado J, Moran I, Maestro MA, Xu X, Van de Casteele M, Skoudy AL, Palassini M, Heimberg H, Ferrer J Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. (2010) Genome Res 20: 722-32 (Added 2011-04-19 12:44:37.68382)
20133622	Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, del Castillo G, Deeb A, Deiss D, Fernandez JM, Godbole K, Hussain K, O'Connell M, Klupa T, Kolouskova S, Mohsin F, Perlman K, Sumnik Z, Rial JM, Ugarte E, Vasanthi T, Neonatal Diabetes International Group, Johnstone K, Flanagan SE, Martínez R, Castaño C, Patch AM, Fernández-Rebollo E, Raile K, Morgan N, Harries LW, Castaño L, Ellard S, Ferrer J, Perez de Nanclares G, Hattersley AT Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. (2010) Proc Natl Acad Sci U S A 107: 3105-10 (Added 2011-03-15 13:17:14.682655)
20118932	Gaulton KJ, Nammo T, Pasquali L, Simon JM, Giresi PG, Fogarty MP, Panhuis TM, Mieczkowski P, Secchi A, Bosco D, Berney T, Montanya E, Mohlke KL, Lieb JD, Ferrer J A map of open chromatin in human pancreatic islets. (2010) Nat Genet 42: 255-9 (Added 2011-08-02 10:37:15.085368)
20059954	Solar M, Cardalda C, Houbracken I, Martín M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. (2009) Dev Cell 17: 849-60 (Added 2010-08-30 11:30:23.40283)
19656489	Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. (2009) Cell Metab 10: 110-8 (Added 2010-02-19 13:14:38.581655)
19289501	Servitja JM, Pignatelli M, Maestro MA, Cardalda C, Boj SF, Lozano J, Blanco E, Lafuente A, McCarthy MI, Sumoy L, Guigó R, Ferrer J Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. (2009) Mol Cell Biol 29: 2945-59 (Added 2010-02-19 13:14:38.58458)
19188435	Boj SF, Servitja JM, Martin D, Rios M, Talianidis I, Guigo R, Ferrer J Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans. (2009) Diabetes 58: 1245-53 (Added 2010-02-19 13:14:38.587642)
18497863	Luco RF, Maestro MA, Sadoni N, Zink D, Ferrer J Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets. (2008) PLoS Genet 4: e1000079 (Added 2010-02-19 13:14:38.59072)
17923767	Maestro MA, Cardalda C, Boj SF, Luco RF, Servitja JM, Ferrer J Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth. (2007) Endocr Dev 12: 33-45 (Added 2010-02-19 13:14:38.59379)
17407387	Pearson ER, Boj SF, Steele AM, Barrett T, Stals K, Shield JP, Ellard S, Ferrer J, Hattersley AT Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. (2007) PLoS Med 4: e118 (Added 2010-02-19 13:14:38.596823)
17404611	Ferrer J, Martín M, Servitja JM Putting pancreatic cell plasticity to the test. (2007) J Clin Invest 117: 859-62 (Added 2010-02-19 13:14:38.600011)
16873682	Luco RF, Maestro MA, del Pozo N, Philbrick WM, de la Ossa PP, Ferrer J A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious. (2006) Diabetes 55: 2202-11 (Added 2010-02-19 13:16:46.1161)
16511571	Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. (2006) EMBO J 25: 1344-52 (Added 2010-02-19 13:16:46.121803)
16472605	Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. (2006) Gastroenterology 130: 532-41 (Added 2010-02-19 13:16:46.124962)
15298336	Servitja JM, Ferrer J Transcriptional networks controlling pancreatic development and beta cell function. (2004) Diabetologia 47: 597-613 (Added 2010-02-19 13:16:46.128208)
14570708	Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas. (2003) Hum Mol Genet 12: 3307-14 (Added 2010-02-19 13:16:46.131363)

Resource ID	Name	Contributed on	Primary Contributor
4081	Chromatin immunoprecipitation of mouse pancreatic beta and acinar cells, embryonic stem cells, Pdx1-expressing endocrine progenitors and 10 other normal adult tissues	Apr 19, 2011	Yes
4082	Transcriptional profiling of mouse pancreatic beta-cells, embryonic stem cells and 10 other normal adult tissues	Apr 19, 2011	Yes
4119	Open chromatin in human pancreatic islets (FAIRE-seq) - Appendix	Aug 2, 2011	Yes
4181	LncRNA-HI1/ pTrip emGFP miR-shRNA-1	Jan 18, 2012
4182	LncRNA-HI1/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4183	LncRNA-HI1/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4184	LncRNA-HI1/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4185	LncRNA-HI12/ pTrip emGFP miR-shRNA-1	Jan 18, 2012
4186	LncRNA-HI12/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4187	LncRNA-HI12/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4188	LncRNA-HI12/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4189	LncRNA-HI15/ pTrip emGFP miR-shRNA-1	Jan 18, 2012
4190	LncRNA-HI15/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4191	LncRNA-HI15/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4192	LncRNA-HI15/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4193	LncRNA-HI25/ pTrip emGFP miR-shRNA-1	Jan 18, 2012
4194	LncRNA-HI25/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4195	LncRNA-HI25/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4196	LncRNA-HI25/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4197	LncRNA-HI30/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4198	LncRNA-HI30/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4199	LncRNA-HI41/ pTrip emGFP miR-shRNA-1	Jan 18, 2012
4200	LncRNA-HI41/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4201	LncRNA-HI41/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4202	LncRNA-HI41/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4203	LncRNA-HI42/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4204	LncRNA-HI45/ pTrip emGFP miR-shRNA-1	Jan 18, 2012
4205	LncRNA-HI45/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4206	LncRNA-HI45/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4207	LncRNA-HI60/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4208	LncRNA-HI60/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4209	LncRNA-HI60/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4210	LncRNA-HI62/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4211	LncRNA-HI62/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4212	LncRNA-HI62/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4213	LncRNA-HI63/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4214	LncRNA-HI63/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4215	LncRNA-HI63/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4216	LncRNA-HI65/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4217	LncRNA-HI70/ pTrip emGFP miR-shRNA-2	Jan 18, 2012
4218	LncRNA-HI71/ pTrip emGFP miR-shRNA-3	Jan 18, 2012
4219	LncRNA-HI71/ pTrip emGFP miR-shRNA-4	Jan 18, 2012
4242	Identification of Zebrafish linc RNAs with conservation to Human pancreatic enriched lncRNAs	Jan 23, 2012	Yes
4243	Isolation of Pancreatic Islets from Zebrafish	Jan 23, 2012	Yes
4544	Ferrer lncRNA manuscript - confidential	Sep 26, 2012	Yes
4557	Transcriptional and epigenetic high throughput sequencing of human and mouse pancreatic islet-cells	Nov 20, 2012	Yes
4583	A model of transcriptional ncRNA networks in islet-cell differentiation	Mar 29, 2013
47 completed resources viewable