Jacob Hald, Ph.D.
Hagedorn Research Institute
Niels Steensens Vej 1
Jacob Hald, Ph.D. - Affiliate Profile
The specific aims of my projects are to:
* Generate monoclonal antibodies directed against cell surface markers expressed by endoderm and/or endocrine cells at different stages of development.
* Characterize the tissue distribution, cell specificity and nature of antigens defined by endocrine-specific monoclonal antibodies
Specifically I am doing target validation on the developing and adult pancreas and on differentiated ES cells and cell lines to find and validate targets that can be used for generating monoclonal antibodies.
antibody, beta-cell, FACS, hES, pancreas
|20558340||Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels. (2010) Eur J Histochem 54: e19 (Added 2013-01-08 04:10:54.601995)|
|19213833||Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. (2009) Endocrinology 150: 2577-85 (Added 2009-12-18 14:23:15.406255)|
|18347078||Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. (2008) J Histochem Cytochem 56: 587-95 (Added 2009-12-18 14:22:38.232312)|
|17881611||Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J An illustrated review of early pancreas development in the mouse. (2007) Endocr Rev 28: 685-705 (Added 2009-12-18 14:22:38.272302)|
|17555568||Ahnfelt-Rønne J, Hald J, Bødker A, Yassin H, Serup P, Hecksher-Sørensen J Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. (2007) BMC Dev Biol 7: 63 (Added 2009-12-18 14:22:38.275102)|
|17478445||Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. (2007) J Histochem Cytochem 55: 925-30 (Added 2009-12-18 14:22:38.277924)|
|12921743||Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. (2003) Dev Biol 260: 426-37 (Added 2013-05-07 05:22:01.314552)|
|10615124||Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD Control of endodermal endocrine development by Hes-1. (2000) Nat Genet 24: 36-44 (Added 2009-12-18 14:22:38.283405)|