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Andrew Stewart, M.D.

Director, Diabetes, Obesity and Metabolism Institute; Professor of Medicine
Mount Sinai School of Medicine
Medicine - Division of Endocrinology

Mount Sinai School of Medicine, Atran 4-5, Room 402, One Gustave L. Levy Place, Box 1152
New York, NY 10029
USA

p. 212-241-7680
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Andrew Stewart, M.D. - Investigator Profile

Andrew Fyfe Stewart, M.D.

Irene and Arthur M. Fishberg Professor, Mount Sinai School of Medicine, New York, NY.  

Director, Diabetes, Metabolism and Obesity Institute, Mount Sinai School of Medicine, NY, NY

Dr. Andrew Stewart has led a career devoted to patient care and basic and clinical research in endocrinology and diabetes research for over 30 years.  He served as the Chief, Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine from 1997 to 2012.  He also served as the Co-Director of the University of Pittsburgh Diabetes Institute. He assumed his current positions at Mount Sinai in November 2012.

Dr. Stewart''s research focuses on three areas.  The first is the regulation of calcium and bone metabolism.  He and his group discovered parathyroid hormone-related protein (PTHrP), a new hormone that is currently showing promise as a pure anabolic skeletal agent for the treatment of osteoporosis.  He also has an interest in vascular cell biology and arterial re-stenosis following angioplasty and coronary stenting.  Finally, he currently is spending most of his time understanding and developing novel means for inducing the replication and regeneration of pancreatic beta cells.  His lab was the first to demonstrate that growth factors could drive beta cell replication, and also improve glucose control in living animals.  He was also the first to carefully define cell cycle control in the rodent and human beta cell, and is actively involved in understanding why beta cells normally do not replicate, and how they can be induced to replicate.  This work is the subject of invited symposia at both the American Diabetes Association (ADA), the European Islet Study Group (ISG), and the European Association for the Study of Diabetes (EASD). 

Dr. Stewart received his bachelor''s degree from Trinity College in Hartford, Connecticut and his M.D. from Columbia University, College of Physicians and Surgeons, New York, New York.  He served as a fellow in Endocrinology and Metabolism at Yale University School of Medicine in Connecticut.

Prior to moving to the University of Pittsburgh in 1997, Dr. Stewart was tenured professor at Yale University School of Medicine, where he served for the preceding 19 years.  He has received numerous honors, including Councilor of both the Endocrine Society as well as the American Society for Bone and Mineral Research (ASBMR); Secretary-Treasurer of the Endocrine Society, and Chair of the Research Policy Committee for the ADA.  He has given numerous lectureships and invited symposia at Johns Hopkins, the University of Pennsylvania, the National Institutes of Health, Yale University, Massachusetts General Hospital, UC San Francisco, and many others, as well as at the Annual Meetings of the Endocrine Society, the American Diabetes Association, and the American Society for Bone and Mineral Research.  In addition, he is regularly recognized as one of the Best Doctors in America.  He has published 230 scientific papers, with many in journals of the highest quality, including the Proceedings of the National Academy of Sciences, the New England Journal of Medicine, and Science. Dr. Stewart is the continuous recipient of numerous research grants for the past 30 years. He currently has strong support from the NIH, and the American Diabetes Association, the JRDF and other agencies.  He was the 2008 recipient of the Endocrine Society''s Gerald Aurbach Award for outstanding scientific achievement. He was the Scientific Sessions Committee Chair for the American Diabetes Association Annnual Meetings in 2010 and 2011.

Scientific Interests/Keywords

Cell Cycle Control

Human Beta Cells

Chief of Division of Endocrinology, Professor of Medicine, Stewart Lab

Click to view the profile for Nathalie Fiaschi-Taesch, PhD.
Click to view the profile for Karen Takane, PhD.
Publication Citation
23493571 Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human Beta Cell Replication: A Revised Model of Human Beta Cell G1/S Control. (2013) Diabetes : (Added 2013-03-21 07:17:10.894585)
23493570 Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF A Human Pancreatic Beta Cell G1/S Molecule Cell Cycle Atlas. (2013) Diabetes : (Added 2013-03-21 07:17:09.762232)
22798294 Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets. (2012) Mol Endocrinol 26: 1590-602 (Added 2013-03-22 09:07:17.306322)
22751699 Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF Human β-cell proliferation and intracellular signaling: driving in the dark without a road map. (2012) Diabetes 61: 2205-13 (Added 2013-03-13 17:03:23.653268)
22586588 Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. (2012) Diabetes 61: 2004-15 (Added 2013-03-22 09:06:45.422999)
22210317 Takane KK, Kleinberger JW, Salim FG, Fiaschi-Taesch NM, Stewart AF Regulated and reversible induction of adult human β-cell replication. (2012) Diabetes 61: 418-24 (Added 2012-04-16 14:07:38.846687)
22156222 Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK A human islet cell culture system for high-throughput screening. (2012) J Biomol Screen 17: 509-18 (Added 2012-04-16 14:08:55.303305)
21885567 Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, Scott DK, Stewart AF cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. (2011) Mol Endocrinol 25: 1760-72 (Added 2012-04-10 16:36:01.438444)
21800111 Williams K, Abanquah D, Joshi-Gokhale S, Otero A, Lin H, Guthalu NK, Zhang X, Mozar A, Bisello A, Stewart AF, Garcia-Ocaña A, Vasavada RC Systemic and acute administration of parathyroid hormone-related peptide(1-36) stimulates endogenous beta cell proliferation while preserving function in adult mice. (2011) Diabetologia 54: 2867-77 (Added 2012-03-15 17:56:49.889019)
20980460 Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. (2011) Diabetes 60: 525-36 (Added 2012-01-23 21:19:51.539701)
20936253 Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. (2011) Diabetologia 54: 572-82 (Added 2011-09-14 09:32:21.545794)
20876711 Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. (2010) Diabetes 59: 3131-8 (Added 2012-01-23 21:19:56.350287)
20668294 Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. (2010) Diabetes 59: 1926-36 (Added 2011-05-19 14:13:43.605727)
19509021 Harb G, Vasavada RC, Cobrinik D, Stewart AF The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells. (2009) Diabetes 58: 1852-62 (Added 2010-09-01 15:24:56.688519)
19136653 Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. (2009) Diabetes 58: 882-93 (Added 2011-05-19 14:13:43.64028)
18845646 Fiaschi-Taesch N, Sicari B, Ubriani K, Cozar-Castellano I, Takane KK, Stewart AF Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation of p15Ink4b and p27kip1. (2009) Endocrinology 150: 1429-39 (Added 2011-03-08 09:48:23.685195)
18820214 Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets. (2008) Diabetes 57: 2745-54 (Added 2011-05-19 14:13:43.649284)
18650366 Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. (2008) Diabetes 57: 3056-68 (Added 2011-05-19 14:14:36.009022)
18633102 Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF Hepatocyte Growth Factor (HGF) Enhances Engraftment and Function of Non-Human Primate Islets. (2008) Diabetes : (Added 2011-05-19 14:14:36.023154)
17192465 Vasavada RC, Cozar-Castellano I, Sipula D, Stewart AF Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function. (2007) Diabetes 56: 57-64 (Added 2010-09-01 15:24:56.703867)
17130470 Cozar-Castellano I, Haught M, Stewart AF The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo. (2006) Diabetes 55: 3271-8 (Added 2010-08-11 17:22:12.961007)
17023675 Fiaschi-Taesch N, Sicari BM, Ubriani K, Bigatel T, Takane KK, Cozar-Castellano I, Bisello A, Law B, Stewart AF Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: definition of an arterial smooth muscle PTHrP/p27kip1 pathway. (2006) Circ Res 99: 933-42 (Added 2011-03-08 09:48:23.728365)
16638909 Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF Molecular control of cell cycle progression in the pancreatic beta-cell. (2006) Endocr Rev 27: 356-70 (Added 2011-05-19 14:14:36.061522)
16380478 Cozar-Castellano I, Weinstock M, Haught M, Velázquez-Garcia S, Sipula D, Stewart AF Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip. (2006) Diabetes 55: 70-7 (Added 2010-08-11 17:22:55.388046)
15911749 Cozar-Castellano I, Stewart AF Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy. (2005) Proc Natl Acad Sci U S A 102: 7781-2 (Added 2010-08-11 17:22:55.393083)
15210588 Fiaschi-Taesch N, Takane KK, Masters S, Lopez-Talavera JC, Stewart AF Parathyroid-hormone-related protein as a regulator of pRb and the cell cycle in arterial smooth muscle. (2004) Circulation 110: 177-85 (Added 2011-03-08 09:48:56.602369)
14693709 Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. (2004) Diabetes 53: 149-59 (Added 2011-05-19 14:14:36.08258)
14551233 Lopez-Talavera JC, Garcia-Ocaña A, Sipula I, Takane KK, Cozar-Castellano I, Stewart AF Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation. (2004) Endocrinology 145: 467-74 (Added 2011-05-19 14:15:22.856797)
12538599 Fiaschi-Taesch NM, Stewart AF Minireview: parathyroid hormone-related protein as an intracrine factor--trafficking mechanisms and functional consequences. (2003) Endocrinology 144: 407-11 (Added 2011-03-08 09:48:56.619526)
12403787 Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. (2003) J Biol Chem 278: 343-51 (Added 2011-05-19 14:15:22.866271)
12351440 Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. (2002) Diabetes 51: 3003-13 (Added 2011-05-19 14:15:22.874664)
11723058 García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. (2001) Diabetes 50: 2752-62 (Added 2011-05-19 14:15:22.882832)
11517189 de Miguel F, Fiaschi-Taesch N, López-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. (2001) Endocrinology 142: 4096-105 (Added 2011-03-08 09:48:56.646709)
11238473 García-Ocaña A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF Using beta-cell growth factors to enhance human pancreatic Islet transplantation. (2001) J Clin Endocrinol Metab 86: 984-8 (Added 2011-05-19 14:15:22.891198)
10809775 Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. (2000) J Biol Chem 275: 15399-406 (Added 2010-09-01 15:27:02.308247)
10625667 Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. (2000) J Biol Chem 275: 1226-32 (Added 2011-05-19 14:15:47.300948)
9724026 Porter SE, Sorenson RL, Dann P, Garcia-Ocana A, Stewart AF, Vasavada RC Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. (1998) Endocrinology 139: 3743-51 (Added 2010-09-01 15:27:58.31187)
9050887 Reddy D, Pollock AS, Clark SA, Sooy K, Vasavada RC, Stewart AF, Honeyman T, Christakos S Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38). (1997) Proc Natl Acad Sci U S A 94: 1961-6 (Added 2010-09-01 15:27:58.319356)
8798692 Wu TL, Vasavada RC, Yang K, Massfelder T, Ganz M, Abbas SK, Care AD, Stewart AF Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. (1996) J Biol Chem 271: 24371-81 (Added 2010-09-01 15:27:58.322895)
8557651 Vasavada RC, Cavaliere C, D'Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick W, Stewart AF Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. (1996) J Biol Chem 271: 1200-8 (Added 2010-09-01 15:27:58.330304)
8382601 Gaich G, Orloff JJ, Atillasoy EJ, Burtis WJ, Ganz MB, Stewart AF Amino-terminal parathyroid hormone-related protein: specific binding and cytosolic calcium responses in rat insulinoma cells. (1993) Endocrinology 132: 1402-9 (Added 2010-08-11 17:34:32.816475)
7775469 Plawner LL, Philbrick WM, Burtis WJ, Broadus AE, Stewart AF Cell type-specific secretion of parathyroid hormone-related protein via the regulated versus the constitutive secretory pathway. (1995) J Biol Chem 270: 14078-84 (Added 2010-08-11 17:34:01.616523)
Resource ID Name Contributed on Primary Contributor
4007 OE.Human.CDK6.CMV Jul 30, 2010 Yes
4008 OE.Human.CDK4.CMV Jul 30, 2010 Yes
4009 OE.Human.CCND1.CMV Jul 30, 2010 Yes
4010 OE.Human.CCND2.CMV Jul 30, 2010 Yes
4011 OE.Human.CCND3.CMV Jul 30, 2010 Yes
4100 OE.Human.CDK6.Tetracycline Responsive Element (TRE) May 12, 2011 Yes
4101 OE.E. coli.rtTA.CMV May 12, 2011 Yes
4124 Assessment of vascularization of islet grafts Aug 15, 2011
4263 Human and Rodent Ocular Transplantation Mar 2, 2012 Yes
4588 RIP1-ZsGreen plasmid May 13, 2013 Yes
10 completed resources viewable