Louis Philipson, M.D. - Investigator Profile
Louis Philipson, MD, PhD, is a Professor in the Department of Medicine and Pediatrics at the University of Chicago and Director of the Kovler Diabetes Center. He is an Endocrinologist specializing in diabetes, and a scientist studying biophysical, molecular, and genetic aspects of insulin secretion, and the genetics of diabetes. His research has focused on ion channel regulation of insulin secretion, use of biosensors to report cellular activity, and detection of reactive oxygen species in insulin secreting cells. His major translational research activity is in monogenic diabetes, both neonatal diabetes and genes associated with MODY, with his colleague Dr Graeme Bell. Employing the tools of molecular biology, electrophysiology and live cell fluorescence confocal imaging, he studies the role of ion channels in insulin secretion. He has published a series of studies on the role of repolarizing potassium channels in the beta cell, highlighted by a 2007 paper in Cell Metabolism on action potentials, calcium flux and insulin secretion in the Kv2.1 null mouse, a mouse model lacking a delayed rectifier potassium channel. He recently was a co-discoverer of insulin gene mutations causing neonatal diabetes, a novel class of mutations causing diabetes through beta cell ER stress. These mutations are now known to be the second most common cause of permanent neonatal diabetes as well as rare causes of later onset diabetes. He is a resource for neonatal diabetes in the United States, with over 20 patients diagnosed with KCNJ11 mutations and transferred to oral agents from insulin in the last two years. He has also recently established the first United States registry for neonatal diabetes with colleague Dr. G. Bell.
|19952343||Rajan S, Eames SC, Park SY, Labno C, Bell GI, Prince V, Philipson LH In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. (2010) Am J Physiol Endocrinol Metab : (Added 2010-01-14 18:43:15.10198)|
|19808024||Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ The granular chloride channel ClC-3 is permissive for insulin secretion. (2009) Cell Metab 10: 316-23 (Added 2010-01-14 18:43:15.107131)|
|19383458||Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. (2009) Biophys J 96: 3126-39 (Added 2010-01-14 18:43:15.11003)|
|18662362||Støy J, Greeley SA, Paz VP, Ye H, Pastore AN, Skowron KB, Lipton RB, Cogen FR, Bell GI, Philipson LH, United States Neonatal Diabetes Working Group Diagnosis and treatment of neonatal diabetes: a United States experience. (2008) Pediatr Diabetes 9: 450-9 (Added 2010-01-14 18:44:06.579956)|
|18452988||Tamarina NA, Kuznetsov A, Philipson LH Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells. (2008) Cell Calcium 44: 533-44 (Added 2010-01-14 18:44:06.584528)|
|17767909||Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. (2007) Cell Metab 6: 229-35 (Added 2010-01-14 18:44:19.464142)|