Yi Zhang, Ph.D.

Fred Rosen Professor, Dept. Genetics & Dept. of Pediatrics; HHMI Investigator
Harvard Medical School & Boston Children''s Hospital
Program in Cellular & Molecular Medicine

WAB-149G, 200 Longwood Av.
Boston, MA 02115
USA

p. (617)-713-8666
f. (617)-713-8665
· email
· website

Yi Zhang, Ph.D. - Investigator Profile

Epigenetic modifications, particularly DNA methylation and covalent histone modifications, play an important role in regulating chromatin dynamics and therefore have a significant impact on gene expression. Our lab is interested in how epigenetic-mediated dynamic changes in chromatin structure affect gene expression, cell lineage commitment, endoderm and beta cell development and diabetes. Our long-term goal is to apply this basic research to studies of human diseases.

Scientific Interests/Keywords

Epigenetics, reprogramming, stem cells, iPS cells, chromatin, transcription, islet transplantation, transdifferentiation

Professor, Biochemistry and Biophysics; HHMI Investigator, Zhang Lab

Publications
Contributions

Publication	Citation
23247625	Liang G, Zhang Y Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. (2013) Cell Res 23: 49-69 (Added 2013-03-14 07:54:43.616313)
23184059	Inoue A, Matoba S, Zhang Y Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidation. (2012) Cell Res 22: 1640-9 (Added 2013-03-14 07:57:03.739398)
23151479	Yamaguchi S, Hong K, Liu R, Shen L, Inoue A, Diep D, Zhang K, Zhang Y Tet1 controls meiosis by regulating meiotic gene expression. (2012) Nature 492: 443-7 (Added 2013-03-14 07:56:31.868617)
22910204	Shen L, Zhang Y Enzymatic analysis of tet proteins: key enzymes in the metabolism of DNA methylation. (2012) Methods Enzymol 512: 93-105 (Added 2012-08-29 22:45:03.989232)
22907667	Jiang W, Wang J, Zhang Y Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. (2013) Cell Res 23: 122-30 (Added 2013-03-14 08:09:48.58209)
22772155	Nabel CS, Jia H, Ye Y, Shen L, Goldschmidt HL, Stivers JT, Zhang Y, Kohli RM AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation. (2012) Nat Chem Biol 8: 751-8 (Added 2013-03-14 07:57:32.488843)
22560071	Wu H, Zhang Y Early embryos reprogram DNA methylation in two steps. (2012) Cell Stem Cell 10: 487-9 (Added 2013-03-14 07:57:59.535558)
22522173	Liang G, He J, Zhang Y Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. (2012) Nat Cell Biol 14: 457-66 (Added 2013-03-14 07:58:26.207344)
22156206	Wu H, Zhang Y Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011) Genes Dev 25: 2436-52 (Added 2013-03-14 07:59:22.372198)
22124233	Inoue A, Shen L, Dai Q, He C, Zhang Y Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. (2011) Cell Res 21: 1670-6 (Added 2013-03-14 07:58:57.053338)
21940858	Inoue A, Zhang Y Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. (2011) Science 334: 194 (Added 2013-03-14 08:04:22.743029)
21778364	Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. (2011) Science 333: 1300-3 (Added 2013-03-14 08:06:01.067279)
21769133	Nguyen AT, He J, Taranova O, Zhang Y Essential role of DOT1L in maintaining normal adult hematopoiesis. (2011) Cell Res 21: 1370-3 (Added 2013-03-14 08:05:02.910444)
21724828	Nguyen AT, Zhang Y The diverse functions of Dot1 and H3K79 methylation. (2011) Genes Dev 25: 1345-58 (Added 2013-03-14 08:06:31.029169)
21659531	Wu SC, Zhang Y Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability. (2011) J Biol Chem 286: 28511-9 (Added 2013-03-14 08:05:33.102925)
21521783	Nguyen AT, Taranova O, He J, Zhang Y DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. (2011) Blood 117: 6912-22 (Added 2013-03-14 08:06:51.357677)
21460036	Wu H, D'Alessio AC, Ito S, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. (2011) Genes Dev 25: 679-84 (Added 2013-03-14 08:07:17.974996)
21451524	Wu H, D'Alessio AC, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. (2011) Nature 473: 389-93 (Added 2013-03-14 08:07:39.958267)
21310926	He J, Nguyen AT, Zhang Y KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. (2011) Blood 117: 3869-80 (Added 2013-03-14 08:08:05.053747)
21289070	Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y DOT1L regulates dystrophin expression and is critical for cardiac function. (2011) Genes Dev 25: 263-74 (Added 2013-03-14 08:08:27.38449)
21251613	Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. (2011) Cancer Cell 19: 17-30 (Added 2013-03-14 08:08:56.932929)
20683471	Wu SC, Zhang Y Active DNA demethylation: many roads lead to Rome. (2010) Nat Rev Mol Cell Biol : (Added 2010-08-23 14:47:31.60749)

Resource ID	Name	Contributed on	Primary Contributor
1641	Generate insulin-secreting islet clusters from human iPS	Jun 26, 2009	Yes
4578	Generation of PDX1-positive cells with potent TGF-beta inhibitors	Mar 13, 2013	Yes
4579	Transcriptome analysis of beta cell lineage using human ESC derivate and islet subtypes	Mar 13, 2013	Yes
4584	Transcriptome profiling of human pancreatic cell lineage specification reveals functional signaling pathways and lncRNAs for cell fate determination	Apr 16, 2013	Yes
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