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Anil Bhushan, Ph.D.

Associate Professor
University of California, Los Angeles
Medicine

900A Weybern place, UCLA
Los Angeles, CA 90024
USA

p. 310-206-5750
f. 310-206-5368
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Anil Bhushan, Ph.D. - Investigator Profile

Diabetes results from an inadequate mass of functional beta cells. Such inadequacy could result from loss of beta cells due to an immune assault or the lack of compensation to overcome insulin resistance. Developing ways to replenish this deficit in beta cells will be key for developing therapies. This could involve either generating beta cells in vitro from stem cells for use in cell-based therapies or to foster the regeneration and expansion of endogenous beta cells. Our laboratory focuses on understand the molecular mechanisms that govern beta cell formation during embryogenesis as well as the expansion/regeneration of beta cell mass in adult and diabetes animal models. We specifically focus on how complex patterning information controlling fundamental cellular processes such as differentiation and proliferation of progenitor cell is integrated during the process of pancreatic organogenesis. Another interest of the laboratory is to understand how beta cell growth is regulated to compensate for the changing insulin demand. Strategies for tackling these complex problems include the generation and analysis of null mouse mutants, development of cell-type-specific inducible transgenic mice, and in vitro human islet cultures to study metabolic characteristics.

Scientific Interests/Keywords

beta cell regeneration, cell cycle regulation, embryogenesis

Associate Professor, Bhushan Lab

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Publication Citation
22056672 Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. (2011) Genes Dev 25: 2291-305 (Added 2014-03-12 21:07:15.063524)
21980072 Tschen SI, Georgia S, Dhawan S, Bhushan A Skp2 is required for incretin hormone-mediated β-cell proliferation. (2011) Mol Endocrinol 25: 2134-43 (Added 2014-03-12 21:07:19.493592)
21497756 Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. (2011) Dev Cell 20: 419-29 (Added 2012-03-13 16:49:33.308493)
19390085 Dhawan S, Tschen SI, Bhushan A Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. (2009) Genes Dev 23: 906-11 (Added 2009-07-28 00:00:00)
19228811 Tschen SI, Dhawan S, Gurlo T, Bhushan A Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. (2009) Diabetes 58: 1312-20 (Added 2009-06-23 18:19:15)
18334605 Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. (2008) Diabetes 57: 1584-94 (Added 2009-12-15 14:19:15.120424)
18061427 Dhawan S, Georgia S, Bhushan A Formation and regeneration of the endocrine pancreas. (2007) Curr Opin Cell Biol 19: 634-45 (Added 2009-12-15 14:19:32.40914)
17823659 Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. (2007) J Clin Invest 117: 2869-76 (Added 2012-03-13 16:49:46.79745)
Resource ID Name Contributed on Primary Contributor
4116 Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx Aug 2, 2011 Yes
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