Jake Kushner, M.D.
McNair Scholar, Section Head
Baylor College of Medicine
Pediatric Diabetes and Endocrinology
One Baylor Plaza
Houston, TX 77030
Jake Kushner, M.D. - Account Profile
My career goal is to improve the health of children and adults with diabetes, contributing to the development of cell based insulin replacement therapies. As a pediatric endocrinologist, I am acutely aware of the great need for regeneration of beta-cell mass for patients with type 1 or type 2 diabetes. However, this challenge is not trivial, as a great deal remains to be learned about the basic biology of islet growth. Ultimately we hope to elucidate the major mechanisms that control beta-cell proliferation at the cell cycle level, anticipating that some upstream beta-cell signals might be amenable to pharmacological intervention.
Beta cell regeneration, beta-cell survival.
|21178965||Tuttle AH, Rankin MM, Teta M, Sartori DJ, Stein GM, Kim GJ, Virgilio C, Granger A, Zhou D, Long SH, Schiffman AB, Kushner JA Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. (2010) J Vis Exp : (Added 2011-03-01 11:51:20.96892)|
|21099336||Rankin MM, Kushner JA Aging induces a distinct gene expression program in mouse islets. (2010) Islets 2: 4-11 (Added 2011-03-01 11:51:20.982235)|
|19628581||He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, Long SY, Diehl JA, Kushner JA Cyclin D2 protein stability is regulated in pancreatic beta-cells. (2009) Mol Endocrinol 23: 1865-75 (Added 2011-03-01 11:51:20.992897)|
|19265026||Rankin MM, Kushner JA Adaptive beta-cell proliferation is severely restricted with advanced age. (2009) Diabetes 58: 1365-72 (Added 2011-03-01 11:51:21.021413)|
|17488631||Teta M, Rankin MM, Long SY, Stein GM, Kushner JA Growth and regeneration of adult beta cells does not involve specialized progenitors. (2007) Dev Cell 12: 817-26 (Added 2011-03-01 11:51:21.031377)|