Juli (Hsiao-Huei) Wu, Ph.D.

Assistant Professor of Research
University of Southern California
Cell and Neurobiology

Zilkha Neurogeneitic Institute, University of Southern California, 1501 San Pablo St. ZNI 237
Los Angeles, CA 90089-2821
USA

p. 323-442-2996
· email

Juli (Hsiao-Huei) Wu, Ph.D. - Account Profile

Scientific Interests/Keywords

Sensory and motor abnormalities are common in patients with various childhood developmental neuropsychological disorders. However the contribution of peripheral sensory and motor abnormalities to the etiologies is not well understood. In the past 10 years great effort has poured into genetic studies in these childhood disorders and a vest amount of genes associated with these disorders has been identified. My approach is to take advantage of this great wealth of genes and examine their potential roles in peripheral sensory and motor development. This will lead to better understanding in peripheral motor and sensory development as well as the etiology of the sensory/motor abnormality in patients. My current focus is on MET receptor tyrosine kinase and its signaling ligand, hepatocyte growth factor (HGF). MET is associated with autism spectrum disorders (ASD) and its association with ASD had been replicated by at least 6 independent studies. Even though the diagnosis of autism is based on the deficits in language and social interaction as well as the presence of repetitive or restrictive behaviors and interests, more than 90% of ASD patients exhibit sensory and motor abnormalities. Earlier studies in animal models suggest a role of MET and HGF signaling in peripheral motor and sensory development, however the exact mechanisms and the consequences of the behavior outcomes are not well characterized. Through a careful examination of the expression of MET and HGF in mouse at different developmental stages I found expression of MET and HGF in several peripheral sensory and motor system in a spatial temporal restricted manner. Using several lines of transgenic mice and primary culture systems I am currently investigating the role of MET and HGF in peripheral sensory and motor development.

Publications

Publication	Citation
23548689	Wu HH, Levitt P Prenatal Expression of MET Receptor Tyrosine Kinase in the Fetal Mouse Dorsal Raphe Nuclei and the Visceral Motor/Sensory Brainstem. (2013) Dev Neurosci : (Added 2013-04-04 15:51:04.895039)
21852401	Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. (2011) Development : (Added 2011-09-07 16:08:30.425846)
19915564	Wu HH, Bellmunt E, Scheib JL, Venegas V, Burkert C, Reichardt LF, Zhou Z, Fariñas I, Carter BD Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. (2009) Nat Neurosci : (Added 2009-11-17 18:59:28.995371)
19297409	Kawauchi S, Kim J, Santos R, Wu HH, Lander AD, Calof AL Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. (2009) Development 136: 1453-64 (Added 2009-04-14 16:08:23)
16991114	Qu S, Rinehart C, Wu HH, Wang SE, Carter B, Xin H, Kotlikoff M, Arteaga CL Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategy. (2006) Genesis 44: 477-86 (Added 2008-10-20 10:53:54)
15976303	Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL GDF11 controls the timing of progenitor cell competence in developing retina. (2005) Science 308: 1927-30 (Added 2008-10-20 10:52:00)
15711058	Kawauchi S, Beites CL, Crocker CE, Wu HH, Bonnin A, Murray R, Calof AL Molecular signals regulating proliferation of stem and progenitor cells in mouse olfactory epithelium. (2004) Dev Neurosci 26: 166-80 (Added 2008-10-20 10:52:20)
12546816	Wu HH, Ivkovic S, Murray RC, Jaramillo S, Lyons KM, Johnson JE, Calof AL Autoregulation of neurogenesis by GDF11. (2003) Neuron 37: 197-207 (Added 2008-10-20 10:52:58)
12203696	Calof AL, Bonnin A, Crocker C, Kawauchi S, Murray RC, Shou J, Wu HH Progenitor cells of the olfactory receptor neuron lineage. (2002) Microsc Res Tech 58: 176-88 (Added 2008-10-20 10:53:22)
11964141	Furuta S, Ortiz F, Zhu Sun X, Wu HH, Mason A, Momand J Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. (2002) Biochem J 365: 639-48 (Added 2008-10-20 10:54:28)
10998350	Wu HH, Thomas JA, Momand J p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes. (2000) Biochem J 351: 87-93 (Added 2008-10-20 10:54:45)
10721693	Momand J, Wu HH, Dasgupta G MDM2--master regulator of the p53 tumor suppressor protein. (2000) Gene 242: 15-29 (Added 2008-10-20 10:55:06)
10360791	Li JR, Chou CK, McDougall JA, Dasgupta G, Wu HH, Ren RL, Lee A, Han J, Momand J TP53 tumor suppressor protein in normal human fibroblasts does not respond to 837 MHz microwave exposure. (1999) Radiat Res 151: 710-6 (Added 2008-10-20 10:55:28)
9668066	Wu HH, Momand J Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation. (1998) J Biol Chem 273: 18898-905 (Added 2008-10-20 10:55:47)
8254778	Sanderson CM, Wu HH, Nayak DP Sendai virus M protein binds independently to either the F or the HN glycoprotein in vivo. (1994) J Virol 68: 69-76 (Added 2008-10-20 10:56:14)