Guoqiang Gu, Ph.D.
Department of Cell and Developmental Biology
4130B MRB III 465 21st Avenue South
Nashville, TN 37232-8240
Guoqiang Gu, Ph.D. - Investigator Profile
We use mouse and chicken embryos as models to study what factors are required for endocrine islet differentiation and cellular/functional maintenance. We identify factors that are sufficient to induce endocrine differentiation in model organisms and then determine whether they induce islet production from non-beta cells in postnatal mice. Typical projects in the lab include: 1) determine the expression patterns of candidate genes in pancreatic tissues, determine the effect of expressing these candidate genes in chicken embryos; 2) characterize the pancreatic phenotypes in mouse mutants; 3) create gene knockout and knockin constructs; and 4) using combinatorial cell lineage marking to examine/identify the competence factors that direct selection of particular islet cell types from endocrine progenitors; and 5) examining the molecules/growth factors that facilitate endocrine cell production from none-endocrine islet cells in regenerattion models.
Endocirne islet cell differentiation and functional maintenance, adult pancreatic progenitor during regeneration, cell marking and cell lineage