Ahmed Mansouri, PhD - Account Profile
The laboratory is interested in identifying factors that are required for midbrain dopaminergic neuron differentiation. One of the goals of the work is to generate embryonic stem cell-derived dopaminergic neurons with mesencephalic characteristics. In addition, the research group is interested in the molecular mechanisms controlling pancreatic endocrine cell subtype specification. We are using mouse genetics and embryonic stem cell-based technologies.
Scientific Interests/Keywords
mouse ES cells, endocrine pancreas, Parkinson disease, Midbrain development, in vitro differentiation of ES cells
Publications
| PubMedID | Citation |
|---|---|
| 19665969 | Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A. The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into alpha and Subsequently beta Cells. () Cell 138: 449-62 |
| 19340810 | Mansouri A, Fukumitsu H, Schindehuette J, Krieglstein K. Differentiation of embryonic stem cells. () Curr Protoc Neurosci Chapter 3: Unit3.6 |
| 19091768 | Zhou J, Du YR, Qin WH, Hu YG, Huang YN, Bao L, Han D, Mansouri A, Xu GL. RIM-BP3 is a manchette-associated protein essential for spermiogenesis. (2008) Development 136: 373-82 |
| 18612432 | Dressel R, Schindehutte J, Kuhlmann T, Elsner L, Novota P, Baier PC, Schillert A, Bickeboller H, Herrmann T, Trenkwalder C, Paulus W, Mansouri A. The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response. (2008) PLoS ONE 3: e2622 |
| 18513381 | Thompson JA, Zembrzycki A, Mansouri A, Ziman M. Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular development. (2008) BMC Dev Biol 8: 62 |
| 17470284 | Zembrzycki A, Griesel G, Stoykova A, Mansouri A. Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. (2007) Neural Develop 2: 8 |
| 17166926 | Pillai A, Mansouri A, Behringer R, Westphal H, Goulding M. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. (2007) Development 134: 357-66 |
| 16724529 | Schindehutte J, Paulus W, Mansouri A. [Stem cell therapy in Parkinson disease] (2006) Pharm Unserer Zeit 35: 250-4 |
| 16461927 | Asbreuk CH, van Doorninck JH, Mansouri A, Smidt MP, Burbach JP. Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1. (2006) J Mol Endocrinol 36: 65-71 |
| 16380438 | Relaix F, Montarras D, Zaffran S, Gayraud-Morel B, Rocancourt D, Tajbakhsh S, Mansouri A, Cumano A, Buckingham M. Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. (2006) J Cell Biol 172: 91-102 |
| 16150900 | Amendola E, De Luca P, Macchia PE, Terracciano D, Rosica A, Chiappetta G, Kimura S, Mansouri A, Affuso A, Arra C, Macchia V, Di Lauro R, De Felice M. A mouse model demonstrates a multigenic origin of congenital hypothyroidism. (2005) Endocrinology 146: 5038-47 |
| 16122727 | Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P. Genetic determinants of pancreatic epsilon-cell development. (2005) Dev Biol 286: 217-24 |
| 15930104 | Collombat P, Hecksher-Sorensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A. The simultaneous loss of Arx and Pax4 genes promotes a (2005) Development 132: 2969-80 |
| 15910765 | Thinyane K, Baier PC, Schindehutte J, Mansouri A, Paulus W, Trenkwalder C, Flugge G, Fuchs E. Fate of pre-differentiated mouse embryonic stem cells transplanted in (2005) Brain Res 1045: 80-7 |
| 15843801 | Relaix F, Rocancourt D, Mansouri A, Buckingham M. A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. (2005) Nature 435: 948-53 |
| 15625119 | Schindehutte J, Fukumitsu H, Collombat P, Griesel G, Brink C, Baier PC, Capecchi MR, Mansouri A. In vivo and in vitro tissue-specific expression of green fluorescent (2005) Stem Cells 23: 10-5 |
| 15581879 | Parlato R, Rosica A, Rodriguez-Mallon A, Affuso A, Postiglione MP, Arra C, Mansouri A, Kimura S, Di Lauro R, De Felice M. An integrated regulatory network controlling survival and migration in (2004) Dev Biol 276: 464-75 |
| 15153616 | Baier PC, Schindehutte J, Thinyane K, Flugge G, Fuchs E, Mansouri A, Paulus W, Gruss P, Trenkwalder C. Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after (2004) Stem Cells 22: 396-404 |
| 15132998 | Relaix F, Rocancourt D, Mansouri A, Buckingham M. Divergent functions of murine Pax3 and Pax7 in limb muscle development. (2004) Genes Dev 18: 1088-105 |
| 15116098 | EL Naaman C, Grum-Schwensen B, Mansouri A, Grigorian M, Santoni-Rugiu E, Hansen T, Kriajevska M, Schafer BW, Heizmann CW, Lukanidin E, Ambartsumian N. Cancer predisposition in mice deficient for the metastasis-associated (2004) Oncogene 23: 3670-80 |
| 14597661 | Treichel D, Schock F, Jackle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development. (2003) Genes Dev 17: 2630-5 |
| 14561778 | Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P. Opposing actions of Arx and Pax4 in endocrine pancreas development. (2003) Genes Dev 17: 2591-603 |
| 12586753 | Friedrichsen S, Christ S, Heuer H, Schafer MK, Mansouri A, Bauer K, Visser TJ. Regulation of iodothyronine deiodinases in the Pax8-/mouse model of (2003) Endocrinology 144: 777-84 |
| 11773436 | Flamant F, Poguet AL, Plateroti M, Chassande O, Gauthier K, Streichenberger N, Mansouri A, Samarut J. Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by (2002) Mol Endocrinol 16: 24-32 |
