Alvin Powers, M.D.
Professor of Medicine
Vanderbilt University
Diabetes Center
802 Light Hall 2215 Garland Avenue
Nashville,
TN
37232-0615
USA
p. 615-936-7678
f. 615-936-0063
· email
Alvin Powers, M.D. - Investigator Profile
Our laboratory is conducting research in three areas. First, we are studying the sequence of molecular events and factors important for the development of normal islet vasculature and innervation and the revascularization of transplanted human and murine pancreatic islets. Second, we are investigating the molecular mechanisms of islet growth and regeneration with a focus on growth factors and signal transduction pathways in both rodent and human pancreatic islets. Third, we are developing in vivo bioluminescence and other technologies to image and quantify pancreatic islets in the pancreas and after transplantation.
Scientific Interests/Keywords
diabetes, islet function, islet transplantation, vascularization
Affiliates
Publications
| PubMedID | Citation |
|---|---|
| 19548035 | Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers AC. Bioluminescence Imaging in Mouse Models Quantifies beta Cell Mass in the Pancreas and After Islet Transplantation. (2009) Mol Imaging Biol : |
| 18846254 | Nyman LR, Wells KS, Head WS, McCaughey M, Ford E, Brissova M, Piston DW, Powers AC. Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. (2008) J Clin Invest 118: 3790-7 |
| 18753672 | Brissova M, Powers AC. Revascularization of transplanted islets: can it be improved? () Diabetes 57: 2269-71 |
| 18398139 | Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers AC, Wasserman DH. Glucose metabolism in vivo in four commonly used inbred mouse strains. (2008) Diabetes 57: 1790-9 |
| 17065333 | Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. () Diabetes 55: 2974-85 |
Resource Contributions
| Resource ID | Name | Contributed on |
|---|---|---|
| 237 | FVB/NJ-Tg(MIP-Luc-VU)3Pwrs/J | May 16, 2008 |
| 1 completed resources viewable | ||
