Yi Zhang, Ph.D.
Professor, Biochemistry and Biophysics; HHMI Investigator
The University of North Carolina at Chapel Hill/Howard Hughes Medical Institute
Lineberger Comprehensive Cancer Center
LCCC 450 West Drive, CB#7295
Chapel Hill,
NC
27599-7295
USA
Yi Zhang, Ph.D. - Investigator Profile
Epigenetic modifications, particularly DNA methylation and covalent histone modifications, play an important role in regulating chromatin dynamics and therefore have a significant impact on gene expression. Our lab is interested in how epigenetic-mediated dynamic changes in chromatin structure affect gene expression, cell lineage commitment, endoderm and beta cell development and diabetes. Our long-term goal is to apply this basic research to studies of human diseases.
Scientific Interests/Keywords
Epigenetics, reprogramming, stem cells, iPS cells, chromatin, transcription, islet transplantation, transdifferentiation
Affiliates
Publications
| PubMedID | Citation |
|---|---|
| 20683471 | Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. (2010) Nat Rev Mol Cell Biol : |
| 20680032 | Wu SC, Kallin EM, Zhang Y. Role of H3K27 methylation in the regulation of lncRNA expression. (2010) Cell Res : |
| 20639862 | Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (2010) Nature : |
| 20554530 | Liang G, Taranova O, Xia K, Zhang Y. Butyrate promotes induced pluripotent stem cell generation. (2010) J Biol Chem 285: 25516-21 |
| 20051435 | He J, Zhang Y. Janus Kinase 2: An Epigenetic 'Writer' that Activates Leukemogenic Genes. (2010) J Mol Cell Biol : |
| 19194461 | Tateishi K, Okada Y, Kallin EM, Zhang Y. null (2009) Nature null: null |
| 19114561 | Lee N, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. The H3K4 Demethylase Lid Associates with and Inhibits Histone Deacetylase Rpd3. (2009) Mol Cell Biol 29: 1401-10 |
| 18836456 | He J, Kallin EM, Tsukada Y, Zhang Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). (2008) Nat Struct Mol Biol 15: 1169-75 |
| 18787701 | Jones B, Su H, Bhat A, Lei H, Bajko J, Hevi S, Baltus GA, Kadam S, Zhai H, Valdez R, Gonzalo S, Zhang Y, Li E, Chen T. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. (2008) PLoS Genet 4: e1000190 |
| 18782754 | Tateishi K, He J, Taranova O, Liang G, D'Alessio AC, Zhang Y. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. (2008) J Biol Chem 283: 31601-7 |
| 18488009 | Lee N, Zhang Y. Chemical answers to epigenetic crosstalk. (2008) Nat Chem Biol 4: 335-7 |
| 18353770 | Lu X, Kovalev GI, Chang H, Kallin E, Knudsen G, Xia L, Mishra N, Ruiz P, Li E, Su L, Zhang Y. Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. (2008) J Biol Chem 283: 13825-33 |
| 18086877 | Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y. Role of hPHF1 in H3K27 methylation and Hox gene silencing. (2008) Mol Cell Biol 28: 1862-72 |
| 18028865 | Graves TL, Zhang Y, Scott JE. A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases. (2008) Anal Biochem 373: 296-306 |
| 17984969 | Klose RJ, Zhang Y. Histone H3 Arg2 methylation provides alternative directions for COMPASS. (2007) Nat Struct Mol Biol 14: 1058-60 |
| 17943087 | Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. (2007) Nature 450: 119-23 |
| 17470555 | Fang J, Hogan GJ, Liang G, Lieb JD, Zhang Y. The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2. (2007) Mol Cell Biol 27: 5055-65 |
| 17466502 | Martin C, Zhang Y. Mechanisms of epigenetic inheritance. (2007) Curr Opin Cell Biol 19: 266-72 |
| 17371840 | Klose RJ, Gardner KE, Liang G, Erdjument-Bromage H, Tempst P, Zhang Y. Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? (2007) Mol Cell Biol 27: 3951-61 |
| 17363312 | Yamane K, Tateishi K, Klose RJ, Fang J, Fabrizio LA, Erdjument-Bromage H, Taylor-Papadimitriou J, Tempst P, Zhang Y. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. (2007) Mol Cell 25: 801-12 |
| 17351631 | Lee N, Zhang J, Klose RJ, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. (2007) Nat Struct Mol Biol 14: 341-3 |
| 17342184 | Klose RJ, Zhang Y. Regulation of histone methylation by demethylimination and demethylation. (2007) Nat Rev Mol Cell Biol 8: 307-18 |
| 17320163 | Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. (2007) Cell 128: 889-900 |
| 17310254 | Liang G, Klose RJ, Gardner KE, Zhang Y. Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. (2007) Nat Struct Mol Biol 14: 243-5 |
| 17210787 | Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. (2007) Genes Dev 21: 49-54 |
| 17101443 | Tsukada Y, Zhang Y. Purification of histone demethylases from HeLa cells. (2006) Methods 40: 318-26 |
| 16983801 | Klose RJ, Kallin EM, Zhang Y. JmjC-domain-containing proteins and histone demethylation. (2006) Nat Rev Genet 7: 715-27 |
| 16968818 | Bender LB, Suh J, Carroll CR, Fong Y, Fingerman IM, Briggs SD, Cao R, Zhang Y, Reinke V, Strome S. MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. (2006) Development 133: 3907-17 |
| 16956976 | Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). (2006) Proc Natl Acad Sci U S A 103: 13956-61 |
| 16921363 | Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. (2006) Nat Cell Biol 8: 1017-24 |
| 16826231 | Zhang Y. It takes a PHD to interpret histone methylation. (2006) Nat Struct Mol Biol 13: 572-4 |
| 16732292 | Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. (2006) Nature 442: 312-6 |
| 16714294 | Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM. Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (2006) J Biol Chem 281: 20643-9 |
| 16678110 | Wang H, Zhai L, Xu J, Joo HY, Jackson S, Erdjument-Bromage H, Tempst P, Xiong Y, Zhang Y. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (2006) Mol Cell 22: 383-94 |
| 16603237 | Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006) Cell 125: 483-95 |
| 16601153 | Huang Y, Fang J, Bedford MT, Zhang Y, Xu RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. (2006) Science 312: 748-51 |
| 16431907 | Martin C, Cao R, Zhang Y. Substrate preferences of the EZH2 histone methyltransferase complex. (2006) J Biol Chem 281: 8365-70 |
| 16415856 | Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. (2006) Nat Cell Biol 8: 188-94 |
| 16415788 | Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, Zhang Y, Bedford MT. Tudor, MBT and chromo domains gauge the degree of lysine methylation. (2006) EMBO Rep 7: 397-403 |
